DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Ece2

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	164/718 - (22%)
Similarity:	286/718 - (39%)	Gaps:	123/718 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRY-QGQMLPTDTLGLIDH 99
            :|.::...:|....||::|||::||.| |::....|.|.| |......: |.|.:
  Rat   249 VAGKILESLDRGVSPCQDFYQFSCGGW-IRRNPLPSGRSR-WNTFNSLWDQNQAI---------- 301

  Fly   100 SVNRKLELLLRRRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQLLPPSNSTQWPSVG 161
                 |:.||   ..|:|.|.|....:.|.:|.||   :|::....|....|:.....  |...|
  Rat   302 -----LKHLL---ENSTFNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGG--WNITG 356

  Fly   162 RGWRPERFDWI--TTLGRLRL------------HGLNGVLLREEVLPRWDDSRNYSIYVNKPSRQ 212
             .|..:.|..:  ...|..|.            ...|..:::.:....:..||:|  |:|:.:.:
  Rat   357 -PWDEDNFMEVLKAVAGTYRAAPFFTVYVGADSKSSNSNIIQVDQSGLFLPSRDY--YLNRTANE 418

  Fly   213 ETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRL-----QELEDDEGPREMQLGYLDS 272
            :........|:||.:.:|....:..|..:||.:.|.:|..:     |..::::...:|.:..|.:
  Rat   419 KVLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQT 483

  Fly   273 YLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQG 337
            ..|.:.||.|:..:....||.....:::....||:.:|:|:....|..:.:|::  |....|...
  Rat   484 LAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLI--WNLVQKTTS 546

  Fly   338 PADISRGE-----------------------CVAALRRAMPLASSWLVGQQFSDPESESYVSSLF 379
            ..| .|.|                       |::....|:..|...|..:...|.:|:.....:.
  Rat   547 SLD-QRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMI 610

  Fly   380 QRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDV-EQYHVRIDLSGH 439
            ..::..|.:.| ||.:.:........::|..|:...:||    .:..|::|| :.|.|..|
  Rat   611 SEIRAAFEETL-ENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPRELDDVYDGYEVSED---- 670

  Fly   440 SFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSP-----LYVRPRNLVL 499
            ||:.|.|                |:.||:....::......|.:..:.:|     .|:..:|.::
  Rat   671 SFFQNML----------------NLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIV 719

  Fly   500 VPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQG 564
            .|.|:||.|.:..|.........:|.|:.|||.|.||..|.:||..||:. |..:..:...|:..
  Rat   720 FPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLR-PWWQNESLTAFQNH 783

  Fly   565 LQCLQQQ---------MATGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLPQ--FSQRQL 618
            ..|:::|         ...|.:.:.|.:||...|:.||..:.....|.....| ||.  .:..||
  Rat   784 TACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQP-LPAVGLTNHQL 847

  Fly   619 FFITFAQFFCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRC 681
            ||:.|||.:|.   |.:|.|..|..:  .|:....||:.||:|..:|.|.|||...:.|...|.|
  Rat   848 FFVGFAQVWCS---VRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 909

  Fly   682 RIW 684
            .:|
  Rat   910 EVW 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	162/710 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	160/702 (23%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	160/706 (23%)
		M13	261..910	CDD:189000	160/702 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920