Protein Alignment Nepl6 and PHEX

DIOPT Version :9

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 161/743 - (21%)
• Similarity: 281/743 - (37%)
• Gaps: 179/743 - (24%)

  Fly    33 ILSYVAEDSSACGTYFQYACGKYAVRH---RDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPG 94
            |||.|......|..:|::||..:...:   .|.|...:...|.|.|:..|.:|:.:...|.:.
Human    66 ILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRD-- 128

  Fly    95 FNESSVEAKVLHFYRTC--------REAPPSTRKMEHYLRLAPPGQALTWP----QFMPRGEPWP 147
             .|:..:||:|  |.:|        .:|.|    :.|.||.:|    ..||    ...|.| .|.
Human   129 -TEAIQKAKIL--YSSCMNEKAIEKADAKP----LLHILRHSP----FRWPVLESNIGPEG-VWS 181

  Fly   148 KAQFKWMKSLGHLYRYGFTN-VLVNVLVLRSSENSNR--FRLDISMPSLEGDAQHLGGFLSTLA- 208
            :.:|..:::|. .:|..::| |.:.:.|....:.||.  .:||.:..||.....:|..  ||.|
Human   182 ERKFSLLQTLA-TFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDN--STEAK 243

  Fly   209 ------------TLQIIGVPTKSILPLVRKIRRLESAIRVLTEVDDDDESETW-----------T 250
                        |..::|..:......::.:.|||..|..:....::..||..           .
Human   244 SYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAM 308

  Fly   251 LRQWEYKTGYAWQGFVESIVGHSVSHHY--VMQAQNA-----KYFTGLKRLMDSTDAEVVANYIM 308
            :.|::      |.|:::.::...:..|.  :..::|.     :||..|.|::.|...:.:|||::
Human   309 IPQFD------WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLV 367

  Fly   309 TRFVLYLIDD--------FIDSNEHIDCVTDMRRNMNLASNLLYK-------ERFLDPATLQQYT 358
            .|.|...|.:        :::.:..|...|.:....:...|.:..       :.|:|....:...
Human   368 WRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKK 432

  Fly   359 QEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYEDLV 423
            :.:.::.|.:|..|:..:.:....:.:........||:.|:..:|
Human   433 EMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVG-------------------- 477

  Fly   424 FPLPDF----DYAREHLNLLEF----------RTRKQVLQLNQSAPTPDEFFYL--SDPKTAMSS 472
              .|:|    .:..|.|..::|          :|||.:.|        .:||:|  :.|||...:
Human   478 --YPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQ--------SDFFWLRKAVPKTEWFT 532

  Fly   473 GP-----YYLMRLNIIVVPHGLLQEPFFAADSHD-IFKYSLLGFVLAHELMHSVDTVGLYYDRYG 531
            .|     :|....|.|..|.|.||:|||....:. ...|..:|.::.||..|..|..|..||:.|
Human   533 NPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNG 597

  Fly   532 NIHEIGP--QISSSPRFVAGLQC-LNRNSTQY-------------LDERIADIAGLDLAYSTY-- 578
            |   :.|  ...|..:|....:| :|:.|..|             |.|.|||..||..|:..|
Human   598 N---LDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRK 659

  Fly   579 FQNSSQMSLTD-------FTTIPPQQIFFLNLAQFFCGDGDP------INFVGHDNDETRLQQML 630
            :.|..:..|.:       ||.   .|:|||:.|...|....|      :....|...:.|:...:
Human   660 WINDRRQGLEEPLLPGITFTN---NQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAI 721

  Fly   631 NGFAPFHEAFGCPAKSNQ---PEKCQLW 655
            :.|..|.:||.||..|..   .:.|:||
Human   722 SNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	154/730 (21%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	154/731 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910