Protein Alignment Nepl6 and MME

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 169/740 - (22%)
• Similarity: 272/740 - (36%)
• Gaps: 153/740 - (20%)

  Fly    14 AAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPFTEIIQMLDHKVNGN 78
            ||...||::|                .:..|..:|:||||.:..|:       :|.....:. ||
Human    66 AARLIQNMDA----------------TTEPCTDFFKYACGGWLKRN-------VIPETSSRY-GN 106

  Fly    79 LVQLMHELH----QRSQSPGFNESSVEAKVLHFYRTC-REAPPSTRKMEHYLRLAPPGQALTWPQ 138
            ...|..||.    ...|.|...:.....|....||:| .|:...:|..|..|:|.|....
Human   107 FDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYG----- 166

  Fly   139 FMPRGEPWPKAQFKWMKSLGHLY-----------RYGFTNVLVNVLVLRSSENSNRFRLDISMPS 192
                   ||.|...|.:..|..:           :|| ..||:|:.|....:||....:.|..|.
Human   167 -------WPVATENWEQKYGASWTAEKAIAQLNSKYG-KKVLINLFVGTDDKNSVNHVIHIDQPR 223

  Fly   193 L---EGDAQHLGG-----------FLSTLATLQIIGVPTKSILPL--------VRKIRRLESAIR 235
            |   ..|.....|           |:.::|.|    :..:..||:        :.|:..||..|.
Human   224 LGLPSRDYYECTGIYKEACTAYVDFMISVARL----IRQEERLPIDENQLALEMNKVMELEKEIA 284

  Fly   236 VLTEVDDDDES-----ETWTLRQWEYKTG-------YAWQGF---VESIVGHSVSHHYVMQAQNA 285
            ..|...:|...     ...||.|.:....       ::|..|   :.|.|..|:::...:.....
Human   285 NATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAP 349

  Fly   286 KYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDD----FIDSNEHI---------------DCVTD 331
            :|.|.||.::....|..:.|.:..||::.|:..    :.:|....               .|...
Human   350 EYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANY 414

  Fly   332 MRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQ 396
            :..||..|...||    ::.|...:....|..:..|:|..| :|..::...:.:|.......||.
Human   415 VNGNMENAVGRLY----VEAAFAGESKHVVEDLIAQIREVF-IQTLDDLTWMDAETKKRAEEKAL 474

  Fly   397 HVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFF 461
            .:...||.......:.:.::..|.:|.:  .:.:|....:..|:|...||:.:|.:.. ..||:.
Human   475 AIKERIGYPDDIVSNDNKLNNEYLELNY--KEDEYFENIIQNLKFSQSKQLKKLREKV-DKDEWI 536

  Fly   462 YLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLY 526
                 ..|.....:|....|.||.|.|:||.|||:|...:...|..:|.|:.||:.|..|..|..
Human   537 -----SGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRN 596

  Fly   527 YDRYGNIHEIGPQISSSPRFVAGLQCL---------------NRNSTQYLDERIADIAGLD---L 573
            :::.|::.:...|.|:| .|....||:               :.|....|.|.|||..||.   .
Human   597 FNKDGDLVDWWTQQSAS-NFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR 660

  Fly   574 AYSTYFQNSSQMSLTDFTTIPPQQIFFLNLAQFFCGDGDP---INFVG---HDNDETRLQQMLNG 632
            ||..|.:.:.:..|.....:..:|:||||.||.:||...|   :|.:.   |.....|:...|..
Human   661 AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQN 725

  Fly   633 FAPFHEAFGCPAKS--NQPEKCQLW 655
            .|.|.|||.|...|  |..:||::|
Human   726 SAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	161/703 (23%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	162/707 (23%)