Protein Alignment Nepl5 and nep-21

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 771
• Identity: 161/771 - (20%)
• Similarity: 274/771 - (35%)
• Gaps: 213/771 - (27%)

  Fly    36 LAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTD-----TLG 95
            |||.|.|    |..|||:||::||||:.:.:.                     ||.:     |:.
 Worm   185 LAENLNS----KINPCEDFYEFACGNYGLNKN---------------------LPANKPLRHTIS 224

  Fly    96 LIDHSVNRKLELLLR---RRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQLLPPSNS 154
            .:...:|::::.:|:   ..||..::      :..:.||:.|   :.|:...::....:......
 Worm   225 DVQSRLNKQVKSMLQSPISANEKPWD------KVAKGYYQKCLDEEELESTGVEAMRDIAKRIGG 283

  Fly   155 TQWPSV-GRGWRPERFDWITTLGR-LRLHGLNGVLLREEVL---------------PRWDDSRNY 202
              ||:: |..|:.....|...:.. |.|.|:|.|:|...|.               |:|.....|
 Worm   284 --WPTLEGDKWQEWSHSWEEQIALVLNLTGVNAVILEMAVTHDPSNSSRSVIELDQPKWGAGSRY 346

  Fly   203 SIYVNKPSRQETQPMGEGAMIELLLDIGQ-TKRTANALARQVDDFERKLHRLQELE--------D 258
                         |...||...:|.:... .|.||.||.......|::::...|.|        |
 Worm   347 -------------PYLSGANDPMLRNYTTLMKMTAVALGADPAIAEKEMNEAMEFELKLVNFSAD 398

  Fly   259 D-------EGPREMQLGYLDSYLPQLRWLSFMRQVRID-SELDLRSTLIIENIPYLRALSDLMES 315
            |       .|....:|..|.|..|.:.:..:::.|..: ..|....|:|:..|.|...:..:::|
 Worm   399 DMVRRDPERGNNRFELWQLKSVFPFINFEKYLKTVFKELVALSPNHTVIVREIDYFVGIQHVLQS 463

  Fly   316 ESPDTVCSYIMLKWLAFLKQQGPADISRGECVAALRRAMPLASSWLVGQQFS-DPESESYVSSLF 379
            .....:.:||  .|.  |.|.||                       .|..|| .|.........|
 Worm   464 TPKRVLANYI--SWR--LVQGGP-----------------------TGDYFSFSPFLPPSAREPF 501

  Fly   380 QRLKVRFGQILAENRMRLSPP--------LVHILQQKLRAVRLQM-GFFQTEEI----------- 424
            .:.|..      :..|..|||        .:.::...:...||.: .||:.|..
 Worm   502 YQFKAN------QTGMFNSPPPDRWEDCVTLSVIMMDMPVGRLFVENFFEKERAMKKMTELTSYL 560

  Fly   425 --EDVEQYHV-----------RIDLSGHSFY--GNQLVLLRQR-VEAN------------HDLLY 461
              |.::|.||           .|..:....|  |..:||.... :|.|            |..:.
 Worm   561 KNEFIKQLHVLDWMDEITRRRAISKANMIEYKSGFPMVLFNDTWMEKNWGMIIKPREYLLHLTIR 625

  Fly   462 INVTNFANSTGSNLSYLSESWEASN--SSP----LYVRPRNLVLV-PHGLLQLPIWHRNISALQQ 519
            :.:..|.    ..|..|.:..:.|.  .||    .|..|.|..:: |.|::|.|.....:.....
 Worm   626 VKLVRFT----EELLRLDQPLDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYIT 686

  Fly   520 HAVMGFVLAHELAHGFDMLGMDYDAMGNIM----GPVEEIGASRQFRQGLQCLQQQM-------- 572
            :.::|.|:.||::|.||..|..||.|||:.    ...||     :|.:..:|..:|.
 Worm   687 YGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAETEE-----KFIEKTRCFVRQYENVHVVEA 746

  Fly   573 ---ATGSKWIDEKLADFVALRLAYETFFGVRDK----REPRDPLLPQFSQRQLFFITFAQFFCGR 630
               ..|...:.|.:||...::.|:..:...:..    .||..|....|:.:|:||:.:|..:|.
 Worm   747 DIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCS- 810

  Fly   631 TPVLSPRSQSEAHLK--HAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
              ::.|:...:..|.  ||..:.|.|..|.|..||::.|.|...:.|...::|::|
 Worm   811 --LVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	153/755 (20%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	153/755 (20%)