DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Phex

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	751	Identity:	174/751 - (23%)
Similarity:	308/751 - (41%)	Gaps:	153/751 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQ---QEQHSLRDRDWTRDRQRYQGQMLP 90
            |:.::  .|..:.|.::....|||||:::||..|....   ::..|.....|.|
  Rat    57 PECIE--AAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLR----------- 108

  Fly    91 TDTLGLIDHSVNRKLELLL-----RRRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQ 147
                    |:|:.||:.||     |||       |:..:::.::.|.||   |.::..:.|..|.
  Rat   109 --------HNVDLKLKALLEKSVSRRR-------DTEAVQKAKILYSSCMNEKAIEKADAKPLLH 158

  Fly   148 LLPPSNSTQWP----SVG-RG-WRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDDSRN----- 201
            :|..| ..:||    ::| .| |...:|..:.||...|....|.|.:|..|.|  ||..:
  Rat   159 ILRHS-PFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP--DDKASNEHIL 220

  Fly   202 ------YSIYVNKPSRQETQPMG--EGAMIELLLD----IGQTKRTANALARQVDDFERKLHRL- 253
                  .|:.|.:.....|....  ..|:.:.::|    :|.....|....:.|...|.|:..:
  Rat   221 KLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIM 285

  Fly   254 --QELEDDEGP-REMQLGYLDSYLPQLRWLSFMRQVRIDSEL-----DL-RSTLIIENIP-YLRA 308
              .|....|.. .:|.:..|.:.:||..||.::::| ||:.|     |: .|..::..:| |.:.
  Rat   286 IPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKV-IDTRLYPHLKDIGPSENVVVRVPQYFKD 349

  Fly   309 LSDLMESESPDTVCSYIM----------------LKWLAFLKQ-QGPADI--SRGECVAALRRAM 354
            |..::.:|...|:.:|::                .:||.|.:. ||...:  ...:||..:..|:
  Rat   350 LFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESAL 414

  Fly   355 PLASSWLVGQQFSD----PESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQ 415
            |    ::||:.|.:    .:.:..:..|.:.::..|..:|.:....:........|:|.|||..:
  Rat   415 P----YVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAK 475

  Fly   416 MGFFQ-----TEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYI-----NVTNFANS 470
            :|:.:     |...||::    .|..|...::||  ||..::..|..|..::     ....|.|.
  Rat   476 VGYPEFIMNDTYVNEDLK----AIKFSESDYFGN--VLQTRKYLAQSDFFWLRKAVPKTEWFTNP 534

  Fly   471 TGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLP-IWHRNISALQQHAVMGFVLAHELAHG 534
            |..|..|.:.:              |.:..|.|.||.| .|.........:..:|.::.||..||
  Rat   535 TTVNAFYSAST--------------NQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHG 585

  Fly   535 FDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMAT-----------GSKWIDEKLADFVA 588
            ||..|..||..|| :.|...:.:..:|::..:|:..|.:.           |.:.:.|.:||...
  Rat   586 FDNNGRKYDKNGN-LDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGG 649

  Fly   589 LRLAYETF-FGVRDKRE-PRDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLKHAAD 649
            ||.|:..: ..:.|:|: ..:||||  .|:..||||:::|...|......:.|.|.:.. .|:..
  Rat   650 LREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIG-AHSPP 713

  Fly   650 ELRVMQTLANFEEFSREFGCDKKAKM-QASQRCRIW 684
            :.||...::|||||.:.|.|...:.| :.:..||:|
  Rat   714 QFRVNGAISNFEEFQKAFNCPANSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	171/736 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	168/728 (23%)
Phex	NP_037136.2	M13	74..740	CDD:341056	167/721 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920