DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl6 and Ece2

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_647454.2	Gene:	Ece2 / 107522	MGIID:	1101356	Length:	763	Species:	Mus musculus

Alignment Length:	761	Identity:	170/761 - (22%)
Similarity:	286/761 - (37%)	Gaps:	179/761 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIACLFIVPICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKYAVRH-------R 60
            |:.||..:.:...|.......:...|:...||..:....|.|..::|::||.:..|:       |
Mouse    74 LLGCLVALWVHRDPAHSTCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSR 138

  Fly    61 DDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESS-VEAKVLHFYRTCREAPPSTRKMEHY 124
            .:.|..:...       |...|.|.|    ::..||.|| .|.|...||.:|.::       |..
Mouse   139 WNTFNSLWDQ-------NQAILKHLL----ENTTFNSSSEAERKTRSFYLSCLQS-------ERI 185

  Fly   125 LRL-APP---------GQALTWPQFMPRGEPWPKAQF-KWMKSLGHLYRYG--FTNVLVNVLVLR 176
            .:| |.|         |..:|        .||.:..| ..:|::...||..  ||   |.|....
Mouse   186 EKLGAKPLRDLIDKIGGWNIT--------GPWDEDSFMDVLKAVAGTYRATPFFT---VYVSADS 239

  Fly   177 SSENSNRFRLDIS---MPSLE------GDAQHLGGFLSTLATLQII--GVPTKSILPLVRKIRRL 230
            .|.|||..::|.|   :||.:      .:.:.|..:|..:..|.::  |.|| |....::::..|
Mouse   240 KSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQPT-STREQMQQVLEL 303

  Fly   231 ESAIRVLTEVDD---DDE--------SETWTLRQWEYKTGYAWQGFVESIVGH-SVSHHYVMQAQ 283
            |..:..:|...|   |:|        ||...|     .....|..|:..::.. .:.....:...
Mouse   304 EIQLANITVPQDQRRDEEKIYHKMSISELQAL-----APAVDWLEFLSFLLSPLELGDSEPVVVY 363

  Fly   284 NAKYFTGLKRLMDSTDAEVVANYIMTRFV----LYLIDDFIDSNEHI----------------DC 328
            ..:|...:..|::.|:..::.||::...|    ..|...|..:.|.:                .|
Mouse   364 GTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTC 428

  Fly   329 VTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTK-VFEQLRRQFLLQINENRLG---LTSEQNS 389
            :::....:..|...|:.:     ||..:.::|:.: :..::|..|     |..||   ...|:..
Mouse   429 ISNTDDALGFALGSLFVK-----ATFDRQSKEIAEGMINEIRSAF-----EETLGDLVWMDEKTR 483

  Fly   390 MVATKAQHVVLNIGNLPRGRDHRSFV--SRHYEDLV--FPLPDFDYAREHLNLLEFRTRKQVLQL 450
            :.|.:....:.::...|      .|:  .:..:|:.  :.:.:..:.:..|||..|..:....||
Mouse   484 LAAKEKADAIYDMIGFP------DFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQL 542

  Fly   451 NQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHE 515
             :..|:.|::     ..|..:...|||...|.||.|.|:||.||:|.:......:..:|.|:.||
Mouse   543 -RKPPSRDQW-----SMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHE 601

  Fly   516 LMHSVDTVGLYYDRYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY------------LDERIA 566
            |.|:.|..|..||:.||:.   |  |..|...|.....|:....:||            |.|.||
Mouse   602 LTHAFDDQGREYDKEGNLR---PWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIA 663

  Fly   567 DIAGLDLAYSTY---------FQNSSQMSLTDFTTIPPQQIFFLNLAQFFCG--------DG--- 611
            |..||..||:.|         .|....:.||:      .|:||:..||.:|.        :|
Mouse   664 DNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTN------HQLFFVGFAQVWCSVRTPESSHEGLVT 722

  Fly   612 DPINFVGHDNDETRLQQMLNGFAPFHEAFGCPAKS--NQPEKCQLW 655
            ||     |.....|:...|:....|...||||..|  |..:.|::|
Mouse   723 DP-----HSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	161/718 (22%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	161/719 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010