DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and Ecel1

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	773	Identity:	171/773 - (22%)
Similarity:	290/773 - (37%)	Gaps:	196/773 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIACLFIVPICAAPTTQNVEADPNSRLMNNILSYVAEDSSA----CGTYFQYACGKYAVRHR--D 61
            ::|..::.|..|.......|..|..:.......:::.:..|    |..::.:|||.:..||.  |
Mouse    79 MLALKYLGPGAAGGGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPD 143

  Fly    62 DPFT-EIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVLHFYRTCREAPPSTRKMEHYL 125
            |..| ..|..:..:   |..:|...|.:.:..||   .:.:.||..|:|:|.:    .|::|
Mouse   144 DKLTYGTIAAIGEQ---NEERLRRLLARPTGGPG---GAAQRKVRAFFRSCLD----MREIE--- 195

  Fly   126 RLAP----------PGQALTWPQFMPRGEPWP------KAQFKWMKSLGHLYRYGFTNVLVNVLV 174
            ||.|          .|..|......|....|.      |||..:..:           .|.::.|
Mouse   196 RLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAA-----------ALFSLTV 249

  Fly   175 LRSSENSNRF--RLD---ISMPSL-------EGDAQHLGG---FLSTLATLQIIGV-----PTKS 219
            .....||:|:  |:|   :::|..       |...:.|..   |:..|  |:::|.     ..:.
Mouse   250 SLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRL--LRLLGADAVEQKAQE 312

  Fly   220 ILPLVRKIRRLESAIRVLTEVDD--DDESETW---TLRQWEYKTGY-AWQGFVESIVGHSVSHHY 278
            ||.|.:::..:.     ::|.||  .|.|..:   ||.|.:....: .|:..::.|.....|...
Mouse   313 ILQLEQRLANIS-----VSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEE 372

  Fly   279 VMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDFIDSNEHID---------------- 327
            .:......|...:.:|:.||...::.||::.|.|:.|       :||:.
Mouse   373 EVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVL-------SEHLSSPFREALHELAKEMEG 430

  Fly   328 ----------CVTDMRRNMNLASNLLY-KERF--LDPATLQQYTQEVTKVFEQLRRQFLLQINEN 379
                      |:....|:..:|...|: .|.|  ...|.:||..:::        :..|.|..|.
Mouse   431 NDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDI--------KYILGQRLEE 487

  Fly   380 RLGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSF------VSRHYEDLVFPLPDFDYAREHLNL 438
            ...:.::..:....|.|::::.:|       :..|      |.:.||   |.:.:..|.:..||.
Mouse   488 LDWMDAQTKAAARAKLQYMMVMVG-------YPDFLLKPEAVDKEYE---FEVHEKTYFKNILNS 542

  Fly   439 LEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIF 503
            :.|..:..|.::.|..   |:..:|..|: |:::  |||...|.:|.|.|:||...:..|.....
Mouse   543 IRFSIQLSVKKIRQEV---DKSSWLLPPQ-ALNA--YYLPNKNQMVFPAGILQPTLYDPDFPQSL 601

  Fly   504 KYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNR---NSTQY----- 560
            .|..:|.::.|||.|..|..|..|||.||:.....:.|.| .|:...:|:.|   |.|.|
Mouse   602 NYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYS-HFLRKAECIVRLYDNFTVYNQRVN 665

  Fly   561 ----LDERIADIAGLDLAYSTYFQNSSQMSLTDFTTIPP--------QQIFFLNLAQFFCGDGDP 613
                |.|.|||:.||.|||..|     |..:.:.....|        .|:||:..||.:|
Mouse   666 GKHTLGENIADMGGLKLAYYAY-----QKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWC----- 720

  Fly   614 INFVGHDNDETRLQQMLNGFAPFH--------------EAFGCPAKS--NQPEKCQLW 655
               :...:....||.:.:..||.|              .||.||..|  |...||.:|
Mouse   721 ---IKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	164/730 (22%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	163/727 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910