DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and ece2b

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	748	Identity:	155/748 - (20%)
Similarity:	284/748 - (37%)	Gaps:	155/748 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHS 100
            :|.::...:|..|.||::|||||||.|         :|.......|.|:       .|...|...
Zfish   103 VASKIVEALDRSADPCQDFYQYACGGW---------VRKNPLPDGRSRW-------STFNSIWDQ 151

  Fly   101 VNRKLELLLRRRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQLLPPSNSTQWPSVGR 162
            ....|:.||   ...:|.|.|....:.:.||.||   :|::....:..:.|:.....  | ::..
Zfish   152 NQAVLKHLL---ENGTFNSSSEAERKTQSYYLSCLNEQRIEELGAQPLMDLITKIGG--W-NITE 210

  Fly   163 GWRPERF--------------DWITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSIYVNKPSRQE 213
            .|..|.|              .:.|....:.....|..:::.:....:..||:|  |:||.:.:.
Zfish   211 SWDKENFLDVLKIISGPYRAQPFFTVSVSVDPKNSNSNVIQVDQSGLFLPSRDY--YLNKTNEKV 273

  Fly   214 TQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPRE-----MQLGYLDSY 273
            .:...: .|:||.|.:|..|.:.....:|:.|||..|..:...:|:....|     :.:..|...
Zfish   274 LKAYLD-YMVELGLLLGGDKNSTRGQMQQILDFETALANITVPQDERRDEEKIYHKITIADLQVL 337

  Fly   274 LPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGP 338
            .|.:.||.::..|....||:....:::....|::.:|:|:.......:.:|::  |  .|.|:|.
Zfish   338 APAIEWLDYLNSVLSPLELNDTEPVVVYAKEYMQQVSELINKTDHSLLNNYMI--W--NLVQKGA 398

  Fly   339 ADISR------------------------GECVAALRRAMPLASSWLVGQQFSDPESE------- 372
            :.:.:                        ..|:......:..|...|..:...|.:|:
Zfish   399 SSLDQRFENAQDKLLESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGG 463

  Fly   373 -----------SYVSSLFQRLKVRFGQILAENRMRLSPPLVHI----------LQQKLRAVRLQM 416
                       |.|.:|...:..:...::.|.|......|..:          .:.|..|:...:
Zfish   464 AFLPSCGRNVNSTVHNLMFSVITQAEGMINEIRTAFKGALDDLKWMDEQTRQAAKDKADAIYDMI 528

  Fly   417 GF----FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSY 477
            ||    ..::|::||        ..|:              |...|..:.|:.||.|.:...::.
Zfish   529 GFPDFILDSKELDDV--------YDGY--------------EVTEDNFFQNMINFYNFSARVMAD 571

  Fly   478 L------SESWEAS--NSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHG 534
            .      .:.|..:  ..:..|:..:|.::.|.|:||.|.:.::.........:|.|:.|||.|.
Zfish   572 QLRKPPNRDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFYAQDHPKALNFGGIGVVMGHELTHA 636

  Fly   535 FDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMA---------TGSKWIDEKLADFVALR 590
            ||..|.:||..||:....:. .:...|:...:|:..|..         .|.:.:.|.:||...|:
Zfish   637 FDDQGREYDKDGNLRSWWQN-SSVEAFKNRTECMVDQYTQYTINGEHINGKQTLGENIADNGGLK 700

  Fly   591 LAYETF--FGVRDKREPRDPLLPQFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL--KHAADEL 651
            .||..:  :..::..|.|.|.: ..:..||||:.|||.:|.   |.:|.|..|..:  .|:..:.
Zfish   701 AAYHAYRSWVQKNGEEKRLPAV-NLTNDQLFFVGFAQVWCS---VRTPESAHEGLMTDPHSPPKY 761

  Fly   652 RVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            ||:.||:|..||:..|.|...:.|.:..||.:|
Zfish   762 RVIGTLSNSPEFAEHFQCPLGSSMNSGHRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	153/740 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	151/732 (21%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020