Protein Alignment Nepl5 and Mmel1

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001101467.2
• Gene: Mmel1 / 313755
• RGDID: 1309299
• Length: 774
• Species: Rattus norvegicus
• Alignment Length: 785
• Identity: 184/785 - (23%)
• Similarity: 305/785 - (38%)
• Gaps: 214/785 - (27%)

  Fly    18 TTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQ 82
            |||:..           :.|.::...||...:||:||||||||.|         ||.........
  Rat    86 TTPSCV-----------IAAARILQNMDQSKKPCDNFYQYACGGW---------LRHHVIPETNS 130

  Fly    83 RYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKR---LKPYNLKK 144
            ||.           :...:..:||::|:...|.|.......:|:.:..||||..   ::..:.:.
  Rat   131 RYS-----------VFDILRDELEVILKGVLEDSSVQHRPAVEKAKTLYRSCMNQSVIEKRDSEP 184

  Fly   145 YLQLLPPSNSTQWPSVGRGWRPERFDWITTLG-----RLRLHGLNGVLLREEVLPR--WDDSRNY 202
            .|.:|        ..:| ||......|..|:|     ..:|..||....|..::..  |:|.:|.
  Rat   185 LLNVL--------DMIG-GWPVAMDKWNETMGPKWELERQLAVLNSQFNRRVLIDLFIWNDDQNS 240

  Fly   203 S---IYVNKPS----------RQETQPMGEGAMIELLLDI-----------GQT----------- 232
            |   ||:::|:          ::::..:.| |.::.:..:           |:|
  Rat   241 SRHVIYIDQPTLGMPSREYYFKEDSHRVRE-AYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVL 304

  Fly   233 ---KRTANALARQV--DDFERKLHR--LQELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRIDS 290
               ...|||...|.  .|.....||  |:||::..|            |....|..|::.|....
  Rat   305 HLETHLANATVPQEKRHDVTALYHRMGLEELQERFG------------LKGFNWTLFIQNVLSSV 357

  Fly   291 ELDL--RSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGP--------------- 338
            :::|  ...:::..||||..|.::::.....|:.:|::  |...|.:.|.
  Rat   358 QVELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLV--WRLVLDRIGSLSQRFKEARVDYRKA 420

  Fly   339 ------ADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQIL------- 390
                  .::...|||:.:...|..|...|..::....:|:|.||.|.::::..|...|
  Rat   421 LYGTTMEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNLDELNWMD 485

  Fly   391 AENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEA 455
            .|::.:        .|:|...:|.|:|:  .:.|.:....|:..:.|..:|
  Rat   486 EESKKK--------AQEKALNIREQIGY--PDYILEDNNRHLDEEYSSLTF-------------- 526

  Fly   456 NHDLLYIN-VTNFANSTGSNLSYLSES-----W--EASNSSPLYVRPRNLVLVPHGLLQLPIWHR 512
            :.||.:.| :.|..|:...:|..|.|.     |  .|:..:..|...|||::.|.|:||.|.:.:
  Rat   527 SEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGILQPPFFSK 591

  Fly   513 NISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCL--------- 568
            :.........:|.|:.||:.||||..|.::|..||::.......| |.|||..||:
  Rat   592 DQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSA-RHFRQQSQCMIYQYSNFSW 655

  Fly   569 ---QQQMATGSKWIDEKLADFVALRLAYETFF-----GVRDKREPRDPLLPQFSQRQLFFITFAQ 625
               ..|...|...:.|.:||...:|.||:.:.     |.||:|.|...|    :..|||||.:||
  Rat   656 ELADNQNVNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQRLPGLNL----TYAQLFFINYAQ 716

  Fly   626 FFCG-----------RTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQ 679
            .:||           :|.|.||       ||:     ||:.:|.|...||..|.|.:.:.|....
  Rat   717 VWCGSYRPEFAIQSIKTDVHSP-------LKY-----RVLGSLQNLPGFSEAFHCPRGSPMHPMN 769

  Fly   680 RCRIW 684
            |||||
  Rat   770 RCRIW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	174/751 (23%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
		M13	106..772	CDD:341056	174/750 (23%)