Protein Alignment Nepl5 and nep-2

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 784
• Identity: 155/784 - (19%)
• Similarity: 299/784 - (38%)
• Gaps: 184/784 - (23%)

  Fly     4 LSLVAWLIFSLAWRTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQE 68
            |.|.|.:.|.:.::.:...|......::...:|     |.|::...||::||::|||.|
 Worm    34 LVLGAAIYFYINYKDSSDVCLSPGCIKTASVIL-----SSMNSSVDPCDDFYEFACGQW------ 87

  Fly    69 QHSLRDRDWTRDRQRYQGQMLPTDTLGLID-HSVNRKLELLLRR---RNESSFESDSSILEQMRL 129
                           .:|..:|.|...:.: .::.:.||..|:.   .|:..::.::|.:.:.:.
 Worm    88 ---------------IKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETSAVGKAKY 137

  Fly   130 YYRSCKRLKPYNLKKYLQLLPPSNST---------QWPSVGRGWRPE---RFDWITTLGRLRLHG 182
            :|..|....        ::|....:|         .|||:|...:|:   ...:...:.:.:...
 Worm   138 FYNLCLNES--------EILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADS 194

  Fly   183 LNGVLLREEVLPRWDDSRNYSIYVNKP-----------SRQETQPMGEGAMIE---LLLDIGQTK 233
                |.:..|.|...:|:.:.:.:::|           :.:..:.|....:|.   :|||..:|:
 Worm   195 ----LFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTR 255

  Fly   234 RTANALARQVDDFERKL----------HRLQELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRI 288
            .|.:  |:::.|||..|          |.:.||.     .::.||.:...||...|..|..::..
 Worm   256 ATLD--AKEIIDFETALANITMADEHRHDIAELY-----TKITLGEMRRSLPHFNWPLFFNRMFK 313

  Fly   289 DSE--------LDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQ---------- 335
            |..        .|..:.:::....:||.|..|:.......:.:|  |:|..|.|.
 Worm   314 DLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNY--LEWCWFFKTMLRDLPDPFA 376

  Fly   336 ------------QGPADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQ 388
                        .....:....||..:...||:|:|.:..:...|.|::..|..:...:...|..
 Worm   377 LTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIMESFVD 441

  Fly   389 ILAENRMRLSPPLVHILQQKLRAVRLQMGF-------------FQTEEIEDVEQYHVRIDLSGHS 440
            :|..... |:.......:||:..::.::|:             ::|.::.....|..:.     |
 Worm   442 LLLSEDW-LTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKF-----S 500

  Fly   441 FYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNS--SPLYVRPRNLVLVPHG 503
            ||......:.:|:....|                    .|.|.|..:  :..|....|.::.|.|
 Worm   501 FYEQYQRDVLERITEAVD--------------------RERWVAGAALVNAFYSPNTNEIIFPAG 545

  Fly   504 LLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCL 568
            :||...:.::..:......:|.|:.||:.||||..|..||.:|||....:....|: |....||:
 Worm   546 ILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISK-FEHKAQCI 609

  Fly   569 QQQMAT-----------GSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLP--QFSQRQLFF 620
            ::|.::           |.....|.:||...|:.||.. :...:||..|.|.||  ..:..||||
 Worm   610 EKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRA-YKKYEKRHSRPPRLPGVNLTHDQLFF 673

  Fly   621 ITFAQFFCGRTPVLSPRSQSEAHLK-----HAADELRVMQTLANFEEFSREFGCDKKAKMQASQR 680
            :.:||.:||      ..:..||..|     |:...:||...|:|..:|::.:.|:..::|...::
 Worm   674 LNYAQIWCG------TMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREK 732

  Fly   681 CRIW 684
            ||:|
 Worm   733 CRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	144/736 (20%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	144/736 (20%)