DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and nep-22

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	787	Identity:	149/787 - (18%)
Similarity:	268/787 - (34%)	Gaps:	197/787 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TTQNVEADPN-SRLMNNILSYVAEDSSACGTYFQYACGKYAVRHRDDPFTEIIQMLDHK------ 74
            |...|...|: ::..|.:|:.:.:....|..::.:.|.|: :::.|      :|.|...
Worm    58 TPGTVNTSPSYTQAANYLLNGLDDTVDPCQDFYAFTCNKF-LQNTD------LQKLGRSRLGTYD 115

  Fly    75 -----VNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCRE--APPSTRKMEHYLRLAPPGQ 132
                 |...:|..:.::...|.:....|...:|.    :.||:.  |.|:.:....|..:.....
Worm   116 QAQVDVYSEIVAALSKIDVTSTTTSKTERITKAA----FETCKNNLASPADKTAVVYAEITSLFG 176

  Fly   133 ALTWPQFMPRGEPWPKAQFKWMKSLGHLYRYGFTNVLVNVLVLRSSENSNRFRLDISMP--SLEG 195
            .:  |.|   |||.......||.: |.:.:......|...:.....::..:..|....|  ||..
Worm   177 GV--PFF---GEPLKTNVDYWMVA-GQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLAR 235

  Fly   196 D--------------AQHLGGFLSTLATLQIIGVPTKSILPLVRKIRRLESAIRVLTEVDDDDES 246
            |              ...:...|:..|......|...::|...:::...|..|.:.:..||
Worm   236 DFYVKPQYIAEVNQRVSDVNDLLTAFANAAKKNVGADALLAAAQEVVNFEVQIAMASWPDD---- 296

  Fly   247 ETWTLRQWEYK----------TGYA---WQGFVESIVGHSVSH-----HYVMQAQNAKYFTGLKR 293
               .||.::.:          |.|.   |:.::..:. |.|:.     :|.:......||..|..
Worm   297 ---LLRNYQQQYNPYNIASATTAYRAINWKSYLGQLF-HGVASDADQANYNIVVTEPSYFAWLNS 357

  Fly   294 LMD--STDAEVVANYIMTRFVLYLID--DFI---------DSNEHIDCVTDMRRNMNLASNLLYK 345
            :.|  ::::.|||||::.:.   |.|  |||         |:| :|.......|.:.......|:
Worm   358 VFDGKTSNSTVVANYMIAQL---LADESDFINPATAKVSSDTN-YIHYALRNGRGIKKIGKREYR 418

  Fly   346 ERFLDPAT------LQQY------------TQEVTKVFEQLRRQFLLQINENRLGLTSEQNSM-- 390
            ...||..:      |..|            ..|..||...::.|..|.|| |..|:....|.|
Worm   419 MADLDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVKDQTTLIIN-NFQGMIDSLNWMDT 482

  Fly   391 -----VATKAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFD-------YAREHLNLLEFRT 443
                 ...|:..:|.|.|               :.:.:|  .||:       |.:::.::::..|
Worm   483 FSKNRAHNKSDSLVKNFG---------------WPEAMF--GDFNDFTTVDAYNQDYASIIDLYT 530

  Fly   444 RKQ-----VLQLNQSAPTPDEFF-YLSDP--KTAMSSGP-----YYLMRLNIIVVPHGLLQEPFF 495
            :.:     :..:.:......||| .:.:|  :|.....|     :|....|.|..|:.....|::
Worm   531 KDKNDIYGIFAVLKKGMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITFPYAAWNPPYY 595

  Fly   496 AADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHE-----------------------IG 537
            ..:....:.::..|....|||.|..|..|:.:...|.:.:                       :.
Worm   596 NLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVV 660

  Fly   538 PQISSS--PRFVAGLQCLNRNSTQYLDERIADIAGLDLAYSTYFQ-------NSSQMSLTDFTTI 593
            .|.|:.  |.....:.|.|..:||  .|.|||:.|...||.:|.|       ...:..|......
Worm   661 TQFSTQCCPEKTGNIHCANGATTQ--GENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENY 723

  Fly   594 PPQQIFFLNLAQFFCGDGDPINFV------GHDNDETRLQQMLNGFAPFHEAFGCPAKSNQ-PE- 650
            .|.|||::.....:|......|.|      .|...:.|..|::.....|.:.|||...|.. ||
Worm   724 TPNQIFWITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEP 788

  Fly   651 --KCQLW 655
              :|::|
Worm   789 SGRCKVW 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	142/757 (19%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	144/767 (19%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	142/758 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910