DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Nepl20

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	180/786 - (22%)
Similarity:	320/786 - (40%)	Gaps:	191/786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKLSLVAWL---IFSLAWRTTPTACRQTN-----APQSVQEMLAEQLQSYMDTKARPCENFYQYA 58
            :||..: |:   :.|:.....||:....|     ..:.:::..|.:::|:|:.|..||::||.::
  Fly     3 MKLFCI-WIASHVLSVLVLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFS 66

  Fly    59 CGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSI 123
            |||::               |.......::|.|.....:...:|||:..:|...:: |.::...|
  Fly    67 CGNYK---------------RINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHD-SHDTPEDI 115

  Fly   124 LEQMRLYYRSCKRLKPYN--LKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRL-RLHGLNG 185
              |::.:|.||.::|..|  ..:.|:.|.....|.....|..|:.:.|||:.|..|: ..:|:..
  Fly   116 --QVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMS 178

  Fly   186 VLLREEVLPRWDDSRNYSIYVNKPSRQETQPMGEGAM----------------IELLLD--IGQT 232
            : :...|...:.:::...||:|    |:..|:...:|                |:|:|:  :|..
  Fly   179 I-IGVGVATDFANNQKNIIYIN----QQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVK 238

  Fly   233 KRTANALARQVDDFE-------------RKLHRLQELEDDEGPREMQLGYLDSYLPQLRWLSFMR 284
            ...|...|:::.:||             ..|..|.||......||.....||:  .||.::|...
  Fly   239 DELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDT--DQLIFVSMGE 301

  Fly   285 QVRIDSELDLRSTLIIE-NIPYLRALSDLMESESPDTVCSYIMLK--WLAFLKQQGPADISRGEC 346
            ::         |..:.| |..|.:.|.:::|.....||.:|:.|:  |....|..|.|:.....|
  Fly   302 KI---------SDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEAC 357

  Fly   347 VAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQ----- 406
            |...:.........::.:::.:.:|...:.|::.:||..|.:.|      ||.|.:..::
  Fly   358 VDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETL------LSSPALDWIEPSTRS 416

  Fly   407 ---QKLRAVRLQMGFFQ----TEEIEDVEQYHVRIDLSGHSFYGN----QLVLLRQRVEANHD-- 458
               .||.|:.|::..:.    |||..|       ::|.......|    |::..:|..:..|.
  Fly   417 LAIAKLEAMTLEVNNYVKENFTEEFAD-------LNLQNTDCVENLRQVQMLQAKQMRQLYHQPA 474

  Fly   459 --LLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQ-LPIWHRNISALQQH 520
              |          ..|..|||          :|..:...|.:.||..||| ..||    |.:..:
  Fly   475 KPL----------EAGELLSY----------TPSNILLENSIKVPVALLQPFYIW----SDVYPN 515

  Fly   521 AVM----GFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMATGSKWI-- 579
            |||    .:::.|||.||||..|..:|..||.....:| .:|..|.:...|..:|.   .:::
  Fly   516 AVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDE-KSSSNFLKRRDCFTKQY---GRYVYD 576

  Fly   580 ----------DEKLADFVALRLAYETF-----------FGVRDKREPRDPLLPQFSQRQLFFITF 623
                      .|.:||...:||||..:           .|.:|..:...|.| :::.:|||||:|
  Fly   577 GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNL-RYTAKQLFFISF 640

  Fly   624 AQFFCGRTPVLSPRSQSEAHLK----------HAADELRVMQTLANFEEFSREFGCDKKAKMQAS 678
            ||.:|           ::.|.|          |...:.||:.||:||||||:||.|...:.|...
  Fly   641 AQSWC-----------NDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPI 694

  Fly   679 QRCRIW 684
            ::|.::
  Fly   695 EKCILY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	172/736 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	168/728 (23%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	170/727 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	168/727 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850