Protein Alignment Nepl6 and nep-5

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 710
• Identity: 131/710 - (18%)
• Similarity: 243/710 - (34%)
• Gaps: 220/710 - (30%)

  Fly    34 LSYVAE-----DSSA--CGTYFQYACGKYAVRHRDDPFTEIIQML------DHKVNGNLVQLM-- 83
            :.|.||     |||.  |..:..:.|..:..|.:|  |..:::::      ||:...|:|:.|
 Worm   114 VKYSAELLELMDSSVNPCENFHHHVCNGFNPRKKD--FERLMKLINIQEKPDHRKAVNVVRRMLS 176

  Fly    84 -------HELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHYLRLAPPGQALTWPQFMP 141
                   .|:||..:.     ||:                                      .:|
 Worm   177 KCAMGKTEEIHQVGRL-----SSI--------------------------------------ILP 198

  Fly   142 RGEPWPKAQFKWMK--------SLGHLYRYGF-TNVLVNVLV----------LRSSENSN----- 182
             |.|:|.....|.|        :....|.|.| |.:|.::::          ::.|.:|.
 Worm   199 -GLPFPLLNNSWTKPSDPISTSNSSTTYSYPFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFV 262

  Fly   183 -----------RFR--LDI-----------SMPSLEGDAQHLGGFLSTLATLQIIGVPTKSILPL 223
                       :||  .||           .|..||.|.|.                ....::.|
 Worm   263 VKPFSPVLTNFKFRNMYDILKRNAPESSTNGMIDLEFDRQR----------------QLNDVIKL 311

  Fly   224 VRKIRRLE----SAIRVLTEVDDDDESETWTLRQWEYKTGYAWQGFVESIVGHSVSH-HYVMQAQ 283
            ..|:.::|    ..:..|||:.          ||...   ..|:..::|.:.:..:| ...:...
 Worm   312 QTKLEKIEFKADPEVVNLTEIQ----------RQMPI---IDWKRLIDSWIPNGYAHLKEKVYGF 363

  Fly   284 NAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDFIDSNEHIDCVTDMRRNMNLASNLLYKERF 348
            |..|:..:..::.||.:|.:.|::..||....:...:.|:....|:..:...:. ...:||...
 Worm   364 NTSYYEEINAIISSTPSETIYNFLFLRFSFKFLRTEVASDLEDTCLHQLSTTIP-GKIVLYGSE- 426

  Fly   349 LDPATLQQYTQEVTKVFEQLRRQF-LLQINENRLGLTSEQNSMVATKAQHVVLNIGNLPRGRDHR 412
             :|..|......:..:.:||:|.. .|:..::| |:...|.....||...
 Worm   427 -EPEALNLLNGMLHTIKDQLKRSLATLKWMDSR-GIEEAQKKFNKTKTVF--------------- 474

  Fly   413 SFVSRHYEDLVFPL-----PDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSS 472
            .|..   |||:..|     |:.:|.....|:|.::||.....:.::..|           ..::|
 Worm   475 GFTG---EDLIDELVGKITPESNYISTLQNVLLWQTRNMFKSVAENNVT-----------VFLNS 525

  Fly   473 GPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIG 537
            ..:|.:..|.|.:...||..||.:|:..:...::.:...:..:::|..|..|.:||..|| |...
 Worm   526 EVFYSVEKNEITISRALLHYPFMSANLPNYTNFATIASKILPQMIHIFDERGRFYDSDGN-HRNW 589

  Fly   538 PQISSSPRFVAGLQCLNRNSTQYLDERIADIAGLDLAYSTYFQNSSQMSLTDFTTIP------PQ 596
            ....:...|...:||        .|..:.::.|:.::..   .|:...:...:.|:|      .:
 Worm   590 WNTETERYFQIIVQC--------FDGMMQNVFGVSVSIG---WNAYDSTKEPYATLPGIQQSSDE 643

  Fly   597 QIFFLNLAQFFCGDGDPINFVGHDNDETRLQQMLNGFAPFHEAFGC--PAKSNQPEKCQL 654
            .:||.::.:..| ..||.|          :.:.|.....|:.||.|  ..|.|.|.||:|
 Worm   644 ALFFYSMVKTMC-TSDPDN----------VNEALASVPQFNSAFKCNNGTKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	122/687 (18%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	123/693 (18%)