DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and goe

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001285350.1	Gene:	goe / 32660	FlyBaseID:	FBgn0027528	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	794	Identity:	150/794 - (18%)
Similarity:	273/794 - (34%)	Gaps:	266/794 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLSLVAWLIFSLAWRTTPTACRQTNAPQSVQEMLAE---QLQSYMDTKARPCENFYQYACGNW 62
            :|.|.::..|.|   |...|...|   ||..:.:...|   ||..:.:|...||...|::||||:
  Fly   139 LLLLIIILLLAF---WPEVPFYLR---APLCLDKECVESSRQLLLWANTSKSPCHETYEWACGNF 197

  Fly    63 --QIQQQEQHSLRDRDWTRDR-QRYQG--------QMLPTDTLGLIDHSVNRKLELLLRRRNESS 116
              .....|...::..:|..:. ..||.        .|||....|.::.:|:.    |.|...|:.
  Fly   198 ASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGSVESTVSS----LYRSCRETD 258

  Fly   117 F--ESDSSILEQMRL-------YYRSCKRLKPYNLKKYLQLLPPSNSTQWP----SVGRGW-RPE 167
            .  :|.|.:|.:..:       .:|...||:.:..|:.|.:|...:.. :|    :|..|: .|.
  Fly   259 VLDKSQSDLLLKRAINAVYGWQAFRDSNRLQSWEYKRVLVVLQAKHGI-FPYYRVTVENGFSNPH 322

  Fly   168 RFDWITTL--GRLRL-----HGLNGVLLREEVLPRWDDSRNYSIYVNKPSRQETQPMGEGAMIEL 225
              |::.||  |.|.|     :|.:.   .|||:      |.|.:.:.                :.
  Fly   323 --DYVITLDEGELGLPDKYFYGNDA---DEEVV------RGYKLLLR----------------DF 360

  Fly   226 LLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGP------REMQLGYLDSYLPQLRWLSFMR 284
            .:::|...|.|:..|..:..:||::  :..:||.:..      :.|:|..|....|.|..|..::
  Fly   361 AINMGIVSREADLFADDIFHYERRI--VNHIEDAKADANRPINKLMRLADLKIKAPSLPILESLQ 423

  Fly   285 QVRIDSELDLRSTLIIENIPYLRALSDLME------------------------------SESPD 319
            .:...:::...:.:::.:...:.|||.|:.                              :|:.|
  Fly   424 AIFPKTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHLSKEYRTLAETFD 488

  Fly   320 -------------TVCSYIMLKWLAF----LKQQGPADISRGECVAALRRAMPLASSWLVGQQFS 367
                         .:||.::..||.|    |:||.|.                        |||.
  Fly   489 HALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPR------------------------QQFE 529

  Fly   368 DPESESYVSSLFQ----RLKVRFGQILAENRMR--------LSPPLVHILQQKLRAVRLQMGFFQ 420
            ...|:|...:..|    .||:.|..:  .|:::        |.|.....:|:||..:|||.| ..
  Fly   530 TMTSKSRGLNKTQGNEELLKLMFFSL--RNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFG-IP 591

  Fly   421 TEEIED---VEQYHVRIDLSGHSF----------------------------------------- 441
            .|.::.   :.||:..:.|:...|
  Fly   592 DEVLQQPTYLAQYYNELILNNVFFVEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQAI 656

  Fly   442 -YGNQLVLL---RQRVEAN-HDLLYINVTNFA------------NSTGSNLSYLSESWEASNSSP 489
             |.|:|.:|   :..:.:| :|..|....|||            |.:...|.:.::|.:.|:::|
  Fly   657 AYSNKLNMLLVSKVLISSNYYDYRYPVAVNFARIGTDILEALIDNFSTFLLQFNTQSTDISDAAP 721

  Fly   490 --LYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPV 552
              .|.:| ::..:..|  |.|.....::.|..:|:..|.:....|.
  Fly   722 EIRYAQP-DVNCLAAG--QPPRLVHELNELSSNALKSFHVTLSAAR------------------- 764

  Fly   553 EEIGASRQFRQGLQCLQQQMATGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLPQFSQRQ 617
               .|:|.....:..:....|.....||:.           .|:..:...|..|.|.|..|::.:
  Fly   765 ---TAARALSNFVNAIDAGSAIQGSGIDQA-----------NTYEALGLTRRLRIPGLRSFNENE 815

  Fly   618 LFFITFAQFFCGRT 631
            ||.:::.|..|..|
  Fly   816 LFTLSYMQQHCSTT 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	138/750 (18%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	137/744 (18%)
goe	NP_001285350.1	GluZincin	184..>694	CDD:301352	107/570 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469644
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840