DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and PHEX

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	753	Identity:	175/753 - (23%)
Similarity:	308/753 - (40%)	Gaps:	157/753 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQ---QEQHSLRDRDWTRDRQRYQGQMLP 90
            |:.::  .|..:.|.::....||:||:::||..|....   ::..|.....|.|
Human    57 PECIE--AAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLR----------- 108

  Fly    91 TDTLGLIDHSVNRKLELLL-----RRRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQ 147
                    |:|:.||:.||     |||       |:..:::.::.|.||   |.::..:.|..|.
Human   109 --------HNVDLKLKELLEKSISRRR-------DTEAIQKAKILYSSCMNEKAIEKADAKPLLH 158

  Fly   148 LLPPSNSTQWP----SVG-RG-WRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSI-- 204
            :|..| ..:||    ::| .| |...:|..:.||...|....|.|.:|..|.|. |.:.|..|
Human   159 ILRHS-PFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPD-DKASNEHILK 221

  Fly   205 -------------YVNKPSRQETQPMGEGAMIELLLD----IGQTKRTANALARQVDDFERKLHR 252
                         |::..:..::.   ..|:.:.::|    :|.....|....:.|...|.|:..
Human   222 LDQATLSLAVREDYLDNSTEAKSY---RDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAE 283

  Fly   253 L---QELEDDEGP-REMQLGYLDSYLPQLRWLSFMRQVRIDSEL-----DLR-STLIIENIP-YL 306
            :   .|....|.. .:|.:..|.:.:||..||.::::| ||:.|     |:. |..::..:| |.
Human   284 IMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKV-IDTRLYPHLKDISPSENVVVRVPQYF 347

  Fly   307 RALSDLMESESPDTVCSYIM----------------LKWLAFLKQ-QGPADI--SRGECVAALRR 352
            :.|..::.||...|:.:|::                .:||.|.:. ||...:  ...:||..:..
Human   348 KDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIES 412

  Fly   353 AMPLASSWLVGQQFSD----PESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVR 413
            |:|    ::||:.|.|    .:.:..:..|.:.::..|..:|.:....:........::|.|||.
Human   413 ALP----YVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVL 473

  Fly   414 LQMGFFQTEEIEDVEQYHVRIDL-----SGHSFYGNQLVLLRQRVEANHDLLYI-----NVTNFA 468
            .::|:  .|.|  :...||..||     |...::||  ||..::..|..|..::     ....|.
Human   474 AKVGY--PEFI--MNDTHVNEDLKAIKFSEADYFGN--VLQTRKYLAQSDFFWLRKAVPKTEWFT 532

  Fly   469 NSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLP-IWHRNISALQQHAVMGFVLAHELA 532
            |.|..|..|.:.:              |.:..|.|.||.| .|.........:..:|.::.||..
Human   533 NPTTVNAFYSAST--------------NQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583

  Fly   533 HGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMAT-----------GSKWIDEKLADF 586
            ||||..|..||..|| :.|.....:..:|::..:|:..|.:.           |.:.:.|.:||.
Human   584 HGFDNNGRKYDKNGN-LDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADN 647

  Fly   587 VALRLAYETF-FGVRDKREP-RDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLKHA 647
            ..||.|:..: ..:.|:|:. .:||||  .|:..||||:::|...|......:.|.|.:.. .|:
Human   648 GGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIG-AHS 711

  Fly   648 ADELRVMQTLANFEEFSREFGCDKKAKM-QASQRCRIW 684
            ..:.||...::|||||.:.|.|...:.| :....||:|
Human   712 PPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	172/738 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	169/730 (23%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	169/730 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920