Protein Alignment Nepl6 and nep-12

DIOPT Version :9

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 751
• Identity: 153/751 - (20%)
• Similarity: 278/751 - (37%)
• Gaps: 199/751 - (26%)

  Fly    28 RLMNNILSYVAEDSSACGTYFQYACGKYAVRH---RDDPFTEIIQMLDHKVNGNLVQLMHELHQR 89
            ||..:.|:.:..|::.|..::::||||||.|.   ..:....::..:..:::.:|..::.:..:.
 Worm   158 RLAASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKKEMDRHLKDILEKTSRE 222

  Fly    90 SQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHY----LRLAPPGQALT----WPQFMPRGEPW 146
            :.:.....:.:      ::.:|         |:.:    |.:.|....::    ||  :.....:
 Worm   223 NTTRSMKLAQI------YFDSC---------MDEFSQDDLGVQPLMSMISNLGGWP--LLTNARF 270

  Fly   147 PKAQFKWMKSLGHLYRYGFTNVLVNVLVLRSSENSNRFRLDISMPSLEGDAQHLGGFLS------ 205
            ....|:|....|||..||...:. .|.|..|.::|::..|..|.|.|         ||.
 Worm   271 DSIDFQWEVLAGHLALYGVDGIF-RVFVHSSFDDSDKNVLMFSPPKL---------FLEKKKFYR 325

  Fly   206 ---------------TLATLQIIGVPTK--------SILPLVRKIRRLESAIRVLTEVDDDDESE 247
                           .|:.|.::||..:        .:..::...||:.:..|:  |:..:..|.
 Worm   326 EVPSSNVYLQYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFERRIANLTRI--ELSRNHSSI 388

  Fly   248 TWTLRQWEYKTGY---AWQGFV-ESIVGH--SVSHHYVMQAQNAKYFTGLKRLMDSTDAEVVANY 306
            ...:...|:|..|   .|..|. |.:.|:  .:....|:...:..||..|..|:.|.....:.|:
 Worm   389 NNMITFGEFKRKYDKINWDAFFNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNF 453

  Fly   307 IM----TRFVLYL-------IDDF------IDSNEHI--DCVTDMRRNMNLASNLLYKERFL--- 349
            :|    :.:.:||       :.||      :.|::.:  .||.::|.|:.:..:..|.::|.
 Worm   454 LMWCLVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKK 518

  Fly   350 DPATLQQYTQEVTKVFEQ-----------LRRQFLLQINE--NRLGLTSEQNSMVATKAQHVVLN 401
            |....:...:::.|..||           .|...|::::.  :::|......:..|....:..:.
 Worm   519 DKLVAEDMIRDLKKAMEQTLLNADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYAGVR 583

  Fly   402 IGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQSAP--TPDEFFYLS 464
            :            .:..|.|....|....| |:.|:.|. ||...:   :.::|  ..|.|.|.:
 Worm   584 L------------TANQYFDNAISLKKAAY-RDALSKLH-RTPSLI---DWASPIIAVDAFHYFT 631

  Fly   465 DPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDR 529
            .               |.|:.|.|:||.|.|..|:.....|..:|..:.||:.|..|.:|..||.
 Worm   632 G---------------NEIIFPAGILQFPMFVPDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDD 681

  Fly   530 YGNIH------------------------EIGPQISSSPRFVAGLQCLNRNSTQYLDERIADIAG 570
            .||:.                        :|.||   :.|.|.|...:..|        |||..|
 Worm   682 KGNLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQ---TGRKVDGKMTIGEN--------IADNGG 735

  Fly   571 LDLAYSTYFQNSSQ-------MSLTDFTTIPPQQIFFLNLAQFFCGDGDPINFVGHDNDET---- 624
            |.:|:..|...|.:       ..||||:   |.|:|||..|..:|....| :.:.|..|..
 Worm   736 LRVAFQAYQLRSDREKETRRLPGLTDFS---PNQLFFLAYANTWCEALKP-SAIDHIMDTDVHSL 796

  Fly   625 ---RLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
               |:...|.....|.:.|.||..|  |..|||::|
 Worm   797 GMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	147/733 (20%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	147/734 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910