Protein Alignment Nepl6 and nep-1

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 816
• Identity: 171/816 - (20%)
• Similarity: 282/816 - (34%)
• Gaps: 232/816 - (28%)

  Fly     1 MWLIACLFIVPICA-------AP----------TTQNVEADPNSRLMNNILSYVAEDSSA----- 43
            ::||:|..:: :|.       ||          ||...:...|:.:.....:|...||..
 Worm    10 VFLISCYALI-LCGTVDALPRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGDSEGYQEAS 73

  Fly    44 -------------CGTYFQYACGKYAVRHR-DDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPG 94
                         |..:|:|||..:...|. .|..|...|..  .....::..|.:|::.:.|..
 Worm    74 RLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFT--ATREKVLAEMRKLYEDNTSIP 136

  Fly    95 FNESSVEAKVLHFYRTCRE--------APPSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQF 151
            .::|.  |.:...|.||.:        |.....|::.|      |.   ||  |...|.|.::.|
 Worm   137 TSKSI--ALIKQIYNTCMDTEKHNAVGARDLLEKIKTY------GY---WP--MVHNEKWRESTF 188

  Fly   152 KWMKSLGHLYRYGFTNVLVNVLVLRSSENSNRFRLDISMPSLEGDAQHLGGFLSTLATLQIIGVP 216
            ...|.|.:..:....:|..:......|.|.:| ||      |..|...||           :|..
 Worm   189 DLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSR-RL------LSFDQGSLG-----------LGYS 235

  Fly   217 TKSIL---------------PLVRKIR-------------RLESAIR------------VLTEVD 241
            |:...               ..:.|:|             ::||.:.            ::.|.|
 Worm   236 TRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVAEED 300

  Fly   242 DDDESETWTLRQW----EYKTGYAWQGFVESIVGHSVSHHYV-----MQAQNAKYFTGLKRLMDS 297
            ..:.::.:.:|::    ||.:...|:....|.....| |.|:     :...:.:|...:..|:.:
 Worm   301 RRNYTKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLV-HSYLKTNPSIIISDVEYLQKMNTLLQN 364

  Fly   298 TDAEVVANYIMTRFVLYLIDDFIDSNEHI-------------------DCVTDMRRNMNLASNLL 343
            ||..:|.|||:.|:......:.....|.:                   |||:.....::.||..:
 Worm   365 TDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSM 429

  Fly   344 YKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQHVVLNIGNLPRG 408
            |..::.|..........:|.:.|..|.  ::..|:   .:.:|.......||..::..||
 Worm   430 YVRKYFDANAKNTTLDMITDLQEAFRN--MMHAND---WMDAETKKYALEKADQMLKQIG----- 484

  Fly   409 RDHRSFVSRHYEDLVFPLPDFDYAREHLN----LLEFRTRKQVLQL-NQSAPTPDEFFY--LSDP 466
                             .|||....|.|:    .||........|| .:|....:.|:|  |.:|
 Worm   485 -----------------YPDFILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFYYRRLLEP 532

  Fly   467 -------KTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVG 524
                   .:|.....:|....|.|..|.|:||:|||.|.......|..:|.|:.||:.|..|..|
 Worm   533 VNRFEFISSAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTG 597

  Fly   525 LYYDRYGNIHEIGPQISSSPRFVAGLQCLNRNSTQYLD-----------------ERIADIAGLD 572
            ..:|..||:.:.....:|| :|....||:   ..||.|                 |.|||..|:.
 Worm   598 RQFDNVGNLRDWWDNTTSS-KFNERTQCI---IEQYADVKLRGTDLRINGKLTQGENIADNGGIK 658

  Fly   573 ---LAYSTYFQ--NSSQMSLTDFTTIPPQQIFFLNLAQFFCGD-----------GDPINFVGHDN 621
               .||.:|.:  ...:..|..|.::..:|:||:..||.:||.           .||     |..
 Worm   659 QAFKAYKSYLEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDP-----HSP 718

  Fly   622 DETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            :..|:..:|.....|.|||.|||.|  |..::|.:|
 Worm   719 ETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	156/731 (21%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	157/735 (21%)