DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl6 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	767	Identity:	171/767 - (22%)
Similarity:	284/767 - (37%)	Gaps:	189/767 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIACLFIVPICAAPTTQNVEADPNS---------RLMNNILSYVAEDSSACGTYFQYACGKYAVR 58
            |:.||..:.:       ....||:.         |:...||..:....|.|..::|::||.:..|
Human   192 LLGCLVALGV-------QYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRR 249

  Fly    59 H-------RDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESS-VEAKVLHFYRTCRE-- 113
            :       |.:.|..:...       |...|.|.|    ::..||.|| .|.|...||.:|.:
Human   250 NPLPDGRSRWNTFNSLWDQ-------NQAILKHLL----ENTTFNSSSEAEQKTQRFYLSCLQVE 303

  Fly   114 ------APPSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQF-KWMKSLGHLYRYG--FTNVL 169
                  |.|....:|..     .|..:|        .||.:..| :.:|::...||..  ||
Human   304 RIEELGAQPLRDLIEKI-----GGWNIT--------GPWDQDNFMEVLKAVAGTYRATPFFT--- 352

  Fly   170 VNVLVLRSSENSNRFRLDIS---MPSLE------GDAQHLGGFLSTLATLQII--GVPTKSILPL 223
            |.:.....|.|||..::|.|   :||.:      .:.:.|..:|..:..|.::  |.|| |....
Human   353 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPT-STREQ 416

  Fly   224 VRKIRRLESAIRVLTEVDD---DDE--------SETWTL---RQWEYKTGYAWQGFVESIVGHSV 274
            ::::..||..:..:|...|   |:|        ||...|   ..|     ..:..|:.|.:..|.
Human   417 MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDW-----LEFLSFLLSPLELSD 476

  Fly   275 SHHYVMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDD----FIDSNEHI--------- 326
            |...|:...:  |...:..|::.|:..::.||::...|......    |..:.|.:
Human   477 SEPVVVYGMD--YLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKK 539

  Fly   327 -------DCVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTK-VFEQLRRQFLLQINENRLG- 382
                   .|:::....:..|...|:.:     ||..:.::|:.: :..::|..|     |..||
Human   540 SCVPRWQTCISNTDDALGFALGSLFVK-----ATFDRQSKEIAEGMISEIRTAF-----EEALGQ 594

  Fly   383 --LTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFV--SRHYEDLV--FPLPDFDYAREHLNLLEF 441
              ...|:....|.:....:.::...|      .|:  .:..:|:.  :.:.:..:.:..|||..|
Human   595 LVWMDEKTRQAAKEKADAIYDMIGFP------DFILEPKELDDVYDGYEISEDSFFQNMLNLYNF 653

  Fly   442 RTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYS 506
            ..:....|| :..|:.|::     ..|..:...|||...|.||.|.|:||.||:|.:......:.
Human   654 SAKVMADQL-RKPPSRDQW-----SMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFG 712

  Fly   507 LLGFVLAHELMHSVDTVGLYYDRYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY--------- 560
            .:|.|:.|||.|:.|..|..||:.||:.   |  |..|...|.....|:.....||
Human   713 GIGVVMGHELTHAFDDQGREYDKEGNLR---PWWQNESLAAFRNHTACMEEQYNQYQVNGERLNG 774

  Fly   561 ---LDERIADIAGLDLAYSTY------FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG------- 609
               |.|.|||..||..||:.|      .....|:.....|.   .|:||:..||.:|.
Human   775 RQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTN---HQLFFVGFAQVWCSVRTPESS 836

  Fly   610 -DG---DPINFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
             :|   ||     |.....|:...|:....|...||||..|  |..:.|::|
Human   837 HEGLVTDP-----HSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	161/715 (23%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	161/716 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910