DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Ece1

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	184/776 - (23%)
Similarity:	308/776 - (39%)	Gaps:	172/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLSLVAWL-IFSLAWRT-TPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQ 63
            :|...|||.| ...:.:|| ||..| .|.|..||    ...:.:.||....||::|:.||||.|
  Rat    74 LLAAGLVACLAALGIQYRTRTPPVC-LTEACVSV----TSSILNSMDPTVDPCQDFFSYACGGW- 132

  Fly    64 IQQQ---EQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILE 125
            |:..   :.||    .|        |..     ..|.:|:     :.:::...|:|..|.|...:
  Rat   133 IKANPVPDGHS----RW--------GTF-----SNLWEHN-----QAIIKHLLENSTASASEAEK 175

  Fly   126 QMRLYYRSC---KRLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLH------ 181
            :.::|||:|   .|::....|..::|:.....  |...| .|..:.|.  .||..:..|
  Rat   176 KAQVYYRACMNETRIEELRAKPLMELIEKLGG--WNITG-PWAKDNFQ--DTLQVVTAHYRTSPF 235

  Fly   182 ----------GLNGVLLREEV----LPRWDDSRNYSIYVNKPSRQETQPMGEGAMIEL--LLDIG 230
                      ..|..:::.:.    ||    ||:|  |:||...::........|::|  ||. |
  Rat   236 FSVYVSADSKNSNSNVIQVDQSGLGLP----SRDY--YLNKTENEKVLTGYLNYMVQLGKLLG-G 293

  Fly   231 QTKRTANALARQVDDFERKLHRL---QELEDDEGPREMQLGY-------LDSYLPQLRWLSFMRQ 285
            ..:.:.....:|:.|||..|..:   ||...||     :|.|       |.:..|.:.||.|:..
  Rat   294 GDEDSIRPQMQQILDFETALANITIPQEKRRDE-----ELIYHKVTAAELQTLAPAINWLPFLNA 353

  Fly   286 VRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIM----LKWLAFLKQQ-GPADISRGE 345
            :....|::....:::.:..|||.:|.|:.|.....:.:|:|    .|..:||.|: ..||....|
  Rat   354 IFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFME 418

  Fly   346 ---------------CVAALRRAMPLA-SSWLVGQQFSDPESESYVSSLFQRLKVRFGQILA--- 391
                           ||:.....:..| ....|...|:: :|::..|.:...:|..|.:.|:
  Rat   419 VMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE-DSKNIASEIILEIKKAFEESLSTLK 482

  Fly   392 ---ENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLL 449
               |:..|.:       ::|..|:...:|:    ...:|::.|...:..:.
  Rat   483 WMDEDTRRSA-------KEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVP-------------- 526

  Fly   450 RQRVEANHDLLYINVTNFAN----STGSNLSYLSESWEASNSSPL---YVRP-RNLVLVPHGLLQ 506
                    ||.:.|...|.|    .|...|.......:.|.:.|:   |..| :|.::.|.|:||
  Rat   527 --------DLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQ 583

  Fly   507 LPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQ 571
            .|.:.|:.........:|.|:.|||.|.||..|.:||..||:. |..:..:...|:|..:|:.||
  Rat   584 APFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLR-PWWKNSSVEAFKQQTECMVQQ 647

  Fly   572 M---------ATGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLPQ--FSQRQLFFITFAQ 625
            .         ..|...:.|.:||...|:.||..:.. ..|:...:.:||.  .:..||||:.|||
  Rat   648 YNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQN-WVKKNGAEQILPTLGLTSNQLFFLGFAQ 711

  Fly   626 FFCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            .:|.   |.:|.|..|..:  .|:....||:.:|:|.:|||..|.|...:.|....:|.:|
  Rat   712 VWCS---VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	169/731 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	166/723 (23%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	171/742 (23%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	166/723 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920