DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and nep-17

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	786	Identity:	165/786 - (20%)
Similarity:	278/786 - (35%)	Gaps:	193/786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IVPICAAP-TTQNVEADPNSRLMN---NILSYVAEDSSA----CGTYFQYACGKYAVRHRDDPFT 65
            :||  .|| |:.||:.      ||   ..:.|.|:..:.    |..::.||||.         |.
Worm   852 VVP--EAPITSTNVDK------MNAYQMAVDYYAKSVNTAIDPCDDFYSYACGN---------FN 899

  Fly    66 EIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRK------MEHY 124
            :.:.....:.. |||.:..:|...:.....|.|....|....|..|..|..|::.      .::|
Worm   900 QSVSFYTARAQ-NLVYMAQKLEDPTYQTTINSSPALKKEKQLYNACLTATASSQSEDQILISKNY 963

  Fly   125 LRLAPP------GQALTWPQFMPRGEPWPKAQFKWMKSLGHL-YRYGFTNVLVNVLVLRSSENSN 182
            ::....      ||..|   .:..|.|...:..:...:||:| :..|...::..::.....:||.
Worm   964 IQTKVDDLKTLIGQDFT---LVNGGAPKLPSAKQIGDALGYLSFEQGIDTLISPLVDTYWIDNSK 1025

  Fly   183 RFRLDISMPSLEGDAQHLG---------------------GFLSTLATLQIIGVPTKSILPLVRK 226
            .:::.|     :.:..:|.                     ..::..|..|.|.:|. ....|:..
Worm  1026 GYQMFI-----DQNTAYLSKTYYQPAAWKIEKPKYLKMALDVVTRYAREQNITLPA-GASDLLSN 1084

  Fly   227 IRRLESAIRVLTEVDDDDESE---TWTL-RQWEYKTGY---AWQGFV----ESIVGHSVSHHY-- 278
            :...|..|.|....||:...:   :|.| :..:..|.|   .|..::    .::.......:|
Worm  1085 VLDYEQNIAVKYSTDDNTRRQFQRSWNLTKTSDLVTKYNFMDWMTYLSHAPNAVKAKITDANYQV 1149

  Fly   279 -VMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVL--------Y------LIDDFI-------- 320
             ||:.....:|:. ..|..|  .|::.|.:..|.:|        |      :.|:.|
Worm  1150 SVMEVDRLTHFSA-DYLQQS--PELLVNLLFVRLLLGNAQYIPSYASAFRGMTDESIFLGLSRRK 1211

  Fly   321 DSNEHIDCVT-DMRRN----MNLASNLLYKERFLDPATLQQY----TQEVTKVFEQLRRQ---FL 373
            ....||.... |:..|    .::|:||:   :|.:......|    .|:||.:    |:.   .:
Worm  1212 TIPNHIPPPNFDLEANGPACASVANNLM---QFANGRVFVDYMYPTAQDVTNI----RKSAGGII 1269

  Fly   374 LQINENRLGLTSEQNSMVA-------TKAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDY 431
            ..:..:..|:..:.:.|..       .|...:..||. .|....:.:.:..:|..||....| ::
Worm  1270 KNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNIA-FPDWIKNDTLLGNYYSTLVIADSD-NF 1332

  Fly   432 AREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFA 496
            ...:..|::|....|..|||  |...|...:|..|.|.   ..:|...||.|..|.|:|..|:|.
Worm  1333 YDIYDKLIKFNIFVQYNQLN--AAQTDRTDFLGQPGTV---NAWYQPELNSITFPAGILVPPYFN 1392

  Fly   497 ADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGL----QC-LNR- 555
            .:......|..:|.|..|||.|..|..|:.:...||:.......|     :||.    || :|.
Worm  1393 PNWPPSINYGGMGLVAGHELTHGFDDQGVQWGPTGNLARWMDDNS-----MAGFKNMSQCVINEY 1452

  Fly   556 ------NSTQY----------LDERIADIAGLDLAYSTYFQNSS----QMSLTD--FTTIPPQQI 598
                  |:|.|          ..|.|||..|:..|::.|..:.|    ...|.|  |......|:
Worm  1453 SGFCPLNATNYSPNCVKGPQTQGENIADNGGVHAAFNAYKTHQSLDGPDPRLPDRLFGQFTHDQL 1517

  Fly   599 FFLNLAQFFC-----GDG-------DPINFVGHDNDETRLQQMLNGFAPFHEAFGCP--AKSNQP 649
            ||::.||.:|     .|.       ||     |.....|:...:..|..|..||.||  :||...
Worm  1518 FFMSFAQVWCEVRRTDDALYTQIMVDP-----HSPSMYRVYGTIQNFPAFQTAFNCPLGSKSAPE 1577

  Fly   650 EKCQLW 655
            :.|::|
Worm  1578 QHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	152/745 (20%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	153/748 (20%)
		M13	884..1581	CDD:189000	152/742 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010