DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Kel

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001178540.1	Gene:	Kel / 297025	RGDID:	1565470	Length:	713	Species:	Rattus norvegicus

Alignment Length:	796	Identity:	166/796 - (20%)
Similarity:	280/796 - (35%)	Gaps:	224/796 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLSLVAWLI-FSLAW-----RTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYAC 59
            :|.:.|...|| .|:.|     ...|..|......:.|...||...:|     |.||.:|:.:||
  Rat    30 LLAVLLCGLLIGCSMLWVYIFRNCGPWTCESPVCMELVNHYLASGNRS-----AAPCTDFFSFAC 89

  Fly    60 ----------------------------GNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGL 96
                                        |:|.::..|:.:.          ::....:.||.
  Rat    90 EKANGTSNSFQALAEENKSRLWKLLEAPGSWHLESGEEKAF----------QFYNSCMDTDA--- 141

  Fly    97 IDHSVNRKLELLLRR-------RNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQLLPPSNS 154
            |:.|....|..:::.       .|.:.|:.:.::...|..|...     |: .:.||...|....
  Rat   142 IEASGTGPLVQIIKELGGWNISGNWTFFDFNQNLRLLMSQYGHF-----PF-FRAYLHPHPAPPH 200

  Fly   155 TQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLRE--------EVLPRWDDSRNYSIYVNK--- 208
            |....:.   :|| ||               :||::        ::|      |.|..|:|:
  Rat   201 TPIIQID---QPE-FD---------------ILLQQDQEQKVYAQIL------REYVTYLNRLGT 240

  Fly   209 ---PSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGYL 270
               .:.||.|.....:::       .|.|....|..|          .|:...|:....:.:..|
  Rat   241 LLGSNPQEAQQHASWSIV-------FTSRLFQFLRPQ----------QQQQAQDKLFHVVTIDAL 288

  Fly   271 DSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMES---ESPDTVCSYIMLKWLAF 332
            ....|.:.|||.::.:.....|....||.:.::.|||.:|.|:|.   ...:.:.||::   |..
  Rat   289 QEMAPAIDWLSCLQAIFTPMSLSPSQTLQVHDLDYLRNMSQLVEEGLLNHSEIIQSYMI---LGL 350

  Fly   333 LKQQGPA-----DISRGECVAALRR-----AMPLASSWL-----VGQQFS------------DPE 370
            :....||     ..:|.|....||:     .:|....|:     .|..|.            .|.
  Rat   351 VDTLSPALATKFQEARRELTQKLRKLKERPPLPAYPRWMKCVEQTGSFFEPTLAALFVHEAFGPS 415

  Fly   371 SESYVSSLFQRLK----VRFGQ---ILAENRMRLSPPLVHILQQKL----RAVRLQMGFFQTEEI 424
            ..|....||..:|    ||..:   |..|.|......|.. ||.::    ||::.:|.   .:|.
  Rat   416 IRSAAMELFAEIKDAVIVRLKKLSWISEETRKEALNKLTQ-LQVEMGAPKRALKTEMA---KQEY 476

  Fly   425 EDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEAS--NS 487
            .|::        .|.||..:.|..:|       .|....|.:|..      .:....|:.|  :.
  Rat   477 SDIQ--------LGPSFLQSFLSCVR-------SLQGRKVRSFLQ------PFPYHRWQKSPWSV 520

  Fly   488 SPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPV 552
            |..|..|.::|:.|.||||.|.:|...........:|.::||:|.|.|    ..:...|..  |.
  Rat   521 SAYYSVPDHVVVFPAGLLQPPFFHPGYPRAVNFGAVGSIMAHKLLHIF----FQFLLPGGC--PA 579

  Fly   553 EEIGASRQFRQGLQCLQQQMA----------TGSKWIDEKLADFVALRLAYETFFGVRDKREPR- 606
            .:   :|..::.|.||:.:.|          .||..:.|..||...:.:|::.:   |.:...|
  Rat   580 CD---TRALQEALLCLEHRYAAFPLPSMSSFNGSHTLLENAADIGGVAIAFQAY---RKRITERT 638

  Fly   607 -DPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFG 668
             :..||  :.|..||||.::||..|.......|:.      .|:...|||...|:|..:|::.|.
  Rat   639 GELTLPNQELSPYQLFFRSYAQVMCRELISQDPQD------THSPPRLRVHGPLSNSPDFAKHFL 697

  Fly   669 CDKKAKMQASQRCRIW 684
            |...:.:..|.||::|
  Rat   698 CPSGSLLNPSTRCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	154/747 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	152/739 (21%)
Kel	NP_001178540.1	PepO	75..713	CDD:226118	154/749 (21%)
Kel	NP_001178540.1	M13	78..711	CDD:189000	152/739 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810