DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and ECE2

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	724	Identity:	154/724 - (21%)
Similarity:	290/724 - (40%)	Gaps:	135/724 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRY-QGQMLPTDTLGLIDH 99
            :|.::...:|....|||:|||::||.| |::......|.| |......: |.|.:
Human   148 VAGKILESLDRGVSPCEDFYQFSCGGW-IRRNPLPDGRSR-WNTFNSLWDQNQAI---------- 200

  Fly   100 SVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLK------------------------PY 140
                 |:.||   ..::|.|.|...::.:.:|.||.:::                        |:
Human   201 -----LKHLL---ENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPW 257

  Fly   141 NLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLREE--VLPRWDDSRNYS 203
            :...::::|        .:|...:|...|..:......:....|.:.:.:.  .||    ||:|
Human   258 DQDNFMEVL--------KAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLP----SRDY- 309

  Fly   204 IYVNKPSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRL-----QELEDDEGPR 263
             |:|:.:.::........|.||.:.:|....:.....:||.:.|.:|..:     |..::::...
Human   310 -YLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYH 373

  Fly   264 EMQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLK 328
            :|.:..|.:..|.:.||.|:..:....||.....:::..:.||:.:|:|:....|..:.:|::
Human   374 KMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLI-- 436

  Fly   329 WLAFLKQQGPAD---------------------ISRGE-CVAALRRAMPLASSWLVGQQFSDPES 371
            |....|.....|                     :.|.: |::....|:..|...|..:...|.:|
Human   437 WNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQS 501

  Fly   372 ESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDVEQYHV 432
            :.....:...::..|.:.|.: .:.:........::|..|:...:||    .:.:|::||...:
Human   502 KEIAEGMISEIRTAFEEALGQ-LVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGY- 564

  Fly   433 RIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSP-----LYV 492
              ::|..||:.|.|                |:.||:....::......|.:..:.:|     .|:
Human   565 --EISEDSFFQNML----------------NLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYL 611

  Fly   493 RPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGA 557
            ..:|.::.|.|:||.|.:.||.........:|.|:.|||.|.||..|.:||..||:. |..:..:
Human   612 PTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLR-PWWQNES 675

  Fly   558 SRQFRQGLQCLQQQ---------MATGSKWIDEKLADFVALRLAYETFFG-VRDKREPRDPLLPQ 612
            ...||....|:::|         ...|.:.:.|.:||...|:.||..:.. :|...|.:......
Human   676 LAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVG 740

  Fly   613 FSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKM 675
            .:..||||:.|||.:|.   |.:|.|..|..:  .|:....||:.||:|..:|.|.|||...:.|
Human   741 LTNHQLFFVGFAQVWCS---VRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPM 802

  Fly   676 QASQRCRIW 684
            ...|.|.:|
Human   803 NPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	152/716 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	150/708 (21%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	150/708 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020