DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and nep-2

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	757	Identity:	166/757 - (21%)
Similarity:	287/757 - (37%)	Gaps:	185/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ICAAP---TTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRH---RDDPFTEIIQM 70
            :|.:|   .|.:|           |||.:......|..::::|||::...|   .|.|.....:.
Worm    52 VCLSPGCIKTASV-----------ILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFEN 105

  Fly    71 LDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHYLRLAPPGQALT 135
            |...:...|.:|:.|    :..|...|:|...|..:||..|..   .:..::::        ..|
Worm   106 LGQDLEFALKELLDE----NDEPYDYETSAVGKAKYFYNLCLN---ESEILDNW--------RTT 155

  Fly   136 WPQFMPRGEPWPKAQFKWMKSLGH----------LY-----RYGFTNVLVNVLVLRSSENSNRFR 185
            :.:.:.....||        ||||          ||     ::. .:.|....|....:||.|..
Worm   156 FDEVVKSFGGWP--------SLGHQMKPDASIEMLYADMVAKFK-ADSLFKATVQPDDKNSQRHV 211

  Fly   186 LDISMPSLEGDAQHLGGFLST-----LATLQIIGVPTKSILPLV-----------RKIRRLESAI 234
            |.|..|.|...|:..  :::.     :|.||:|    :.:|.|:           ::|...|:|:
Worm   212 LLIDQPQLNLFARDF--YVAAENEERMAYLQLI----RDVLILLDADRTRATLDAKEIIDFETAL 270

  Fly   235 RVLTEVDD--DDESETWT-LRQWEYKTG---YAWQGFVESIVGHSVSHHYVMQAQNAKYFT---- 289
            ..:|..|:  .|.:|.:| :...|.:..   :.|..|...:...       :..:|.|..|
Worm   271 ANITMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKD-------LHEKNGKRITFDDN 328

  Fly   290 ---------GLKR---LMDSTDAEVVANYI------------------MTRFVLYLIDDFIDSNE 324
                     .|:|   |:...|..::.||:                  :|.|..|...:.::..:
Worm   329 TEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQK 393

  Fly   325 ---HIDCVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFL-LQINENRLGLTS 385
               | .|||.:...|.:|::.:|.:...|....||..:.::.:.|    .|: |.::|:  .||.
Worm   394 VRWH-GCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIME----SFVDLLLSED--WLTK 451

  Fly   386 EQNSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYEDL-VFPLPDFDYAREHLNLLEFRTRKQVLQ 449
            |.......|...:...|| .|...:..:.|:..|:.. |:|   ..|.:...:..| :.::.||:
Worm   452 ETKQTAKQKVNEMKRKIG-YPDYLNDPAAVNNEYKTFKVYP---GHYYQTKFSFYE-QYQRDVLE 511

  Fly   450 LNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAH 514
            ....|...:.:.     ..|.....:|....|.|:.|.|:||..|::.|......:..:|.|:.|
Worm   512 RITEAVDRERWV-----AGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGH 571

  Fly   515 ELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNRNSTQY-LD-------------ERI 565
            |:.|..|..|..||..|||.:.....:.| :|....||:.:..:.| ||             |.|
Worm   572 EITHGFDDRGRLYDNLGNIRQWWDNATIS-KFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENI 635

  Fly   566 ADIAGLDLAYSTYFQNSSQMSLTDFTTIPPQ---------QIFFLNLAQFFCG---DGDPINFV- 617
            ||..||..||..|.:...:.|.      ||:         |:||||.||.:||   |.:.|..:
Worm   636 ADNGGLKQAYRAYKKYEKRHSR------PPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLR 694

  Fly   618 --GHDNDETRLQQMLNGFAPFHEAFGCP--AKSNQPEKCQLW 655
              .|.....|::..|:....|.:|:.|.  ::.|..|||::|
Worm   695 TSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	157/720 (22%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	163/746 (22%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	157/721 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910