DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and Nepl13

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	170/821 - (20%)
Similarity:	307/821 - (37%)	Gaps:	254/821 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WL-----IACLFIVPICAAPTTQNVEAD--------PNSR--------LMNNILSYVAEDSSACG 45
            ||     :..||.:.:|.....:....:        |:||        :..::..|:...:..|.
  Fly     8 WLGFLLELLLLFEIQLCDVTEARQNHMNRMQMSGNFPDSREEQLVRQKIATDVQKYMNLSADPCT 72

  Fly    46 TYFQYACGKYAVRH----RDDPFTEIIQMLDHKVNGNLVQLMHE-LHQRSQSPGFNESSVE--AK 103
            .:|:||||::...|    |.|..:...|:::.|::..|.||:.: |..:....|::.:|:.  .|
  Fly    73 DFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGYSGASMTNVRK 137

  Fly   104 VLHFYRTC--REAPPSTRKMEHYLRLAPPGQALTWPQFMPRGEP---WPKAQFKWMKSLGHLYR- 162
            |..||.:|  .||..|.|: ...:::......|       |..|   |...: :|:::||.|.|
  Fly   138 VRAFYESCVAVEANASERR-RFLMKILKDNGGL-------RNVPNSNWQHNR-QWVQTLGELRRN 193

  Fly   163 YGFTNVLVNVLVLRSSENSNRFRLDISMPSLEGDAQHLGGFLSTLATLQIIGVPTKSILPLVRKI 227
            ||. ::|:.:            .:|:::.:::|:..:.|....|:       :|.:....|..:.
  Fly   194 YGL-DILLGL------------EIDLNLQTMKGNTIYFGEPKLTI-------IPAEHCNALATRG 238

  Fly   228 RRLESAIRVLTEVDDDDESETWTLRQW-EYKTGYAWQGFVESIVGHSVSHHY------------- 278
            .::...:..|.:     :..|..||.| ...||.|     ....|..:...:
  Fly   239 AQVRDEVYELVQ-----QQVTENLRDWFGMDTGEA-----ARFAGDIIRFEFELCKQMGEQDIQK 293

  Fly   279 -------VMQAQ--NAKYFTGLKRL------MDSTD-AEVVANYIMTRFVLYLIDD-------FI 320
                   .:|||  .|:..||.:||      |..|: ...:.|::..:.::.:|.:       ::
  Fly   294 PEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYL 358

  Fly   321 DSNEHI-DCVTDMRRN--MNLASNLLY----------------KERFLDPATLQQYTQEVTKVFE 366
            .|.|:: ..|..::.|  :.:...:||                :.|.....|.:.:.|.:.::|:
  Fly   359 RSPEYVKHVVRTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQ 423

  Fly   367 Q---------------------LRRQFLLQ-INENRLGLTSEQNSMVATKAQHVVLNIGNLPRGR 409
            :                     |..||.:: ::||      ::.:.....:|:.|    :||
  Fly   424 RHVQRDNAKHDLDAVFNDVIKALEEQFHVEWMDEN------DRRAARTRLSQYRV----SLP--- 475

  Fly   410 DHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQL-----NQSAPTPDEFFYLSDPKTA 469
            |::|.   ...||.|...: ||.|.....|::|:.:|...|     .|.|...|.|    :.:.|
  Fly   476 DYQSL---DLTDLQFQKSE-DYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAF----EVRAA 532

  Fly   470 MSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIH 534
            :|.      |..:::|..||||.|::........||:|||..||..|:.:.|      |...|.|
  Fly   533 LSP------RQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFD------DEGWNNH 585

  Fly   535 EIGPQISSSPRFVA------GLQCLN--------------RNSTQYLDERIADIAGLDLAYSTYF 579
               ||.::....|.      ..:|..              ||:|: |.|.|||.:||:||::.|.
  Fly   586 ---PQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNATR-LREIIADGSGLNLAFNAYL 646

  Fly   580 QNSSQ-------------MSLTDFTTIPPQQIFFLNLAQFFCGDGDPINFVGHDNDETRLQQM-- 629
            ....|             :|..:||.   .|:||:..||..|.        ..||.:..|..|
  Fly   647 AWLEQQDHKLRPLLAKETLSELNFTN---TQLFFIYFAQTRCW--------AKDNQDAILDSMPL 700

  Fly   630 -------------LNGFAPFHEAFGCP--AKSNQPEKCQLW 655
                         |:..|.|...|||.  ...|..:||.::
  Fly   701 MQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	160/756 (21%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	159/755 (21%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	159/756 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840