Protein Alignment Nepl6 and ECE1

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 751
• Identity: 183/751 - (24%)
• Similarity: 301/751 - (40%)
• Gaps: 158/751 - (21%)

  Fly     3 LIACLFIVPI---CAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPF 64
            |:|||..:.|   ..:|:....||..:  :.::|||.:......|..:|.||||.:.   :.:|.
Human    88 LVACLAALGIQYQTRSPSVCLSEACVS--VTSSILSSMDPTVDPCHDFFSYACGGWI---KANPV 147

  Fly    65 TE-------IIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKME 122
            .:       ...:.:|    |...:.|.|...:.|    .|..|.|...:||.|..   .||..|
Human   148 PDGHSRWGTFSNLWEH----NQAIIKHLLENSTAS----VSEAERKAQVYYRACMN---ETRIEE 201

  Fly   123 HYLRLAP--------PGQALTWPQFMPRGEPWPKAQFK-WMKSLGHLYRYGFTNVLVNVLVLRSS 178
              ||..|        .|..:|        .||.|..|: .::.:...||   |:...:|.|...|
Human   202 --LRAKPLMELIERLGGWNIT--------GPWAKDNFQDTLQVVTAHYR---TSPFFSVYVSADS 253

  Fly   179 ENSNR--FRLD---ISMPSLE------GDAQHLGGFLSTLATLQII--GVPTKSILPLVRKIRRL 230
            :|||.  .::|   :.:||.:      .:.:.|.|:|:.:..|..:  |...::|.|.:::|...
Human   254 KNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDF 318

  Fly   231 ESAIRVLT---EVDDDDESETWTLRQWEYKT---GYAWQGFVESI---VGHSVSHHYVMQAQNAK 286
            |:|:..:|   |...|:|.....:...|.:|   ...|..|:.:|   |..:.|...|:  .:.:
Human   319 ETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV--YDKE 381

  Fly   287 YFTGLKRLMDSTDAEVVANYIMTRFV----LYLIDDFIDSNEHI----------------DCVTD 331
            |...:..|:::||..::.||::...|    .:|...|.|::|..                .||:|
Human   382 YLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSD 446

  Fly   332 MRRNMNLASNLLYKERFLDPATLQQYTQEV-TKVFEQLRRQFLLQINENRLGLTSEQNSMVATKA 395
            ...|:..|...::.:     ||..:.::.: |::..::::.|  :.:.:.|....|:....|.:.
Human   447 TENNLGFALGPMFVK-----ATFAEDSKSIATEIILEIKKAF--EESLSTLKWMDEETRKSAKEK 504

  Fly   396 QHVVLNIGNLPRGRDHRSFVSRHYE-DLVF----PLPDFDYAREHLNLLEFRTRKQVLQLNQSAP 455
            ...:.|:...|      :|:....| |.||    .:||. |....:....|..|....|| :.||
Human   505 ADAIYNMIGYP------NFIMDPKELDKVFNDYTAVPDL-YFENAMRFFNFSWRVTADQL-RKAP 561

  Fly   456 TPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSV 520
            ..|::     ..|......||....|.||.|.|:||.||:...|.....:..:|.|:.|||.|:.
Human   562 NRDQW-----SMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAF 621

  Fly   521 DTVGLYYDRYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY------------LDERIADIAGL 571
            |..|..||:.||:.   |  :.||...|....:|:....:.|            |.|.|||..||
Human   622 DDQGREYDKDGNLR---PWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGL 683

  Fly   572 DLAYSTY----FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG--------DG---DPINFVGHDN 621
            ..||..|    .:|.::.||... .:...|:|||..||.:|.        :|   ||     |..
Human   684 KAAYRAYQNWVKKNGAEHSLPTL-GLTNNQLFFLGFAQVWCSVRTPESSHEGLITDP-----HSP 742

  Fly   622 DETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            ...|:...|:....|.|.|.||..|  |.|.||::|
Human   743 SRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	169/700 (24%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	170/706 (24%)