DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-18

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	149/789 - (18%)
Similarity:	277/789 - (35%)	Gaps:	194/789 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKLSLVAWLIFSLAWRTTPTACRQTNAPQSVQE---------MLAEQLQSYMDTKARPCENFYQY 57
            :.|.:..|   :..|   |:.  .:|||....|         :|| .:::|.:....|||:|:::
Worm     1 MALMIALW---ASLW---PSG--SSNAPNGSPETCWSKECVGVLA-MIKNYQNASVDPCEDFFEH 56

  Fly    58 ACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLR----RRNESSFE 118
            .||.:     .:|.:.|..|                 |.:.:.     :||.:    .|..:.|.
Worm    57 TCGRY-----SEHVMDDNSW-----------------GYVQYK-----QLLYQVFAIARKTNKFN 94

  Fly   119 SDSSILEQMRLYYRSCKRLKPYNLKKYLQLLPPSNSTQ----WPSVGRGWRPERFDWITTLGRLR 179
            |..:  ||:|::.:||...|..:...:..|   .|..:    :|.:...|..|:||....|.:..
Worm    95 SKPN--EQLRIFTKSCLDRKEMDEDTFQDL---RNDIEERGGFPMIDPNWNEEKFDLSDMLAKYL 154

  Fly   180 LHGLN--GVLLREEVL----------------PRWDDSRNYSIYVNKPS---------RQETQPM 217
            ....|  |.|..|...                |.|..:....|.:.|.|         :.|.:.:
Worm   155 SINRNRMGFLSVEPYAAIEGNKSVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENREL 219

  Fly   218 GEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGYLDSYLPQLRWLSF 282
            .|....:...::.|.:...:.||.         :|...|::|...:...|..|...:|::.|:..
Worm   220 NETIYDKEFAELVQLEANFSTLAD---------YRNLALDNDNMSKSRNLTDLVKMIPEIDWIKI 275

  Fly   283 MRQVRIDSELDLRSTLIIENI------PYL----RALSDLMESESPDTVCSYIMLKWLA-----F 332
            ::.:......:.....::|.:      .|.    |.|:.:........:.:|::::.|.     |
Worm   276 LKALARHGTSEEDEEKLLERVTVHGAGEYFFGENRELARIATETPKSALANYLVVRQLIDVALYF 340

  Fly   333 LKQQGPAD-------ISRGECVAALRRAMPLASS--WLVGQQFSDPESESYVSSLFQRLKVRFGQ 388
            ..:..|..       ..:..|...:....|:.|.  ::...||. .|:...:..:|.::|..:.|
Worm   341 YDKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFK-IENLKVIEEMFVKIKAEYEQ 404

  Fly   389 ILAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEE--------------IEDVEQYHVRIDLSGH 439
            |..||.. |...:...|.:||.|:..:.|..|..|              ::....:.|.:.:..|
Worm   405 IFTENEY-LELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMWRH 468

  Fly   440 SFYGNQLVLLRQRVEANHDLLYINVTNFA---------NSTGSNLSYLSESWEASNSSPLYVRPR 495
              :..|||   :.:..:..|..:|:..|.         |....||.||:..|..::.      |.
Worm   469 --WSEQLV---EHIVHDTPLDPVNLKMFGTHAAYQPYPNHFYINLPYLTYPWMDADF------PA 522

  Fly   496 NLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGP--VEEIGAS 558
            |                     ..:..:|:|:.||:.|.||......|..|.....  .|...::
Worm   523 N---------------------TNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSN 566

  Fly   559 RQFRQGLQCLQQQMA-----------TGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLPQ 612
            .::....:||:.|.:           .|:....|...|.:.:|.|:..|..|:.:...|.|.| :
Worm   567 TEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEKVKKEDRFRLPGL-E 630

  Fly   613 FSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKM 675
            .|:.||||..:|...|   .|.:|.......|  :|..:..||...:.|..||:..|.|.|.:.|
Worm   631 MSEEQLFFYNYAFRQC---DVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPM 692

  Fly   676 QASQRCRIW 684
            ....:|:::
Worm   693 NPEMKCKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	139/738 (19%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	137/730 (19%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	137/728 (19%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	137/730 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880