Protein Alignment Nepl5 and Phex

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 751
• Identity: 174/751 - (23%)
• Similarity: 309/751 - (41%)
• Gaps: 153/751 - (20%)

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQ---QEQHSLRDRDWTRDRQRYQGQMLP 90
            |:.::  .|..:.|.::....|||||:::||..|....   ::..|.....|.|
Mouse    57 PECIE--AAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLR----------- 108

  Fly    91 TDTLGLIDHSVNRKLELLL-----RRRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQ 147
                    |:|:.||:.||     |||       |:..:::.::.|.||   |.::..:.|..|.
Mouse   109 --------HNVDLKLKALLEKSVSRRR-------DTEAVQKAKILYSSCMNEKAIEKADAKPLLH 158

  Fly   148 LLPPSNSTQWP----SVG-RG-WRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDDSRN----- 201
            :|..| ..:||    ::| .| |...:|..:.||...|....|.|.:|..|.|  ||..:
Mouse   159 ILRHS-PFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP--DDKASNEHIL 220

  Fly   202 ------YSIYVNKPSRQETQPMG--EGAMIELLLD----IGQTKRTANALARQVDDFERKLHRL- 253
                  .|:.|.:.....|....  ..|:.:.::|    :|.....|....:.|...|.|:..:
Mouse   221 KLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIM 285

  Fly   254 --QELEDDEGP-REMQLGYLDSYLPQLRWLSFMRQVRIDSEL-----DL-RSTLIIENIP-YLRA 308
              .|....|.. .:|.:..|.:.:||..||.::::| ||:.|     |: .|..::..:| |.:.
Mouse   286 IPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKV-IDTRLYPHLKDIGPSENVVVRVPQYFKD 349

  Fly   309 LSDLMESESPDTVCSYIM----------------LKWLAFLKQ-QGPADI--SRGECVAALRRAM 354
            |..::.:|...|:.:|::                .:||.|.:. ||...:  ...:||..:..|:
Mouse   350 LFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESAL 414

  Fly   355 PLASSWLVGQQFSD----PESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQ 415
            |    ::||:.|.:    .:.:..:..|.:.::..|..:|.:....:........|:|.|||..:
Mouse   415 P----YVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAK 475

  Fly   416 MGFFQ-----TEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYI-----NVTNFANS 470
            :|:.:     |...||::    .|..|...::||  ||..::..|..|..::     ....|.|.
Mouse   476 VGYPEFIMNDTYVNEDLK----AIKFSESDYFGN--VLQTRKYLAQSDFFWLRKAVPKTEWFTNP 534

  Fly   471 TGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLP-IWHRNISALQQHAVMGFVLAHELAHG 534
            |..|..|.:.:              |.:..|.|.||.| .|.........:..:|.::.||..||
Mouse   535 TTVNAFYSAST--------------NQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHG 585

  Fly   535 FDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMAT-----------GSKWIDEKLADFVA 588
            ||..|..||..|| :.|...:.:..:|::..:|:..|.:.           |.:.:.|.:||...
Mouse   586 FDNNGRKYDKNGN-LDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGG 649

  Fly   589 LRLAYETF-FGVRDKRE-PRDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLKHAAD 649
            ||.|:..: ..:.|:|: ..:||||  .|:..||||:::|...|......:.|.|.:.. .|:..
Mouse   650 LREAFRAYRKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIG-AHSPP 713

  Fly   650 ELRVMQTLANFEEFSREFGCDKKAKM-QASQRCRIW 684
            :.||...::|||||.:.|.|.:.:.| :.:..||:|
Mouse   714 QFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	168/728 (23%)
Phex	NP_035207.1	M13	74..740	CDD:341056	167/721 (23%)