Protein Alignment Nepl6 and Mme

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_032630.2
• Gene: Mme / 17380
• MGIID: 97004
• Length: 750
• Species: Mus musculus
• Alignment Length: 740
• Identity: 160/740 - (21%)
• Similarity: 269/740 - (36%)
• Gaps: 167/740 - (22%)

  Fly    27 SRLMNNILSYVAEDSSA--CGTYFQYACGKYAVRH---------------RDDPFTEIIQMLDHK 74
            :||:.|:      |:|.  |..:|:||||.:..|:               ||:  .|:|
Mouse    67 ARLIQNM------DASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDE--LEVI------ 117

  Fly    75 VNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTC-REAPPSTRKMEHYLRLAPPGQALTWPQ 138
                       |....|.|...:.....|....||:| .|:...:|..:..|:|.|....
Mouse   118 -----------LKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYG----- 166

  Fly   139 FMPRGEPWPKAQFKWMKSLGHLY-----------RYGFTNVLVNVLVLRSSENSNRFRLDISMPS 192
                   ||.|...|.::.|..:           :|| ..||:|..|....:||.:..:....|.
Mouse   167 -------WPVASDNWDQTYGTSWTAEKSIAQLNSKYG-KKVLINFFVGTDDKNSTQHIIHFDQPR 223

  Fly   193 L---EGDAQHLGG-----------FLSTLATLQIIGVPTKSILPL--------VRKIRRLESAIR 235
            |   ..|.....|           |:.::|.|    :..:..||:        :.|:..||..|.
Mouse   224 LGLPSRDYYECTGIYKEACTAYVDFMISVARL----IRQEQSLPIDENQLSLEMNKVMELEKEIA 284

  Fly   236 VLTEVDDDDES-----ETWTLRQWEYK-------TGYAWQGF---VESIVGHSVSHHYVMQAQNA 285
            ..|...:|...     ...||.:.:..       ..::|..|   :.|.|..::.:...:.....
Mouse   285 NATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAP 349

  Fly   286 KYFTGLKRLMDSTDAEVVANYIMTRFVLYLID----DFIDSNEHI---------------DCVTD 331
            :|.|.||.::.......:.|.:..||::.|:.    ::.:|....               .|...
Mouse   350 EYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANY 414

  Fly   332 MRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLGLTSEQNSMVATKAQ 396
            :..||..|...||    ::.|...:....|..:..|:|..| :|..::...:.:|.......||.
Mouse   415 VNGNMENAVGRLY----VEAAFAGESKHVVEDLIAQIREVF-IQTLDDLTWMDAETKKKAEEKAL 474

  Fly   397 HVVLNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFF 461
            .:...||.......:.:.::..|.:|.:  .:.:|....:..|:|...||:.:|.:.. ..||:.
Mouse   475 AIKERIGYPDDIISNENKLNNEYLELNY--REDEYFENIIQNLKFSQSKQLKKLREKV-DKDEWI 536

  Fly   462 YLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLY 526
                 ..|.....:|....|.||.|.|:||.|||:|...:...|..:|.|:.||:.|..|..|..
Mouse   537 -----SGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRN 596

  Fly   527 YDRYGNIHEIGPQISSSPRFVAGLQCL---------------NRNSTQYLDERIADIAGLD---L 573
            :::.|::.:...| .|:..|....||:               :.|....|.|.|||..|:.   .
Mouse   597 FNKDGDLVDWWTQ-QSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR 660

  Fly   574 AYSTYFQNSSQMSLTDFTTIPPQQIFFLNLAQFFCGDGDP---INFVG---HDNDETRLQQMLNG 632
            ||..|.:.:.:..|.....:..:|:||||.||.:||...|   :|.:.   |.....|:...|..
Mouse   661 AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQN 725

  Fly   633 FAPFHEAFGCPAKS--NQPEKCQLW 655
            .|.|.:||.|...|  |...||::|
Mouse   726 SAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	152/714 (21%)
Mme	NP_032630.2	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	77..748	CDD:341056	153/720 (21%)