Protein Alignment Nepl6 and EEF1AKMT4-ECE2

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_055508.3
• Gene: EEF1AKMT4-ECE2 / 110599583
• HGNCID: 53615
• Length: 883
• Species: Homo sapiens
• Alignment Length: 767
• Identity: 171/767 - (22%)
• Similarity: 284/767 - (37%)
• Gaps: 189/767 - (24%)

  Fly     3 LIACLFIVPICAAPTTQNVEADPNS---------RLMNNILSYVAEDSSACGTYFQYACGKYAVR 58
            |:.||..:.:       ....||:.         |:...||..:....|.|..::|::||.:..|
Human   192 LLGCLVALGV-------QYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRR 249

  Fly    59 H-------RDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESS-VEAKVLHFYRTCRE-- 113
            :       |.:.|..:...       |...|.|.|    ::..||.|| .|.|...||.:|.:
Human   250 NPLPDGRSRWNTFNSLWDQ-------NQAILKHLL----ENTTFNSSSEAEQKTQRFYLSCLQVE 303

  Fly   114 ------APPSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQF-KWMKSLGHLYRYG--FTNVL 169
                  |.|....:|..     .|..:|        .||.:..| :.:|::...||..  ||
Human   304 RIEELGAQPLRDLIEKI-----GGWNIT--------GPWDQDNFMEVLKAVAGTYRATPFFT--- 352

  Fly   170 VNVLVLRSSENSNRFRLDIS---MPSLE------GDAQHLGGFLSTLATLQII--GVPTKSILPL 223
            |.:.....|.|||..::|.|   :||.:      .:.:.|..:|..:..|.::  |.|| |....
Human   353 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPT-STREQ 416

  Fly   224 VRKIRRLESAIRVLTEVDD---DDE--------SETWTL---RQWEYKTGYAWQGFVESIVGHSV 274
            ::::..||..:..:|...|   |:|        ||...|   ..|     ..:..|:.|.:..|.
Human   417 MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDW-----LEFLSFLLSPLELSD 476

  Fly   275 SHHYVMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDD----FIDSNEHI--------- 326
            |...|:...:  |...:..|::.|:..::.||::...|......    |..:.|.:
Human   477 SEPVVVYGMD--YLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKK 539

  Fly   327 -------DCVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTK-VFEQLRRQFLLQINENRLG- 382
                   .|:::....:..|...|:.:     ||..:.::|:.: :..::|..|     |..||
Human   540 SCVPRWQTCISNTDDALGFALGSLFVK-----ATFDRQSKEIAEGMISEIRTAF-----EEALGQ 594

  Fly   383 --LTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFV--SRHYEDLV--FPLPDFDYAREHLNLLEF 441
              ...|:....|.:....:.::...|      .|:  .:..:|:.  :.:.:..:.:..|||..|
Human   595 LVWMDEKTRQAAKEKADAIYDMIGFP------DFILEPKELDDVYDGYEISEDSFFQNMLNLYNF 653

  Fly   442 RTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYS 506
            ..:....|| :..|:.|::     ..|..:...|||...|.||.|.|:||.||:|.:......:.
Human   654 SAKVMADQL-RKPPSRDQW-----SMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFG 712

  Fly   507 LLGFVLAHELMHSVDTVGLYYDRYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY--------- 560
            .:|.|:.|||.|:.|..|..||:.||:.   |  |..|...|.....|:.....||
Human   713 GIGVVMGHELTHAFDDQGREYDKEGNLR---PWWQNESLAAFRNHTACMEEQYNQYQVNGERLNG 774

  Fly   561 ---LDERIADIAGLDLAYSTY------FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG------- 609
               |.|.|||..||..||:.|      .....|:.....|.   .|:||:..||.:|.
Human   775 RQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTN---HQLFFVGFAQVWCSVRTPESS 836

  Fly   610 -DG---DPINFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
             :|   ||     |.....|:...|:....|...||||..|  |..:.|::|
Human   837 HEGLVTDP-----HSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	159/710 (22%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		UbiG	48..>128	CDD:441829
		M13	232..881	CDD:341056	161/716 (22%)