DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and Mmel1

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	768	Identity:	169/768 - (22%)
Similarity:	297/768 - (38%)	Gaps:	201/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPFT----EIIQMLD 72
            ||..|:.....|        .||..:.:....|..::|||||.: :||...|.|    .:..:|.
  Rat    84 ICTTPSCVIAAA--------RILQNMDQSKKPCDNFYQYACGGW-LRHHVIPETNSRYSVFDILR 139

  Fly    73 HKVNGNLVQLMHELHQRSQSPGFNESSVE-------AKVLHFYRTC--------REAPPSTRKME 122
            .::...|..::            .:|||:       ||.|  ||:|        |::.|....::
  Rat   140 DELEVILKGVL------------EDSSVQHRPAVEKAKTL--YRSCMNQSVIEKRDSEPLLNVLD 190

  Fly   123 HYLRLAPPGQALTWPQFMPRGEPWPKAQFKWMKSLGHLY----RYGFTN------VLVNVLVLRS 177
                             |..|  ||.|..||.:::|..:    :....|      ||:::.:...
  Rat   191 -----------------MIGG--WPVAMDKWNETMGPKWELERQLAVLNSQFNRRVLIDLFIWND 236

  Fly   178 SENSNRFRLDISMPSL---------EGDAQHLG----GFLSTLATL--QIIGVP--TKSILPLVR 225
            .:||:|..:.|..|:|         :.|:..:.    .|::::||:  :.:.:|  |..:...:.
  Rat   237 DQNSSRHVIYIDQPTLGMPSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMA 301

  Fly   226 KIRRLESAIRVLTEVDD--------------DDESETWTLRQWEYKTGYAWQGFVESIVGHSVSH 276
            ::..||:.:...|...:              ::..|.:.|:      |:.|..|:::::. ||..
  Rat   302 QVLHLETHLANATVPQEKRHDVTALYHRMGLEELQERFGLK------GFNWTLFIQNVLS-SVQV 359

  Fly   277 HYVMQAQ----NAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDF--------IDSNEHI--- 326
            ..:...:    ...|...|:.::|...|:.:.||::.|.||..|...        :|..:.:
  Rat   360 ELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGT 424

  Fly   327 --------DCVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGL 383
                    :||:.:..||..|...||.:|    |..:.....|:::.|::|..|:..::|  |..
  Rat   425 TMEEVRWRECVSYVNSNMESAVGSLYIKR----AFSKDSKSIVSELIEKIRSVFVDNLDE--LNW 483

  Fly   384 TSEQNSMVATKAQHVVLNIGNLPRGR---------DHRSFVSRHYEDLVFPLPDFDYAREHLNLL 439
            ..|::.   .|||...|||    |.:         |:...:...|..|.|. .|. |....|..|
  Rat   484 MDEESK---KKAQEKALNI----REQIGYPDYILEDNNRHLDEEYSSLTFS-EDL-YFENGLQNL 539

  Fly   440 EFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFK 504
            :...::.:.:|.:..   |:..::..   |.....:|....|:||.|.|:||.|||:.|......
  Rat   540 KNNAQRSLKKLREKV---DQNLWIIG---AAVVNAFYSPNRNLIVFPAGILQPPFFSKDQPQALN 598

  Fly   505 YSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCL---------------N 554
            :..:|.|:.||:.|..|..|..:|:.||:.:.....|:. .|....||:               |
  Rat   599 FGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSAR-HFRQQSQCMIYQYSNFSWELADNQN 662

  Fly   555 RNSTQYLDERIADIAGLDLAYSTYFQNSSQ---------MSLTDFTTIPPQQIFFLNLAQFFCGD 610
            .|....|.|.|||..|:..||..|.|..::         ::||      ..|:||:|.||.:||.
  Rat   663 VNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQRLPGLNLT------YAQLFFINYAQVWCGS 721

  Fly   611 GDP------INFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            ..|      |....|...:.|:...|.....|.|||.||..|  :...:|::|
  Rat   722 YRPEFAIQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	161/734 (22%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	161/734 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910