DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and nep-26

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	148/789 - (18%)
Similarity:	267/789 - (33%)	Gaps:	211/789 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IACLFIVPICAAPTTQNVEADPNSRLMNNILSYVAEDSSA--CGTYFQYACGKY---AVRHRDDP 63
            |||.....  ..|.|........|||:..:      |.|.  |..::|:|||.:   :|..:.|.
Worm    93 IACFLYYQ--TLPCTSEECVMTASRLLKRV------DQSVEPCDNFYQFACGGWINQSVNLKYDS 149

  Fly    64 FTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHYLRLA 128
            :..:.: .....:..:||.||:::..|.....|..  |......|..|.:.....:...|
Worm   150 WNTLYE-TQRTAHDQIVQAMHKINDGSYPLPTNAG--ERAAAKMYEQCMDTDTLEQTGLH----- 206

  Fly   129 PPGQALTWPQF-------MP-------------------------RGE--------------P-- 145
                  .|.:|       ||                         |.|              |
Worm   207 ------LWERFVDELGGWMPELKNGALEQEESFEIELDEDEKKRRRFEIEDIILSAFNYSVFPLF 265

  Fly   146 WPKAQFKWMKSLGHLY-------------RYGFTNVLVNVLVLRSSENSNRFRLDISMPSLEGDA 197
            |...:..::.|..||.             :|.:...|...::....|.          |.:....
Worm   266 WAGVEVNYLNSKEHLITIYEQLPILLAPEKYHYNKELTPEMIYGKMEG----------PPVTRAL 320

  Fly   198 QHLGGFLSTLATLQIIGVPT--KSILPLVRKIRRLESAIRVLTEVDDDDESETWT---LRQ-WEY 256
            |.:|..||.     ::|..:  :.:..::..:..||..|.:.......::.|.:|   ||: .|.
Worm   321 QQVGEELSA-----VLGFDSTDEKVRMMIANMIYLEYQITMAGSTFYKEKKERYTVVMLRELQEI 380

  Fly   257 KTGYAWQGFVESIVGHSVSHHYVMQAQNAKYFTGL-----KRLMDS-TDAEVVANYIMTRFVLYL 315
            .....|..|:..:||.::||...:..:....:..:     ::|..| :...|:.||:..:.:::.
Worm   381 APAINWHYFLSRLVGENLSHSEPIALKTGTQWIPILSAIVEKLKQSRSGVAVLKNYVKWKTIMFH 445

  Fly   316 I--------DDFI----------DSNEHIDCVTDMRRNMNLA-SNLLYKERFLDPATLQQYTQEV 361
            :        |..:          .|.....||..:.....|: .::|.|...:|..  ::..:.|
Worm   446 LAYASPKCRDGLLWMAVSLYSGAASQRKEFCVLRLSGIFPLSLPSILRKIDGIDHT--EKNVKAV 508

  Fly   362 TKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYEDLVFP- 425
            ..:.::::.::...:..:.|....|....|..|..::...||                    ||
Worm   509 QNIADRIQEKYEEMVRSSNLFSDRETRENVIDKVNNMTKFIG--------------------FPD 553

  Fly   426 --LPDFDYAREHLNLLE-------------FRTRKQVLQLNQSAPTPDEFFYLSDPKTAMS---- 471
              ..|::..:|.:.|.:             ::.|.|.|:|    |.        ||::.:.
Worm   554 AMRSDYEMEKEAVRLHDTLFWSMVLGSSSVYKERLQRLRL----PV--------DPRSWVDTRPA 606

  Fly   472 -SGPYYLMRLNIIVVPHGLLQEPFFAADSH--DIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNI 533
             |.|.:....|::.:|...|:.|:  ||.|  |...|:.:|.::.|||.|:.|..|..:...||:
Worm   607 ISVPAHNYERNLVQIPFDSLRLPY--ADEHQLDFANYAGIGTIIGHELTHAFDGQGKLHGPTGNL 669

  Fly   534 HEIGPQISSSPRFVAGLQCLNRNSTQYLD------------ERIADIAGLDLAYSTYFQNSSQMS 586
             .:.....|...|.|..||..:.....:|            |.|||..||.:||..:..|.:|.|
Worm   670 -GVWWSTDSIREFKAREQCFVKQYAGLMDSHDMNAAKEGLYENIADQVGLKVAYEAWKSNGNQNS 733

  Fly   587 --LTDFTTIPPQQIFFLNLAQFFCG-DGDPINFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS-- 646
              :.........|:|||...|.:|. .........|..:..|:...|.....|..|:.|.::|
Worm   734 GRMPGLEKYSQDQLFFLAYTQGWCALRSKSYKLQPHMEERIRMLGSLQNSPEFASAWKCSSESFM 798

  Fly   647 NQPEKCQLW 655
            |.|:||.:|
Worm   799 NPPDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	137/747 (18%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	142/767 (19%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	136/746 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010