DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl5 and phex

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	750	Identity:	181/750 - (24%)
Similarity:	305/750 - (40%)	Gaps:	153/750 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDT 93
            |..|:  .|..:.|.||....||::|||||||.|         ||:.....|...|
Zfish    55 PHCVE--AAGSILSKMDQSVDPCDDFYQYACGGW---------LRENPIPEDSSSY--------- 99

  Fly    94 LGL---IDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQLLP--PSN 153
             |:   :..:|:.||:.||.:...|   .|...:::.::.|.||.......::....||.  ...
Zfish   100 -GIYPWLRQNVDLKLKELLEQPVRS---GDIEAVKKAKVLYASCMNESALEIEDANPLLKNLKQK 160

  Fly   154 STQWPSVGRG------WRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSIYVNK---- 208
            ..:||.:|..      |...:|:.:.||.::|......||:|..|.|   |.:|.:.|:.|
Zfish   161 EFRWPVLGDALGSSSRWVESQFNLLETLAQIRSQHSKSVLIRLFVAP---DDKNSNQYIIKLDQA 222

  Fly   209 ----PSRQ-------ETQPMGEGAMIELLLDI----GQTKRTANALARQVDDFERKLHRL----Q 254
                .||:       |.| |...|::.|::|:    |.:::.|.|..:.|.|||.||.::    :
Zfish   223 SLSLSSREDYITNTTEAQ-MYREALLRLMVDVSVMLGASEQAAEAQMKSVLDFEMKLAQIVIPYE 286

  Fly   255 ELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRIDSEL--DLR---STLIIENIP-YLRALSDLM 313
            ....:....:..|..|...:|...||.|:|.| ||:||  ||:   |..:|...| |.:.|..|:
Zfish   287 NRTSENMYNKYSLSKLQRTVPDFNWLGFVRAV-IDTELYPDLKISSSEQVIVRAPQYFKDLFKLI 350

  Fly   314 ESESPDTVCSYI----------------MLKWLAFLKQQGPADISRG---------ECVAALRRA 353
            .:....||.:|:                :.::|.|      |.::.|         :||..:...
Zfish   351 NATDTRTVANYVIWRSVFSRITTLSRRFLYRYLDF------ARVTTGTTSLTPRWDKCVNYVENT 409

  Fly   354 MPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGF 418
            :..|:..|...:....:.:..:..|...::..|..||.:....:..........|..||..::|:
Zfish   410 LIYAAGRLFVDKHFQEDKKHMMEELINGIRWAFIDILEKENEWMDEETKRKAIDKAHAVLPKVGY 474

  Fly   419 -----FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTN-----FANSTGS 473
                 ..|...||::    |:..:...::||  |:...:..|..|:.::..|.     |.|.|..
Zfish   475 PDFILNDTYINEDIK----RLAFTMTDYFGN--VMQTLKFIAQSDIGWLRKTVPRTEWFTNPTTV 533

  Fly   474 NLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLP-IWHRNISALQQHAVMGFVLAHELAHGFDM 537
            |..|.|.:              |.:..|.|.||.| .|..|......:..:|.::.|||.||||.
Zfish   534 NAFYSSST--------------NQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTHGFDN 584

  Fly   538 LGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQM-----------ATGSKWIDEKLADFVALRL 591
            .|..||..||:.........:| |.:..||:..|.           ..|.:.:.|.:||...:|.
Zfish   585 NGRKYDKDGNLDQWWSNSSINR-FTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGGIRE 648

  Fly   592 AYETF--FGVRDKREPRDPLLP--QFSQRQLFFITFAQFFCG--RTPVLSPRSQSEAHLKHAADE 650
            ::..:  :..:::....:||||  ..:..||||:::|...|.  |......:.||.|   |:..:
Zfish   649 SFRAYRRWVEKERGGVEEPLLPGVGLTHNQLFFLSYAHVRCNAYRPEAARDQIQSGA---HSPPK 710

  Fly   651 LRVMQTLANFEEFSREFGCDKKAKM-QASQRCRIW 684
            .||:..::|||||.:.|.|.:.:.| :.::.||:|
Zfish   711 YRVIGAMSNFEEFRKAFNCPETSIMNRGAESCRVW 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	177/735 (24%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	172/727 (24%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	177/739 (24%)
phex	NP_001307259.1	M13	72..743	CDD:189000	172/727 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920