DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and mmel1

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	754	Identity:	170/754 - (22%)
Similarity:	306/754 - (40%)	Gaps:	164/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDT 93
            ||.|  ..|.:|...||....||:||||||||.|    .|:|.:.:                |.:
Zfish    78 PQCV--TAAARLLQNMDPSVDPCQNFYQYACGGW----IERHVIPE----------------TSS 120

  Fly    94 LGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKR---LKPYNLKKYLQLLPPSNST 155
            |..:.:.:..:||::|:...|...:.|....::.:..|.||..   ::..:.:..|:|:  .:..
Zfish   121 LHSVFNILRDELEIVLKGVLEMENKDDREAFKKAKTLYSSCMNEILIEQRDSQPLLRLI--DSIG 183

  Fly   156 QWPSVGRGWR---PERFDWITTLGRLRLHGLNGVLLREEVLPR--WDDSRN---YSIYVNKPS-- 210
            .||.....|.   .:.:....||.     .|||...::.||..  |.|.|:   |.|:|::|:
Zfish   184 DWPVASEVWNGTSEQTWSLEDTLA-----VLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALG 243

  Fly   211 -RQETQPMGEG-------AMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDD----EGPR 263
             ......:.:|       |.:|.::.:.:..|....|.:..:.....:.::.|||.|    ..|.
Zfish   244 MPSRDYYLSDGNYKKVREAYLEFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPA 308

  Fly   264 EMQLGYLDSY-------------LPQLRWLSFMRQVRIDSELDLRS--TLIIENIPYLRALSDLM 313
            |.:......|             |....|..:::.:.....:.::|  .::|...|||..||:::
Zfish   309 EERNDITVLYNKMTLREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVL 373

  Fly   314 ESESPDTVCSYIMLKWLAFLKQQGPADISR-----------------------GECVAALRRAMP 355
            ...|..|:.:|::  |:..:.:  .:.:||                       .:||..::..|.
Zfish   374 SKHSHRTLQNYLV--WMLIMDR--VSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNME 434

  Fly   356 LASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAE-------NRMRLSPPLVHILQQKLRAVR 413
            .|...|..::.....|:..|..|.::::..:.:.|.|       ::::        .::|..|:.
Zfish   435 NAVGALYVRETFSGNSKRMVGELIKKIQEAYVETLEELSWMDEQSKVK--------AREKAMAIS 491

  Fly   414 LQMGF---FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNL 475
            .|:|:   ...||.:.::|.:..::.|..:::.|.|..|....:..|..|...|.
Zfish   492 EQIGYPDHILEEENKKLDQEYAHLNFSEENYFENILENLAASAQKGHKKLREPVD---------- 546

  Fly   476 SYLSESW--EASNSSPLYVRPRNLVLVPHGLLQLPIW-HRNISALQQHAVMGFVLAHELAHGFDM 537
               .:.|  .|:..:..|...||.::.|.|:||.|.: .:.:.||....: |.|:.||:.||||.
Zfish   547 ---PDMWIIGAAVVNAFYSHNRNQIVFPAGILQPPFFSEKQLQALNFGGI-GMVIGHEITHGFDD 607

  Fly   538 LGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQM------------ATGSKWIDEKLADFVALR 590
            .|.::|..||:........|.| |....:|:.:|.            .:|...:.|.:||...:|
Zfish   608 HGRNFDKDGNMYNWWSNYSAER-FEDQSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVR 671

  Fly   591 LAYETF--FGVRDKREPRDPLLPQFSQRQLFFITFAQFFCG--------RTPVLSPRSQSEAHLK 645
            .||:.:  :..|:..|||.|.| ..:.:||||:.|||.:||        :|....|
Zfish   672 QAYKAYVKWVEREGEEPRLPGL-DMNHKQLFFLNFAQVWCGACRPEYAIQTIKTDP--------- 726

  Fly   646 HAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            |:..|.||:.:|.|||.||..|.|.:.|.|...::||:|
Zfish   727 HSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEEKCRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	164/739 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	160/731 (22%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	164/740 (22%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	160/731 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020