DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Mmel1

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	773	Identity:	182/773 - (23%)
Similarity:	302/773 - (39%)	Gaps:	189/773 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQ 82
            |||:..           :.|.::...||....|||||||||||.|         ||.........
Mouse    77 TTPSCV-----------IAAARILENMDQSRNPCENFYQYACGGW---------LRHHVIPETNS 121

  Fly    83 RYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKR---LKPYNLKK 144
            ||.           :...:..:||::|:...|.|.......:|:.:..||||..   ::..:.:.
Mouse   122 RYS-----------VFDILRDELEVILKGVLEDSTSQHRPAVEKAKTLYRSCMNQSVIEKRDSEP 175

  Fly   145 YLQLLPPSNSTQWPSVGRGWRPERFDWITTLG-----RLRLHGLNGVLLREEVLPR--WDDSRNY 202
            .|.:|        ..|| ||......|..|:|     ..:|..||....|..::..  |:|.:|.
Mouse   176 LLSVL--------KMVG-GWPVAMDKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNS 231

  Fly   203 S---IYVNKPS----------RQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQ 254
            |   ||:::|:          :::.......|.:|.:..:....|....|:::......::..:.
Mouse   232 SRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEFMTSVATMLRKDQNLSKESAMVREEMAEVL 296

  Fly   255 ELE----DDEGPREMQLGYLDSY-------------LPQLRWLSFMRQVRIDSELDL--RSTLII 300
            |||    :...|:|.:......|             |....|..|::.|....|::|  ...:::
Mouse   297 ELETHLANATVPQEKRHDVTALYHRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVV 361

  Fly   301 ENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGP---------------------ADISRG 344
            ..||||..|.|:::|.|..|:.:|::  |...|.:.|.                     .::...
Mouse   362 YGIPYLENLEDIIDSYSARTMQNYLV--WRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWR 424

  Fly   345 ECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQIL-------AENRMRLSPPLV 402
            |||:.:...|..|...|..::....:|:|.|..|.::::..|...|       .|::.:
Mouse   425 ECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEKIRSVFVDNLDELNWMDEESKKK------ 483

  Fly   403 HILQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYIN-VTN 466
              .|:|...:|.|:|:  .:.|.:....|:..:.|..:||              .||.:.| :.|
Mouse   484 --AQEKAMNIREQIGY--PDYILEDNNKHLDEEYSSLTFY--------------EDLYFENGLQN 530

  Fly   467 FANSTGSNLSYLSES-----W--EASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMG 524
            ..|:...:|..|.|.     |  .|:..:..|...||.::.|.|:||.|.:.::.........:|
Mouse   531 LKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIG 595

  Fly   525 FVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCL------------QQQMATGSK 577
            .|:.||:.||||..|.::|..||::.......| |.|:|..||:            ..|...|..
Mouse   596 MVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSA-RHFQQQSQCMIYQYGNFSWELADNQNVNGFS 659

  Fly   578 WIDEKLADFVALRLAYETFF-----GVRDKREPRDPLLPQFSQRQLFFITFAQFFCG-------- 629
            .:.|.:||...:|.||:.:.     |.:|:|.|...|    :..|||||.:||.:||
Mouse   660 TLGENIADNGGVRQAYKAYLRWLADGGKDQRLPGLNL----TYAQLFFINYAQVWCGSYRPEFAV 720

  Fly   630 ---RTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
               :|.|.||       ||:     ||:.:|.|...||..|.|.:.:.|...:|||||
Mouse   721 QSIKTDVHSP-------LKY-----RVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	176/747 (24%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	172/739 (23%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	176/748 (24%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	172/738 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12569
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.970