DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl6 and LOC100332538

DIOPT Version :9

Sequence 1:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_021322193.1	Gene:	LOC100332538 / 100332538	-ID:	-	Length:	808	Species:	Danio rerio

Alignment Length:	714	Identity:	165/714 - (23%)
Similarity:	291/714 - (40%)	Gaps:	156/714 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CGTYFQYACGKYAVRH---RDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVL 105
            |..::.:|||.:..||   .|.....||..:..:....|.:|:....||.:.     .|.|.||.
Zfish   149 CHDFYSFACGGWLRRHGIPEDKLSYGIITAIGEQNQDKLQRLLQAPVQRREL-----ESAERKVK 208

  Fly   106 HFYRTC---RE-----APPSTRKMEHY----LRLAPPGQALTWPQFMPRGEPWPKAQFKWMKSLG 158
            .|||:|   :|     |.|.|..::..    |..||||.| .|..    |....:..|..|
Zfish   209 EFYRSCINIKEIDRLGAGPMTEVIDSCGGWDLSGAPPGGA-GWDS----GSAPIRPDFNEM---- 264

  Fly   159 HLYR----YGFTNVLVNVLVLRSSENSNR--FRLD---ISMPSL-------EGDAQHLGGFLSTL 207
             ||:    |. |:|..::.|....:||:|  .|:|   :::|..       |...:.|..:.:.:
Zfish   265 -LYKTQGVYS-TSVFFSLTVSVDDKNSSRNAIRIDQEGLTLPERTLYLGQDEDSVKILASYKALM 327

  Fly   208 -ATLQIIG-----VPTKSILPLVRKIRRLESAIRVLTEVDDD--DESETW---TLRQWE-YKTGY 260
             ..|.::|     :.::.||.|..|:..:     .::|.:|.  |.|..:   ||:|.: ....:
Zfish   328 ERLLSMLGAHNATLKSREILDLETKLANI-----TVSEYEDQRKDISSMYNRITLKQLQKMAPSF 387

  Fly   261 AWQGFVESIVGHSVSHHYVMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYL---------- 315
            .|:..::.|...:.|....:......|...:..::.:|...|:.||::.|.|..|
Zfish   388 HWKRLLDRIFNDNFSEEEEIVVLATDYMQTVSDIIKTTSKRVLHNYMLWRMVAALSEHLSTAFRS 452

  Fly   316 -IDDF---IDSNE-HID----CVTDMRRNMNLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQ 371
             |.:|   ||..| .:|    |:|...::..:|...|:.::....::    ..:|.::.|.::..
Zfish   453 TIHEFSREIDGTEQQLDLERLCLTQANKHFGMALGALFVQQHFSSSS----RAKVQELVEDIKHS 513

  Fly   372 FLLQINENRLGLTSEQNSMVAT-KAQHVVLNIGNLPRGRDHRSFVSRHY---EDLVFPLPDFDYA 432
            ..:::.|  |....|:....|. |.||:::..|       :..|:.:..   |:..|.:.:..|.
Zfish   514 LDVRLQE--LDWMDEETKDAARGKLQHMMVMTG-------YPDFLLKPELIDEEYAFDVNEKTYF 569

  Fly   433 REHLNLLEFRTRKQVLQLNQSAPTPDEFFYLSDPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAA 497
            :..||.:::..:..:.::::..   |:..:|..|: |:::  |||...|.:|.|.|:||...:..
Zfish   570 KNILNSIKYNIKLSIKKIHKEV---DKTTWLLPPQ-ALNA--YYLPNKNQMVFPAGILQPTLYDP 628

  Fly   498 DSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIGPQISSSPRFVAGLQCLNR---NSTQ 559
            :......|..:|.::.|||.|..|..|..||||||:.:...: .|..:|....:|:.:   |.|.
Zfish   629 EFPQSLNYGGIGAIIGHELTHGYDDWGGQYDRYGNLKQWWTE-ESYRKFQKKTECIVKLYDNFTV 692

  Fly   560 Y---------LDERIADIAGLDLAYSTYFQNSSQMSLTDFTTIPP--------QQIFFLNLAQFF 607
            |         |.|.|||:.||.|:|..|     |..:.:.....|        :|:||:..||.:
Zfish   693 YNQRVNGRLTLGENIADLGGLKLSYHAY-----QKWVREHGPERPLPGLKHTHEQLFFIAFAQNW 752

  Fly   608 CGDGDPINFVGHDNDETRLQQMLNGFAPFH----------EAFG----CPAKS--NQPEKCQLW 655
            |        :...:....||.:.:..||.|          |.||    ||..|  |...||.:|
Zfish   753 C--------MKRRSQSIYLQLLTDKHAPEHYRVIGSVSQFEEFGRVFHCPRGSPMNPVNKCSVW 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	42..653	CDD:189000	163/710 (23%)
LOC100332538	XP_021322193.1	M13	146..806	CDD:189000	163/710 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910