DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl6 and Mmel1

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	769	Identity:	171/769 - (22%)
Similarity:	290/769 - (37%)	Gaps:	202/769 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPFT----EIIQMLD 72
            ||..|:.....|        .||..:.:..:.|..::|||||.: :||...|.|    .:..:|.
Mouse    75 ICTTPSCVIAAA--------RILENMDQSRNPCENFYQYACGGW-LRHHVIPETNSRYSVFDILR 130

  Fly    73 HKVNGNLVQLMHELHQRSQSPGFNESSVE-AKVLHFYRTC--------REAPP--STRKMEHYLR 126
            .::...|..::.:      |...:..:|| ||.|  ||:|        |::.|  |..||.
Mouse   131 DELEVILKGVLED------STSQHRPAVEKAKTL--YRSCMNQSVIEKRDSEPLLSVLKMV---- 183

  Fly   127 LAPPGQALTWPQFMPRGEPWPKAQFKWMKSLGHLY----RYGFTN------VLVNVLVLRSSENS 181
                             ..||.|..||.:::|..:    :....|      ||:::.:....:||
Mouse   184 -----------------GGWPVAMDKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNS 231

  Fly   182 NRFRLDISMPSL---------EGDAQH-----LGGFLSTLATL----QIIGVPTKSILPLVRKIR 228
            :|..:.|..|:|         :.|..|     ...|::::||:    |.:...:..:...:.::.
Mouse   232 SRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQNLSKESAMVREEMAEVL 296

  Fly   229 RLESAIRVLT--------------EVDDDDESETWTLRQWEYKTGYAWQGFVESIVGHSVSHHYV 279
            .||:.:...|              .:|..:..|.:.|:      |:.|..|:::::. ||.....
Mouse   297 ELETHLANATVPQEKRHDVTALYHRMDLMELQERFGLK------GFNWTLFIQNVLS-SVEVELF 354

  Fly   280 MQAQ----NAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDF--------IDSNEHI------ 326
            ...:    ...|...|:.::||..|..:.||::.|.||..|...        :|..:.:
Mouse   355 PDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVE 419

  Fly   327 -----DCVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSE 386
                 :||:.:..||..|...||.:|    |..:.....|.::.|::|..|:..::|  |....|
Mouse   420 EVRWRECVSYVNSNMESAVGSLYIKR----AFSKDSKSTVRELIEKIRSVFVDNLDE--LNWMDE 478

  Fly   387 QNSMVATKAQHVVLNI-------------GNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNL 438
            ::.   .|||...:||             .|.....::.|..  .||||        |....|..
Mouse   479 ESK---KKAQEKAMNIREQIGYPDYILEDNNKHLDEEYSSLT--FYEDL--------YFENGLQN 530

  Fly   439 LEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIF 503
            |:...::.:.:|.:..   |:..::..   |.....:|....|.||.|.|:||.|||:.|.....
Mouse   531 LKNNAQRSLKKLREKV---DQNLWIIG---AAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSL 589

  Fly   504 KYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCL--------------- 553
            .:..:|.|:.||:.|..|..|..:|:.||:.:.....|:. .|....||:
Mouse   590 NFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSAR-HFQQQSQCMIYQYGNFSWELADNQ 653

  Fly   554 NRNSTQYLDERIADIAGLDLAYSTYF---------QNSSQMSLTDFTTIPPQQIFFLNLAQFFCG 609
            |.|....|.|.|||..|:..||..|.         |....::||      ..|:||:|.||.:||
Mouse   654 NVNGFSTLGENIADNGGVRQAYKAYLRWLADGGKDQRLPGLNLT------YAQLFFINYAQVWCG 712

  Fly   610 DGDP------INFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            ...|      |....|...:.|:...|.....|.|||.||..|  :..::|::|
Mouse   713 SYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	163/735 (22%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	165/745 (22%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	163/735 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010