Protein Alignment Nepl6 and nep-21

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 750
• Identity: 152/750 - (20%)
• Similarity: 291/750 - (38%)
• Gaps: 138/750 - (18%)

  Fly    11 PICAAP-TTQNVEADPNSRLMNNIL----------SYVAEDSSA----CGTYFQYACGKYAVRHR 60
            ||...| ...:|..|.:::..|:::          .::||:.::    |..::::|||.|.:...
 Worm   148 PIYPLPFENSSVAVDRSAKNHNDVVCTSRECVRLAGFLAENLNSKINPCEDFYEFACGNYGLNKN 212

  Fly    61 ---DDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSP-GFNESSVEAKVLHFYRTC--REAPPSTR 119
               :.|....|..:..::|..:..::       ||| ..||...:.....:|:.|  .|...||
 Worm   213 LPANKPLRHTISDVQSRLNKQVKSML-------QSPISANEKPWDKVAKGYYQKCLDEEELEST- 269

  Fly   120 KMEHYLRLAPPGQALTWPQFMPRGEPWPKAQFKWMKSLGHLYRY-GFTNVLVNVLVLRSSENSNR 183
            .:|....:|.  :...||..  .|:.|.:....|.:.:..:... |...|::.:.|.....||:|
 Worm   270 GVEAMRDIAK--RIGGWPTL--EGDKWQEWSHSWEEQIALVLNLTGVNAVILEMAVTHDPSNSSR 330

  Fly   184 FRLDISMPSLEGDAQ--HLGGF-------LSTLATLQIIGVPTKSILPLVRKIRRLESAIRVLT- 238
            ..:::..|.....::  :|.|.       .:||..:..:.:.....:........:|..::::.
 Worm   331 SVIELDQPKWGAGSRYPYLSGANDPMLRNYTTLMKMTAVALGADPAIAEKEMNEAMEFELKLVNF 395

  Fly   239 EVDD----DDESETWTLRQWEYKTGYAWQGF-------VESIVGHSVSHHYVMQAQNAKYFTGLK 292
            ..||    |.|........|:.|:.:.:..|       .:.:|..|.:|..::  :...||.|::
 Worm   396 SADDMVRRDPERGNNRFELWQLKSVFPFINFEKYLKTVFKELVALSPNHTVIV--REIDYFVGIQ 458

  Fly   293 RLMDSTDAEVVANYIMTRFV-------LYLIDDFIDSNEH----------------------IDC 328
            .::.||...|:||||..|.|       .:....|:..:..                      .||
 Worm   459 HVLQSTPKRVLANYISWRLVQGGPTGDYFSFSPFLPPSAREPFYQFKANQTGMFNSPPPDRWEDC 523

  Fly   329 VTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVAT 393
            ||.....|::....|:.|.|.:.   ::..:::|::...|:.:|:.|::.  |....|.....|.
 Worm   524 VTLSVIMMDMPVGRLFVENFFEK---ERAMKKMTELTSYLKNEFIKQLHV--LDWMDEITRRRAI 583

  Fly   394 KAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTR-----KQVLQLNQS 453
            ...:::......|....:.:::.:::..::.|       ||:|..|..|.:     :::|:|:|.
 Worm   584 SKANMIEYKSGFPMVLFNDTWMEKNWGMIIKP-------REYLLHLTIRVKLVRFTEELLRLDQP 641

  Fly   454 APTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMH 518
            .   |...:...|...   ..||....|.::.|.|::|.||......:...|.::|.|:.||:.|
 Worm   642 L---DRSMWFQSPAQV---DAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSH 700

  Fly   519 SVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNR--------------NSTQYLDERIADIA 569
            :.|..|..||..||:::.. ...:..:|:...:|..|              |....|.|.|||..
 Worm   701 AFDDQGGQYDEMGNLNDWW-DAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNG 764

  Fly   570 GLDLAYSTY------FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCGDGDPINFVG------HDND 622
            |:..|::.|      ....|:.:|..|.....||:|||..|..:|....|.:::.      |...
 Worm   765 GVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPS 829

  Fly   623 ETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            :.|....|.....|.:||.||..|  |...|||:|
 Worm   830 KYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	140/695 (20%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	141/701 (20%)