DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Nep7

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	164/753 - (21%)
Similarity:	280/753 - (37%)	Gaps:	201/753 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LQSYMDTKARPCENFYQYACGNW---QIQQQEQH---SLRDRDWTRDRQRYQGQMLPTDTLGLID 98
            ::|||:....||::||::|||||   :..:|..|   ::.|..:|                 |:|
  Fly    58 MKSYMNFSVDPCDDFYEFACGNWKNVKTPRQSPHRRSNILDISYT-----------------LMD 105

  Fly    99 HSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRL----KPYNLKKYLQLLPPSNSTQWPS 159
            .:.    :||.|.:...:....:.:|...| :|.||...    :|.....||.::.....  :|:
  Fly   106 VTE----QLLTRTKLAEALNVSAELLVAQR-FYNSCLAAELFPRPAADPAYLSVIRSLGG--FPA 163

  Fly   160 VGR-GWRPERFDWITTLGRLRLHGLNGVLLREEVLPR-------------WDDSRNYSIYVNKPS 210
            |.| .|....|.|......|..:|:.. |:.||:||:             :|...:.:...|..|
  Fly   164 VDRDAWNASSFSWFNMSAHLSNYGVRS-LIHEEILPQHPFNPYFKLPELGFDHVVHTAHVANTSS 227

  Fly   211 RQETQPMGEGAMIELLLDIGQTKRTANALARQV-----------DDFER---KLHRLQELEDDEG 261
            |  ...:.|..|...|.:...||...:|:...|           |.||.   |...|.|:|  |.
  Fly   228 R--AYQLNEHRMRGYLKEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDLLSEIE--EV 288

  Fly   262 PREMQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALS------------DLME 314
            ||   .|...||. ::.|                     ..|.:....|            |.:.
  Fly   289 PR---FGQWRSYY-EIAW---------------------NGIDFYNGSSGGEFCDFYYVELDKVC 328

  Fly   315 SESPDTVCSYIMLKWL----AFLKQQGPADISRGECVAALRRAMP-LASSWLVGQQFSDPESESY 374
            ::..:.|.:|:.:::|    ..||:....:..:..|:..::..:| |.:...:.:.|:| |..|.
  Fly   329 AKHTEAVANYLAMRFLYRMDDKLKEPKQPEDQKVNCLMIVQMTLPNLFNRLYMAEHFTD-EKHSE 392

  Fly   375 VSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQ--------MGFFQTEEIED--VEQ 429
            :|.:...::....|||..         |..|..:.||..|.        :|.::.||:.|  :.:
  Fly   393 ISDMVTEMRKAQRQILES---------VEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIRE 448

  Fly   430 YHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPL---- 490
            .:....:.|.  |...|:.||        :|...:..:|......|        ..::.||
  Fly   449 INNLTIVEGS--YAQSLINLR--------VLGTYLHRYAGLHADEL--------PKDTKPLTLLV 495

  Fly   491 -------YVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNI 548
                   |....|.|.|..|:|..|.:||:.....:...:|:::.|||.||||..|..:|:.|.:
  Fly   496 GMQVNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEV 560

  Fly   549 MGPVEEIGASRQ----FRQGLQCLQ-----------QQMATGSKWIDEKLADFVALRLAYETFFG 598
            ..     ..||:    |::..||..           .|...|::..||.:||...||.|   ..|
  Fly   561 RD-----WWSRKSEAVFQERAQCYVDYFNQYLIPEINQTIRGNETRDENIADAGGLRAA---LTG 617

  Fly   599 VRDKREP-------------RDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQ-SEAHLKHA 647
            .|:..:.             ::..:|  ..|..||||:.|||.:|..   ..|... .|....|.
  Fly   618 YRNHMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCAD---YEPEHYWEELTGAHT 679

  Fly   648 ADELRVMQTLANFEEFSREFGCDKKAKMQ-ASQRCRIW 684
            .|:.||:..::|.::|:..:.|...:.|. .::.||:|
  Fly   680 VDKYRVLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	163/749 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	158/741 (21%)
Nep7	NP_651603.1	PepO	60..717	CDD:226118	163/749 (22%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	158/741 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850