Protein Alignment Nepl6 and Kel

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_115929.3
• Gene: Kel / 23925
• MGIID: 1346053
• Length: 713
• Species: Mus musculus
• Alignment Length: 750
• Identity: 142/750 - (18%)
• Similarity: 263/750 - (35%)
• Gaps: 192/750 - (25%)

  Fly     6 CLFIVPICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPFTEIIQM 70
            |....|:|             ..|:::.|:......:.|..:|.:||.|  .....|.|    |.
Mouse    56 CPCETPVC-------------MELLDHYLASGNRSVAPCTDFFSFACEK--ANGTSDSF----QA 101

  Fly    71 LDHKVNGNLVQLMHELHQRSQSPG-FNESSVEAKVLHFYRTCR-----EAPPSTRKMEHYLRLAP 129
            |..:....|.:|:       ::|| ::..|.|.|...||.:|.     ||..|...::....|.
Mouse   102 LTEENKSRLWRLL-------EAPGSWHLGSGEEKAFQFYNSCMDTDAIEASGSGPLIQIIEELG- 158

  Fly   130 PGQALTWPQFMPRGEPWPKAQFK-----WMKSLGHLYRYGFTNVLVN---------VLVLRSSEN 180
             |..:|       |. |....|.     .|...||   :.|....:.         ::.:...|
Mouse   159 -GWNIT-------GN-WTSLDFNQNLRLLMSQYGH---FPFFRAYLRPHPAPPHTPIIQIDQPE- 210

  Fly   181 SNRFRLDISMPSLEGD---AQHLGGFLSTLATL-QIIG--------------VPTKSILPLVRKI 227
                 .||.:...:..   ||.|..:::.|..| .::|              |.|..:...:|..
Mouse   211 -----FDILLQQEQEQKVYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQ 270

  Fly   228 RRLESAIRVLTEVDDDDESETWTLRQWEYKTGYAWQGFVESI-VGHSVSHHYVMQAQNAKYFTGL 291
            ::.::..::...|..|:..        |......|...:::| ...|::....:...:..|...:
Mouse   271 QQQQAQDKLFHVVTIDELQ--------EMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNM 327

  Fly   292 KRLMDSTDAEVVANY---IMTRFVLYLIDDF---IDS---NEHIDCVTDMRRNMNLASNLLYKER 347
            .:|::    |.:.|:   |.:..:|.|:|..   :|:   ....:.:.::|:         .|||
Mouse   328 SQLVE----EGLLNHRESIQSYMILGLVDTLSPALDTKFQEARRELIQELRK---------LKER 379

  Fly   348 ------------------FLDPATLQQYTQE---------VTKVFEQLRRQFLLQINENRLGLTS 385
                              |.:|.....:.:|         ..::|.:::...::::  .:|...|
Mouse   380 PPLPAYPRWMKCVEQTGAFFEPTLAALFVREAFGPSIQSAAMELFAEIKDAVIIRL--KKLSWIS 442

  Fly   386 EQNSMVA-TKAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQ 449
            |:....| .|...:.:.:| .|:........::.|.|:... |.|  .:..|:.:.....:.|..
Mouse   443 EETQKEALNKLAQLQVEMG-APKRAVKPDIATQEYNDIQLG-PSF--LQSFLSCVRSLRARNVQS 503

  Fly   450 LNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAH 514
            ..|..|      |....|:......||.:..:::|.|.||||.|||.........:...|.::||
Mouse   504 FLQPFP------YHRWQKSPWEVNAYYSISDHMVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAH 562

  Fly   515 ELMHSVDTVGLYYDRY--GNIHEIGPQISSSPRFVAGLQCLNR-------------NSTQYLDER 564
            ||:|      ::|...  |........:...     .|.||.|             |.:..|.|.
Mouse   563 ELLH------IFYQLLLPGGCPACDTHVLQE-----ALLCLERHYAAFPLPSISSFNGSHTLLEN 616

  Fly   565 IADIAGLDLAYSTY----FQNSSQMSLTDFTTIPPQQIFFLNLAQFFC---GDGDPINFVGHDND 622
            .|||.|:.:|:..|    .:::.:::|.:. .:.|.|:||.:.||..|   ...||.:  .|...
Mouse   617 AADIGGVAIAFQAYSKRIVEHTGELTLPNL-DLSPYQLFFRSYAQVMCRGLSSQDPQD--PHSPP 678

  Fly   623 ETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            ..|:...|:....|.:.|.||..:  |...:|:||
Mouse   679 SLRVHGPLSNTPDFAKHFHCPRGTLLNPSARCKLW 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	133/705 (19%)
Kel	NP_115929.3	M13	78..711	CDD:341056	134/711 (19%)