DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Nepl4

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	164/723 - (22%)
Similarity:	289/723 - (39%)	Gaps:	169/723 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQ 87
            |..|     :.:...:.|.||:|::..|||:||.||||.|:.:....
  Fly    38 CNST-----INQQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSH------------------ 79

  Fly    88 MLPTDTLGLIDHSVNRKLELLLRR--RNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQLLP 150
               |....:.:..:||:.|.|..:  ||.|:.|....:..::..:|:||..|:..:|::|::||.
  Fly    80 ---TTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCIALEKPDLRRYIELLD 141

  Fly   151 PS-----NSTQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSIYVNKPS 210
            ..     |||.|..:           :..|||   :|.:|..::.||  ||.::.::.|::...:
  Fly   142 RDLLASLNSTHWMHL-----------LAALGR---YGYHGHYVQVEV--RWYNATHHMIFLLPHN 190

  Fly   211 RQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQE----LED-----------DE 260
            |.              |::..|:...:||::....:. .||:|||    ||.           |:
  Fly   191 RH--------------LNLSLTQDIYDALSQDGSSWP-PLHQLQEQFRSLEQNLVRLAKPHSADD 240

  Fly   261 GPREMQLGYLDSYLPQLRWLSFMRQ-----------VRID---------SELDLRSTLIIENIPY 305
            ..|...|..:.:.:|.|.|...:|.           .::|         ..|:...||::.....
  Fly   241 TFRNYSLDQIRTEVPGLHWDEALRTQLGRSVPGNHVFQVDDLDAIEGLVEYLNTVDTLLLNRYSL 305

  Fly   306 LRALSDLME-SESPDTVCSYIMLKWLAFLKQQGPADISRG-ECVAALRRAMPLASSWLVGQQFSD 368
            .|.||.|:| ..:|       :..|     :.|..  ||| .|:..:||::.|..:::..:.|..
  Fly   306 ARFLSHLLELPHNP-------LATW-----ESGQR--SRGRNCIRHMRRSVYLPMNYVYERSFYS 356

  Fly   369 PE---SESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIEDVEQY 430
            ..   .|..:.|:||:|:.:....:..|...||..||..||.|:..:|:.:|......   .||:
  Fly   357 RRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNV---TEQF 418

  Fly   431 HVRIDLS---GHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASN------ 486
            :...|..   |..||.|.|          :.|||. .|..|:...|:.....:.|.:.|
  Fly   419 YWDSDRRWSVGRDFYENHL----------NSLLYY-YTLVADLESSSDQEERDIWYSFNMHTPEF 472

  Fly   487 -----SSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMG 546
                 ::|.:....|::.||:..::.|.:..|......:..:...|.||:.|.||...:||||.|
  Fly   473 PDNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQG 537

  Fly   547 NIMGPVEEIGASRQFRQGLQCLQQQMATGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLP 611
            |:....:::|....:...:.||.    :.:..::|:.:|....|||.:|:.|         ..|.
  Fly   538 NLRNFSDQLGEVELYNGAVGCLN----SSAVMLNERTSDVSGSRLAMQTYGG---------DWLT 589

  Fly   612 QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQ 676
            :....:|:|:.||.||||          .|....|.:...|:...|....:|:..|.|...:.|.
  Fly   590 RSGNGRLYFLQFAHFFCG----------DEGDQYHDSGSQRLNYALGQVPQFAEVFRCHVGSGMT 644

  Fly   677 ASQRCRIW 684
            ::.:|..|
  Fly   645 SADQCPFW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	160/702 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	156/694 (22%)
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	158/694 (23%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	156/692 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0006719
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920