Protein Alignment Nepl5 and ECE2

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 724
• Identity: 154/724 - (21%)
• Similarity: 290/724 - (40%)
• Gaps: 135/724 - (18%)

  Fly    36 LAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRY-QGQMLPTDTLGLIDH 99
            :|.::...:|....|||:|||::||.| |::......|.| |......: |.|.:
Human   148 VAGKILESLDRGVSPCEDFYQFSCGGW-IRRNPLPDGRSR-WNTFNSLWDQNQAI---------- 200

  Fly   100 SVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLK------------------------PY 140
                 |:.||   ..::|.|.|...::.:.:|.||.:::                        |:
Human   201 -----LKHLL---ENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPW 257

  Fly   141 NLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLREE--VLPRWDDSRNYS 203
            :...::::|        .:|...:|...|..:......:....|.:.:.:.  .||    ||:|
Human   258 DQDNFMEVL--------KAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLP----SRDY- 309

  Fly   204 IYVNKPSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRL-----QELEDDEGPR 263
             |:|:.:.::........|.||.:.:|....:.....:||.:.|.:|..:     |..::::...
Human   310 -YLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYH 373

  Fly   264 EMQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLK 328
            :|.:..|.:..|.:.||.|:..:....||.....:::..:.||:.:|:|:....|..:.:|::
Human   374 KMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLI-- 436

  Fly   329 WLAFLKQQGPAD---------------------ISRGE-CVAALRRAMPLASSWLVGQQFSDPES 371
            |....|.....|                     :.|.: |::....|:..|...|..:...|.:|
Human   437 WNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQS 501

  Fly   372 ESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDVEQYHV 432
            :.....:...::..|.:.|.: .:.:........::|..|:...:||    .:.:|::||...:
Human   502 KEIAEGMISEIRTAFEEALGQ-LVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGY- 564

  Fly   433 RIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSP-----LYV 492
              ::|..||:.|.|                |:.||:....::......|.:..:.:|     .|:
Human   565 --EISEDSFFQNML----------------NLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYL 611

  Fly   493 RPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGA 557
            ..:|.::.|.|:||.|.:.||.........:|.|:.|||.|.||..|.:||..||:. |..:..:
Human   612 PTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLR-PWWQNES 675

  Fly   558 SRQFRQGLQCLQQQ---------MATGSKWIDEKLADFVALRLAYETFFG-VRDKREPRDPLLPQ 612
            ...||....|:::|         ...|.:.:.|.:||...|:.||..:.. :|...|.:......
Human   676 LAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVG 740

  Fly   613 FSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKM 675
            .:..||||:.|||.:|.   |.:|.|..|..:  .|:....||:.||:|..:|.|.|||...:.|
Human   741 LTNHQLFFVGFAQVWCS---VRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPM 802

  Fly   676 QASQRCRIW 684
            ...|.|.:|
Human   803 NPGQLCEVW 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	150/708 (21%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	150/708 (21%)