Protein Alignment Nepl6 and mmel1

DIOPT Version :10

• Sequence 1: NP_609023.3
• Gene: Nepl6 / 33893
• FlyBaseID: FBgn0259716
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 797
• Identity: 172/797 - (21%)
• Similarity: 290/797 - (36%)
• Gaps: 226/797 - (28%)

  Fly     1 MWLIACLFIV----------PICAAPTTQNVEADPNSRLMNNILSYVAEDSSACGTYFQYACGKY 55
            ::|:.|..:.          .||.  ||..|.|  .:|::.|:...:    ..|..::|||||.:
 Frog    53 LFLMTCAVVALLVLYTSHKESICT--TTGCVTA--AARIIQNMDPTI----EPCTDFYQYACGGW 109

  Fly    56 AVRH---------------RDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFNESSVEAKVL 105
            ..:|               ||:  .|||      :.|.|     |:..:.....|.    :||:|
 Frog   110 LNKHVIPETSSRYSIFDILRDE--MEII------LKGLL-----EMPDQEDRDAFK----KAKIL 157

  Fly   106 HFYRTCREAPPSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQFKW---------MKSLGHLY 161
              |::|...           .|.....:|...:.:.....||.|...|         ::....|.
 Frog   158 --YKSCMNE-----------SLIEQRDSLPLLELLTTVGEWPVASTDWNGTKESNWSLEEKLSLL 209

  Fly   162 RYGFT-NVLVNVLVLRSSENSNRFRLDISMPSL----------EGDAQHL-GGFLSTLATLQIIG 214
            .|.|. .|||::.|......|::..:.|..|||          :|:.|.: ..:|..:.|
 Frog   210 NYKFNKRVLVDIFVWNDDRESSKHIIYIDQPSLGMPSRDYYFNKGNYQRIREAYLQFMIT----- 269

  Fly   215 VPTKSILPLVRKIRRL--------ESAIRVLTEVDDDDESET---------------WTLRQWEY 256
                 |..:||:.|.|        |...||: :::.|....|               .||.:::.
 Frog   270 -----IARMVREDRNLTRDDSLVQEEMTRVM-DLETDIARATAPSEERNDVTLLYNKMTLLEFQQ 328

  Fly   257 K---TGYAWQGFVESIVGHSVSHHYVMQAQ------NAKYFTGLKRLMDSTDAEVVANYIMTRFV 312
            |   ..:.|..|::.::.   |.:..:||:      .|.|...||.::.:..|..:.||::.|.|
 Frog   329 KFALDDFNWTSFIQGVMS---SVNIQLQAEEEVVVYGAPYLHQLKNILSNYSASTLQNYVVWRMV 390

  Fly   313 LYLIDDF-------------------IDSNEHIDCVTDMRRNMNLASNLLY-KERFLDPATLQQY 357
            :..:...                   ::.....:||:.:..||..|...:| ||.|..     :.
 Frog   391 IDRVSSLSRRYKDARASYRKALYGTTLEEARWRECVSYVNSNMENAVGAMYVKETFAG-----ES 450

  Fly   358 TQEVTKVFEQLRRQFLLQINENR-LGLTSEQNSMVATKAQHVVLNIGNLPRGRDHRSFVSRHYED 421
            .:.::.:..::|..|:..::|.: :..||:..:  ..||..:...||               |.|
 Frog   451 KRMISDLINKVREAFIETLDELQWMDETSKDKA--REKALSIKEQIG---------------YPD 498

  Fly   422 LVFPLPD----FDYAREHLNLLEFRTRKQVLQ-LNQSA---------PTPDEFFYLSDPKTAMSS 472
            .:  |.|    .|.....||..|::..:.:|: ||..|         |...:.:.:.    |..:
 Frog   499 YI--LEDQNDKLDQETAALNFSEYQYFENILEILNSGAQKSLKKLREPVDQDAWIIG----AAVA 557

  Fly   473 GPYYLMRLNIIVVPHGLLQEPFFAADSHDIFKYSLLGFVLAHELMHSVDTVGLYYDRYGNIHEIG 537
            ..:|....|.||.|.|:||.|||.........:..:|.|:.||:.|..|..|..:|:.||:.:..
 Frog   558 DAFYSPNRNQIVFPAGILQPPFFNKHQPQALNFGGIGMVIGHEITHGFDDNGRNFDKDGNMFDWW 622

  Fly   538 PQISSSPRFVAGLQCL---------------NRNSTQYLDERIADIAGLDLAYSTYFQ------N 581
            ...|:. .|....:|:               |.:....|.|.|||..|:..||..|.:      .
 Frog   623 SNFSAM-HFKDQSRCMVYQYGNYTWELAGGQNVSGIITLGENIADNGGVRQAYKAYLKWVERHGK 686

  Fly   582 SSQMSLTDFTTIPPQQIFFLNLAQFFCGDGDP------INFVGHDNDETRLQQMLNGFAPFHEAF 640
            ..::...|.|.   :|:||||.||.:||...|      |....|...:.|:...|..|..|.|.|
 Frog   687 EPKLPGLDLTY---KQLFFLNFAQVWCGSYRPEYARHSIKTDVHSPFKYRVMGSLQNFEAFAEEF 748

  Fly   641 GCP--AKSNQPEKCQLW 655
            .|.  .|.:..|||::|
 Frog   749 NCKKGTKMHPVEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl6	NP_609023.3	M13	47..653	CDD:341056	159/737 (22%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	160/747 (21%)