DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and MMEL1

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	788	Identity:	175/788 - (22%)
Similarity:	301/788 - (38%)	Gaps:	224/788 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QSVQE--------MLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQG 86
            |.|.|        :.|.::...||....||::|||:|||.|         ||.........||.
Human    83 QEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGW---------LRRHVIPETNSRYS- 137

  Fly    87 QMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKR---LKPYNLKKYLQL 148
                      |...:..:||::|:...|:|...|...:|:.|..||||..   ::....:..|.:
Human   138 ----------IFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDI 192

  Fly   149 LP-----PSNSTQW-PSVGRGWRPERFDWITTLGRLRLHGLNGVLLREEVLPR--WDDSRNYS-- 203
            |.     |....:| .:||..|..||          :|..:|....|..::..  |:|.:|.|
Human   193 LEVVGGWPVAMDRWNETVGLEWELER----------QLALMNSQFNRRVLIDLFIWNDDQNSSRH 247

  Fly   204 -IYVNK-----PSRQETQPMGEG-----AMIELLLDIGQTKRTANALAR----------QVDDFE 247
             ||:::     |||:.....|..     |.::.::.:....|....|.|          ||.:.|
Human   248 IIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELE 312

  Fly   248 RKL-----------------HR--LQELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRIDSELD 293
            .:|                 ||  |:||:...|            |....|..|::.|....::.
Human   313 TQLAKATVPQEERHDVIALYHRMGLEELQSQFG------------LKGFNWTLFIQTVLSSVKIK 365

  Fly   294 L--RSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGP------------------ 338
            |  ...:::..||||:.|.:::::.|..|:.:|::  |...|.:.|.
Human   366 LLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLV--WRLVLDRIGSLSQRFKDTRVNYRKALFG 428

  Fly   339 ---ADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQIL-------AEN 393
               .::...|||..:...|..|...|..::....:|:|.|..|..:::..|.:.|       .|:
Human   429 TMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEES 493

  Fly   394 RMRLSPPLVHILQQKLRAVRLQMG---FFQTEEIEDVEQYHVRIDLSGHSFYGNQLV-------- 447
            :.:        .|:|..::|.|:|   :...|....:::.:..::.|...::.|.|.
Human   494 KKK--------AQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQR 550

  Fly   448 ---LLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLPI 509
               .||::|:.|..::...|.|                      ..|...||.::.|.|:||.|.
Human   551 SLRKLREKVDPNLWIIGAAVVN----------------------AFYSPNRNQIVFPAGILQPPF 593

  Fly   510 WHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCL------ 568
            :.:..........:|.|:.||:.||||..|.::|..||:|...... :::.||:..:|:
Human   594 FSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNF-STQHFREQSECMIYQYGN 657

  Fly   569 ------QQQMATGSKWIDEKLADFVALRLAYETFF-----GVRDKREPRDPLLPQFSQRQLFFIT 622
                  .:|...|...:.|.:||...:|.||:.:.     |.:|::.|...|    :..|||||.
Human   658 YSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDL----THEQLFFIN 718

  Fly   623 FAQFFCG-----------RTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQ 676
            :||.:||           :|.|.||       ||:     ||:.:|.|...|:..|.|.:...|.
Human   719 YAQVWCGSYRPEFAIQSIKTDVHSP-------LKY-----RVLGSLQNLAAFADTFHCARGTPMH 771

  Fly   677 ASQRCRIW 684
            ..:|||:|
Human   772 PKERCRVW 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	170/766 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	166/758 (22%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	170/767 (22%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	166/756 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920