Protein Alignment Nepl5 and Kel

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_115929.3
• Gene: Kel / 23925
• MGIID: 1346053
• Length: 713
• Species: Mus musculus
• Alignment Length: 822
• Identity: 155/822 - (18%)
• Similarity: 278/822 - (33%)
• Gaps: 270/822 - (32%)

  Fly     3 KLSLVAWLIF-----------SLAW-----RTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPC 51
            :|:...|::.           |:.|     ...|..|......:.:...||...:|     ..||
Mouse    22 QLTRARWVLLAVLLCGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHYLASGNRS-----VAPC 81

  Fly    52 ENFYQYAC----------------------------GNWQIQQQEQHSLRDRDWTRDRQRYQGQM 88
            .:|:.:||                            |:|.:...|:.:.          ::....
Mouse    82 TDFFSFACEKANGTSDSFQALTEENKSRLWRLLEAPGSWHLGSGEEKAF----------QFYNSC 136

  Fly    89 LPTDT---------LGLIDH-------------SVNRKLELLLRRRNESSFESDSSILEQMRLYY 131
            :.||.         :.:|:.             ..|:.|.||:.:.....|         .|.|
Mouse   137 MDTDAIEASGSGPLIQIIEELGGWNITGNWTSLDFNQNLRLLMSQYGHFPF---------FRAY- 191

  Fly   132 RSCKRLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLREE----- 191
                 |:|:....:..::...            :|| ||               :||::|
Mouse   192 -----LRPHPAPPHTPIIQID------------QPE-FD---------------ILLQQEQEQKV 223

  Fly   192 ---VLPRWDDSRNYSIYVNK------PSRQETQPMGEGAMIELLLDIGQTKRTANAL-ARQVDDF 246
               :|      |.|..|:|:      .:.||.|.....:::       .|.|....| .:|....
Mouse   224 YAQIL------REYVTYLNRLGTLLGSNPQEAQQHASWSIV-------FTSRLFQFLRPQQQQQA 275

  Fly   247 ERKLHRLQELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSD 311
            :.||..:..:::           |....|.:.|||.::.:.....|:...||::.::.|||.:|.
Mouse   276 QDKLFHVVTIDE-----------LQEMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQ 329

  Fly   312 LMES---ESPDTVCSYIMLKWLAFLKQQGPA-----DISRGECVAALRR-----AMPLASSWL-- 361
            |:|.   ...:::.||::   |..:....||     ..:|.|.:..||:     .:|....|:
Mouse   330 LVEEGLLNHRESIQSYMI---LGLVDTLSPALDTKFQEARRELIQELRKLKERPPLPAYPRWMKC 391

  Fly   362 ----------------VGQQFSDPESESYVSSLFQRLK----VRFGQI--LAENRMRLSPPLVHI 404
                            |.:.|. |..:|....||..:|    :|..::  ::|...:.:
Mouse   392 VEQTGAFFEPTLAALFVREAFG-PSIQSAAMELFAEIKDAVIIRLKKLSWISEETQKEA------ 449

  Fly   405 LQQKLRAVRLQMGF--------FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLY 461
             ..||..::::||.        ..|:|..|::        .|.||..:.|..:|       .|..
Mouse   450 -LNKLAQLQVEMGAPKRAVKPDIATQEYNDIQ--------LGPSFLQSFLSCVR-------SLRA 498

  Fly   462 INVTNFANSTGSNLSYLSESWEAS--NSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMG 524
            .||.:|..      .:....|:.|  ..:..|....::|:.|.||||.|.:|............|
Mouse   499 RNVQSFLQ------PFPYHRWQKSPWEVNAYYSISDHMVVFPAGLLQPPFFHPGYPRAVNFGAAG 557

  Fly   525 FVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMA----------TGSKWI 579
            .::||||.|.|..|.:....      |..:   :...::.|.||::..|          .||..:
Mouse   558 SIMAHELLHIFYQLLLPGGC------PACD---THVLQEALLCLERHYAAFPLPSISSFNGSHTL 613

  Fly   580 DEKLADFVALRLAYETFFGVRDKREPRDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEA 642
            .|..||...:.:|::. :..|......:..||  ..|..||||.::||..|.......|:.
Mouse   614 LENAADIGGVAIAFQA-YSKRIVEHTGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQDPQD---- 673

  Fly   643 HLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
              .|:...|||...|:|..:|::.|.|.:...:..|.||::|
Mouse   674 --PHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNPSARCKLW 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	144/757 (19%)
Kel	NP_115929.3	M13	78..711	CDD:341056	144/757 (19%)