Protein Alignment Nepl5 and nep-4

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_509156.2
• Gene: nep-4 / 183746
• WormBaseID: WBGene00016896
• Length: 437
• Species: Caenorhabditis elegans
• Alignment Length: 716
• Identity: 118/716 - (16%)
• Similarity: 206/716 - (28%)
• Gaps: 329/716 - (45%)

  Fly     9 WLIFSLAWRTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQ---QQEQH 70
            |||....:..|      .||.:...:.:...|:..:|.|:.||::||::||....|:   :....
 Worm     2 WLIILFCFLPT------QNAYEHPFDFIENALEKIVDWKSDPCDDFYRHACPVGSIEDIIKVSMQ 60

  Fly    71 SLRD---RDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYR 132
            .|:|   ..|.:..||.:|::          :::|                           :.|
 Worm    61 PLKDALNHSWKQKGQRNEGKV----------YNIN---------------------------FRR 88

  Fly   133 S-------CKRLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLRE 190
            |       ||.|..|...:|                      ||             :|.|...:
 Worm    89 SHICCHFFCKLLFIYYDYQY----------------------RF-------------INYVTFYD 118

  Fly   191 EVL-PRWDDSRNYSIYVNKPSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQ 254
            .:| |.:     |.:..|                                   |.|...::|  |
 Worm   119 GMLQPLY-----YHVEAN-----------------------------------VTDGINEIH--Q 141

  Fly   255 ELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPD 319
            .:||     .::||.:        ||.             ::..:|.|     .|::.|::.:..
 Worm   142 MMED-----MVELGNI--------WLE-------------KTPWVINN-----NLTEEMKNITNA 175

  Fly   320 TVCSYIMLKWLAFL-KQQGPADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLK 383
            ......:.|:..|: ....|.:.....||:                :|...::.: :..||...|
 Worm   176 IKMPVSLTKYTNFIYNLLSPIETDFLNCVS----------------EFEGIQNNT-LFCLFYSAK 223

  Fly   384 VRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHSFYGNQLVL 448
            :                          .||.:..:|              ||.:|::..|.
 Worm   224 I--------------------------FVRTRGSYF--------------IDDNGYNAEGT---- 244

  Fly   449 LRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLPIWHRN 513
                       :|....|:.::|..|       |.||.
 Worm   245 -----------IYFGFPNYYHTTYGN-------WRASK--------------------------- 264

  Fly   514 ISALQQHAVMGFV---LAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMA-- 573
                     :|:.   :.||:.|.|....::.|.:.....|.|:            |:|.|..
 Worm   265 ---------LGYTGTRVGHEIGHTFIEHSINPDGLPYFSKPAED------------CVQNQYLKT 308

  Fly   574 --------------TGSKWIDEKLADFVALRLAYETFFGVRD----KREPRDPLLPQFSQRQLFF 620
                          |.....|:..||...|:|||...  .||    .||..|.|  :.:..||.|
 Worm   309 CNEYYEGEVPDACNTSDYTFDDNGADVFGLQLAYAIL--ERDLSDQLREQADGL--KITNEQLLF 369

  Fly   621 ITFAQFFCGRTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGC--DKKAKMQASQRCRI 683
            .:||..||..:   ...:...:|..|   .:|: ..:|....|.:.|.|  |.:....|:::|.|
 Worm   370 YSFAYRFCRGS---KSNTTDGSHSHH---NVRI-NAVAQMPGFQQAFNCASDSRMMKSATKQCVI 427

  Fly   684 W 684
            :
 Worm   428 Y 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	107/673 (16%)
nep-4	NP_509156.2	GluZincin	250..425	CDD:472708	47/240 (20%)