Protein Alignment Nepl6 and mmel1

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 783
• Identity: 173/783 - (22%)
• Similarity: 275/783 - (35%)
• Gaps: 230/783 - (29%)

  Fly    12 ICAAPTTQNVEADPNSRLMNNILSYVAEDSSA--CGTYFQYACGKYAVRH--------------- 59
            :|..|......|    ||:.|:      |.|.  |..::|||||.:..||
Zfish    74 VCTTPQCVTAAA----RLLQNM------DPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNIL 128

  Fly    60 RDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTC--------REAPP 116
            ||:  .||:      :.|.|     |:..:.....|.    :||.|  |.:|        |::.|
Zfish   129 RDE--LEIV------LKGVL-----EMENKDDREAFK----KAKTL--YSSCMNEILIEQRDSQP 174

  Fly   117 STRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQFKWMKSLGHLY-----------RYGFTNVLV 170
            ..|.::..                  |: ||.|...|..:....:           ||....||
Zfish   175 LLRLIDSI------------------GD-WPVASEVWNGTSEQTWSLEDTLAVLNGRYNKKAVL- 219

  Fly   171 NVLVLRSSENSNRFRLDISMPSLEGDAQHLGGFLSTLATLQIIGVPTK----------------- 218
            .:.|.....:|:|:.:.:..|:|                    |:|::
Zfish   220 EMFVWPDDRDSSRYIIHVDQPAL--------------------GMPSRDYYLSDGNYKKVREAYL 264

  Fly   219 ----SILPLVRKIRRL-ESAIRVLTEVDDDDESET---------------------WTLRQWEYK 257
                |:..:.|:.|.| :...|||.::....|.||                     .|||:.:..
Zfish   265 EFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYNKMTLREAQQT 329

  Fly   258 ---TGYAWQGFVESI---VGHSVSHHYVMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLI 316
               .|:.|..:::.|   |..||.....:....:.|...|..::.......:.||::...::..:
Zfish   330 FNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQNYLVWMLIMDRV 394

  Fly   317 DD----FIDSNEHI---------------DCVTDMRRNMNLASNLLY-KERFLDPATLQQYTQEV 361
            ..    |.|...|.               |||..::.||..|...|| :|.|...:     .:.|
Zfish   395 SSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFSGNS-----KRMV 454

  Fly   362 TKVFEQLRRQFLLQINENRLGLTSEQNSMVA-TKAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFP 425
            .::.::::..::..:.|  |....||:.:.| .||..:...|| .|   ||  .:....:.|
Zfish   455 GELIKKIQEAYVETLEE--LSWMDEQSKVKAREKAMAISEQIG-YP---DH--ILEEENKKL--- 508

  Fly   426 LPDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKT-------AMSSGPYYLMRLNII 483
              |.:||  |||..|....:.:|: |.:|........|.:|..       |.....:|....|.|
Zfish   509 --DQEYA--HLNFSEENYFENILE-NLAASAQKGHKKLREPVDPDMWIIGAAVVNAFYSHNRNQI 568

  Fly   484 VVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVA 548
            |.|.|:||.|||:........:..:|.|:.||:.|..|..|..:|:.||::......|:. ||..
Zfish   569 VFPAGILQPPFFSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAE-RFED 632

  Fly   549 GLQCL---------------NRNSTQYLDERIADIAGLDLAYSTY---FQNSSQMSLTDFTTIPP 595
            ..:|:               |.:....|.|.|||..|:..||..|   .:...:........:..
Zfish   633 QSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVEREGEEPRLPGLDMNH 697

  Fly   596 QQIFFLNLAQFFCGDGDP------INFVGHDNDETRLQQMLNGFAPFHEAFGCP--AKSNQPEKC 652
            :|:||||.||.:||...|      |....|...|.|:...|..|..|.|||.|.  |..|..|||
Zfish   698 KQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEKC 762

  Fly   653 QLW 655
            ::|
Zfish   763 RVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	162/742 (22%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	163/748 (22%)