DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Nepl14

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	171/755 - (22%)
Similarity:	290/755 - (38%)	Gaps:	180/755 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNW--------QIQQQEQHSLRDRD 76
            |...|...:.|:|:...|:.:.|:::....||.:||.||||||        |:|||....|
  Fly    32 PPFQRIYQSEQTVRRSKAQDMGSHVNKSIDPCVDFYAYACGNWKSTLTPQQQLQQQTDREL---- 92

  Fly    77 WTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLKPYN 141
                             |.|::.:|.|:               ||.|:.|.:..::||...:.:.
  Fly    93 -----------------LLLVEEAVRRE---------------DSVIVRQAKELFKSCVSAQAHQ 125

  Fly   142 LKKYLQLLPP--SNSTQWPSV-GRGWRPERFD--WITTLGRLRL-HGLNGVLLREEVLPRWDDSR 200
            .::....|..  :.:..:|:| |..|.....|  |::.||.||| :|:: :|:...|...:.:..
  Fly   126 SQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMD-ILIGLRVGYNYGNVN 189

  Fly   201 NYSIYVNKPS-----------RQET-----QPMGEGAMIEL--LLDIGQTKRTANALARQVDDFE 247
            ..|:|:::||           |.:.     :|:......||  .|.:|..:  :..||..:..||
  Fly   190 ENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDE--SARLAADILSFE 252

  Fly   248 RKL-HRLQELEDDEGPREMQLGYLDSYLPQ-LRWLSFMRQVRIDSEL------DLRSTLIIENIP 304
            .:| ..::....:....|.|| ||.:|..: ||..|...::.:||.:      |:...:.:....
  Fly   253 HELCGGMKGGSFESWDAEEQL-YLANYTRKTLREFSNSIELDLDSYVRASFGQDIYKPVYMAAPE 316

  Fly   305 YLRALSDLMESESPDTVCSYIMLKWLAFLKQQGPAD----ISRGECVAALRRAMPLASSWLVGQQ 365
            |.|.|...:.:.:...|.:|||.:.::.|  ..|.|    :.:.||:...:..:|.|...|..:|
  Fly   317 YFRQLKRTVSAHNISLVANYIMYRAVSAL--NFPLDDRPQLRKRECLERTKELLPTALGELYARQ 379

  Fly   366 FSDPESESYVSSLFQRLKVRFGQI-----LAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIE 425
            |...:....:.:|:..||....|.     |.|...|:.       |:|||.::|||..::...|
  Fly   380 FGTEDGRIDLDNLYDTLKTALRQSLGAEWLVEGTQRVG-------QEKLRNLKLQMPTYERPVI- 436

  Fly   426 DVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPL 490
                  :::.|...:::.|    |||            :.....|..:|  .|.|.:..:.:.|:
  Fly   437 ------LKLQLERGNYWQN----LRQ------------LLGVVQSQRNN--RLFEEFLPAPTDPV 477

  Fly   491 YVRPRNLVLVP--------HGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFD-------MLGM 540
            ......:.|.|        ..|||.|.:........::|.:|..||.:|...||       :|..
  Fly   478 EAYEARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGLLER 542

  Fly   541 D---------YDAMGNIMGPVEEIGASRQFRQGLQCLQQQMATGSKWIDEKLADFVALRLAYETF 596
            |         |....|...           ||....|:..::..::.|.:..|..||.| ||.|:
  Fly   543 DNWDGQTAWQYHIRSNCFA-----------RQVDNYLRPNVSATTQLITDSAAINVAFR-AYLTW 595

  Fly   597 FGVRDKREPRDPL-------LP--QFSQRQLFFITFAQFFCGRTPVLSPRSQS--------EAHL 644
            .|.   :||.:..       ||  .:|...|||:.:||..|..... .||.:.        .|..
  Fly   596 LGF---QEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLEEA-RPRDEQGTPEGYLYSARQ 656

  Fly   645 KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            .|....|.|...|.|..||:.||.|...:.|..:.:|.|:
  Fly   657 NHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	165/731 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	163/723 (23%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	163/722 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850