Protein Alignment Nepl6 and nep-2

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 757
• Identity: 166/757 - (21%)
• Similarity: 287/757 - (37%)
• Gaps: 185/757 - (24%)

  Fly    12 ICAAP---TTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRH---RDDPFTEIIQM 70
            :|.:|   .|.:|           |||.:......|..::::|||::...|   .|.|.....:.
 Worm    52 VCLSPGCIKTASV-----------ILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFEN 105

  Fly    71 LDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHYLRLAPPGQALT 135
            |...:...|.:|:.|    :..|...|:|...|..:||..|..   .:..::::        ..|
 Worm   106 LGQDLEFALKELLDE----NDEPYDYETSAVGKAKYFYNLCLN---ESEILDNW--------RTT 155

  Fly   136 WPQFMPRGEPWPKAQFKWMKSLGH----------LY-----RYGFTNVLVNVLVLRSSENSNRFR 185
            :.:.:.....||        ||||          ||     ::. .:.|....|....:||.|..
 Worm   156 FDEVVKSFGGWP--------SLGHQMKPDASIEMLYADMVAKFK-ADSLFKATVQPDDKNSQRHV 211

  Fly   186 LDISMPSLEGDAQHLGGFLST-----LATLQIIGVPTKSILPLV-----------RKIRRLESAI 234
            |.|..|.|...|:..  :::.     :|.||:|    :.:|.|:           ::|...|:|:
 Worm   212 LLIDQPQLNLFARDF--YVAAENEERMAYLQLI----RDVLILLDADRTRATLDAKEIIDFETAL 270

  Fly   235 RVLTEVDD--DDESETWT-LRQWEYKTG---YAWQGFVESIVGHSVSHHYVMQAQNAKYFT---- 289
            ..:|..|:  .|.:|.:| :...|.:..   :.|..|...:...       :..:|.|..|
 Worm   271 ANITMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKD-------LHEKNGKRITFDDN 328

  Fly   290 ---------GLKR---LMDSTDAEVVANYI------------------MTRFVLYLIDDFIDSNE 324
                     .|:|   |:...|..::.||:                  :|.|..|...:.::..:
 Worm   329 TEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQK 393

  Fly   325 ---HIDCVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFL-LQINENRLGLTS 385
               | .|||.:...|.:|::.:|.:...|....||..:.::.:.|    .|: |.::|:  .||.
 Worm   394 VRWH-GCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIME----SFVDLLLSED--WLTK 451

  Fly   386 EQNSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYEDL-VFPLPDFDYAREHLNLLEFRTRKQVLQ 449
            |.......|...:...|| .|...:..:.|:..|:.. |:|   ..|.:...:..| :.::.||:
 Worm   452 ETKQTAKQKVNEMKRKIG-YPDYLNDPAAVNNEYKTFKVYP---GHYYQTKFSFYE-QYQRDVLE 511

  Fly   450 LNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAH 514
            ....|...:.:.     ..|.....:|....|.|:.|.|:||..|::.|......:..:|.|:.|
 Worm   512 RITEAVDRERWV-----AGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGH 571

  Fly   515 ELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNRNSTQY-LD-------------ERI 565
            |:.|..|..|..||..|||.:.....:.| :|....||:.:..:.| ||             |.|
 Worm   572 EITHGFDDRGRLYDNLGNIRQWWDNATIS-KFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENI 635

  Fly   566 ADIAGLDLAYSTYFQNSSQMSLTDFTTIPPQ---------QIFFLNLAQFFCG---DGDPINFV- 617
            ||..||..||..|.:...:.|.      ||:         |:||||.||.:||   |.:.|..:
 Worm   636 ADNGGLKQAYRAYKKYEKRHSR------PPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLR 694

  Fly   618 --GHDNDETRLQQMLNGFAPFHEAFGCP--AKSNQPEKCQLW 655
              .|.....|::..|:....|.:|:.|.  ::.|..|||::|
 Worm   695 TSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	156/715 (22%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	157/721 (22%)