DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and ece1

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	725	Identity:	168/725 - (23%)
Similarity:	283/725 - (39%)	Gaps:	147/725 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPFTE-------IIQMLDHKVNGNLV 80
            ::|...:.:.:|..:......|..::.:|||.:.   |.:|..|       ...:.:|    |:.
Zfish    83 SEPCVSVASAVLGSLDRSVDPCQDFYNFACGGWM---RKNPLPEGKSRWGPFSNLWEH----NMA 140

  Fly    81 QLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHYLRLAPPGQALT-----WPQFM 140
            .:.:.|...|..   :.|..|.|...:|:.|.    :..|:|..  .|.|.|.|.     |..
Zfish   141 VMKNLLENTSMK---SLSRAEQKAQWYYQACM----NESKIEEL--GAKPLQDLINQTGGWGL-- 194

  Fly   141 PRGEPWPKAQF-KWMKSLGHLYRYGFTNVLVNVLVLRSSE--NSNRFRLD---ISMPSLE----- 194
             :| ||.|..| :.::.:...:|   |:....|.|...|:  |||..::|   :.:||.|
Zfish   195 -KG-PWEKDNFQEVLRIVSANFR---TSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREYYLNK 254

  Fly   195 -GDAQHLGGFLSTLATLQI-IGVPTKSILPLVRKIRRLESAIRVLT--EVDDDDESET-WTLRQW 254
             .:.::|..:|:.|..|.: :|....:...::.:|...|:.:..:|  :|:..||.:. :.::..
Zfish   255 TANEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAK 319

  Fly   255 EYKT---GYAWQGFVESI---VGHSVSHHYVMQAQNAKYFTGLKRLMDSTDAEVVANY----IMT 309
            |..|   ...|..|:.|:   |..:.|...|:.|:  :|...:..|:.:|:..|:.||    ::.
Zfish   320 ELATLAPAIDWMPFLSSVFAPVELNNSEPVVVYAK--EYLQKVSELISNTNKSVLNNYMIMKVVR 382

  Fly   310 RFVLYLIDDFIDSNEHI----------------DCVTDMRRNMNLASNLLY-KERFLD--PATLQ 355
            :.|..|...|.|:.:..                .||:|....:..|...|: |..|.:  .|.::
Zfish   383 KMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWKLCVSDTDSALGFALGALFVKATFSEDSKAFVE 447

  Fly   356 QYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYE 420
            ....|:...||.         :...:.....:....|.:....:.|:...|:      |:....|
Zfish   448 DMVSEIKWAFED---------SLKTVSWMDPETKKAAKEKADAIYNMVGYPK------FIMNPKE 497

  Fly   421 -DLVFPLPDFD-----YAREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMR 479
             |.||  .|||     |.:..:|...|..|....|| :.||..|::     ..|..:...||...
Zfish   498 LDKVF--NDFDVVSDLYFQNVMNYYNFSARVTADQL-RKAPNRDQW-----SMTPPTVNAYYNPT 554

  Fly   480 LNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSP 544
            .|.:|:|.|:.|.||:.........:..:|.|:.|||.|:.|..|..||:.||:.:.. |.||..
Zfish   555 KNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWW-QNSSVE 618

  Fly   545 RFVAGLQCLNRNSTQY------------LDERIADIAGLDLAYSTYF----QNSSQMSLTDFTTI 593
            .|....||:....:.|            |.|.|||..||:.||..|.    :|..:.||... .:
Zfish   619 AFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKAYVNWIKKNGEEASLPAL-GM 682

  Fly   594 PPQQIFFLNLAQFFCG--------DG---DPINFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS- 646
            ...|:||:..||.:|.        :|   ||     |.....|:...::....|.|.|||.|.|
Zfish   683 NNHQLFFVGFAQVWCSVRTPESSHEGVITDP-----HSPSRFRVIGTISNSHEFSEHFGCKADSP 742

  Fly   647 -NQPEKCQLW 655
             |...||:||
Zfish   743 MNPKRKCELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	163/702 (23%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	165/712 (23%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	163/703 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010