DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl5 and Ece1

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001356106.1	Gene:	Ece1 / 230857	MGIID:	1101357	Length:	769	Species:	Mus musculus

Alignment Length:	775	Identity:	182/775 - (23%)
Similarity:	307/775 - (39%)	Gaps:	170/775 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLSLVAWL-IFSLAWRT-TPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQ 63
            :|...|||.| ...:.::| ||..| .|.|..||    ...:.:.||....||::|:.||||.|
Mouse    74 LLAAGLVACLAALGIQYQTRTPPVC-LTEACVSV----TSSILNSMDPTVDPCQDFFSYACGGW- 132

  Fly    64 IQQQ---EQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILE 125
            |:..   :.||    .|        |..     ..|.:|:     :.:::...|::..|.|....
Mouse   133 IKANPVPDGHS----RW--------GTF-----SNLWEHN-----QAVIKHLLENATASVSEAER 175

  Fly   126 QMRLYYRSC---KRLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLH------ 181
            :.::|||:|   .|::....|..::|:.....  |...| .|..:.|.  .||..:..|
Mouse   176 KAQVYYRACMNETRIEELRAKPLMELIEKLGG--WNITG-PWAKDNFQ--DTLQVVTAHYRTSPF 235

  Fly   182 ----------GLNGVLLREEV----LPRWDDSRNYSIYVNKPSRQETQPMGEGAMIEL--LLDIG 230
                      ..|..:::.:.    ||    ||:|  |:||...::........|::|  ||. |
Mouse   236 FSVYVSADSKNSNSNVIQVDQSGLGLP----SRDY--YLNKTENEKVLTGYLNYMVQLGKLLG-G 293

  Fly   231 QTKRTANALARQVDDFERKLHRL---QELEDDEGPREMQLGY-------LDSYLPQLRWLSFMRQ 285
            ..:.......:|:.|||..|..:   ||...||     :|.|       |.:..|.:.||.|:..
Mouse   294 GDEDAIRPQMQQILDFETALANITIPQEKRRDE-----ELIYHKVTAAELQTLAPAINWLPFLNT 353

  Fly   286 VRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIM----LKWLAFLKQQ-GPAD----- 340
            :....|::....:::.:..|||.:|.|:.:.....:.:|:|    .|..:||.|: ..||
Mouse   354 IFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFME 418

  Fly   341 ---------ISRGE-CVAALRRAMPLA-SSWLVGQQFSDPESESYVSSLFQRLKVRFGQILA--- 391
                     |.|.: ||:.....:..| ....|...|:: :|::..|.:...:|..|.:.|:
Mouse   419 VMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAE-DSKNIASEIIMEIKKAFEESLSTLK 482

  Fly   392 --ENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLR 450
              :...|.|      .::|..|:...:|:    ...:|::.|...:..:.
Mouse   483 WMDEETRRS------AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVP--------------- 526

  Fly   451 QRVEANHDLLYINVTNFAN----STGSNLSYLSESWEASNSSPL---YVRP-RNLVLVPHGLLQL 507
                   ||.:.|...|.|    .|...|.......:.|.:.|:   |..| :|.::.|.|:||.
Mouse   527 -------DLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQA 584

  Fly   508 PIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQM 572
            |.:.|:.........:|.|:.|||.|.||..|.:||..||:. |..:..:...|:|..:|:.||.
Mouse   585 PFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLR-PWWKNSSVEAFKQQTECMVQQY 648

  Fly   573 A---------TGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLPQ--FSQRQLFFITFAQF 626
            :         .|...:.|.:||...|:.||..:.. ..|:...:..||.  .:..||||:.|||.
Mouse   649 SNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQN-WVKKNGAEQTLPTLGLTSNQLFFLGFAQV 712

  Fly   627 FCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            :|.   |.:|.|..|..:  .|:....||:.:|:|.:|||..|.|...:.|....:|.:|
Mouse   713 WCS---VRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	168/730 (23%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	165/722 (23%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	165/722 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920