DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-16

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001023203.2	Gene:	nep-16 / 177541	WormBaseID:	WBGene00018472	Length:	868	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	172/778 - (22%)
Similarity:	298/778 - (38%)	Gaps:	214/778 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLSL-VAWLIFSLAWRTTPTACRQTNAPQSVQEM-LAEQLQSYMDTKARPCENFYQYACGNWQ 63
            :|.::| :.|:|.:..:||  ...:.||...:.|.: :|.:|.|.:|.:..||||||:|:|
Worm   207 LLSIALFLVWVITTDGFRT--IGAKSTNVCNTRQCIDIAFRLSSCIDDEIEPCENFYRYSC---- 265

  Fly    64 IQQQEQHSLRDRDWTRDRQ-RYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQ- 126
               |..||     .|.|:| .:..|        |.|.|:.|...||       |.|.||.:|.:
Worm   266 ---QRYHS-----QTADKQMSFLSQ--------LKDESLRRMHSLL-------SSEEDSRLLPKS 307

  Fly   127 ---MRLYYRSCKRL------KPYNLKKYLQLLP-----------PSNSTQWPSVGRGWRPER--- 168
               .|..|.:|...      .|.:|..:::..|           .::|..|         ||
Worm   308 ARLSRSLYSACMNAVLRSSNAPTDLLTFIRNFPCGPLLRDCQNFHADSYSW---------ERHAG 363

  Fly   169 -FDWITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSIYVNKPSRQETQPMGEGAMIEL------- 225
             .||..  ||..|     ::...:|.|:  |.....:.:..|.......:.|..:|:|
Worm   364 MLDWYA--GRYNL-----IVYDRDVHPQ--DRSKIILQIKPPDLTPIVGLIERDLIDLARPSPTE 419

  Fly   226 ---LLDIGQTKRTANALAR------------QVDDFERKLHRL-----QELEDDEGPREMQLGYL 270
               ||.:...:...:|.||            |:|:..|.:..|     |..........|.:|.:
Worm   420 FEPLLQLSLRQNLLSAFARDSLLRDPRDVQSQLDEVARLMVDLYISARQSASLTPNTTYMTIGEM 484

  Fly   271 DSYLPQLRWLSFMRQVRIDSELD--LRST----LIIENIPYLRALSDLMESESPDTVCSYIMLKW 329
            ...||||    ::|:. :|::|.  .|.|    |.|::..|...|||:|...|...|.:|::...
Worm   485 FQALPQL----YLREF-LDAQLSNTYRWTETDMLSIQDYDYFARLSDIMAQTSRQAVANYLLTVT 544

  Fly   330 LAFLKQ--QGPAD-ISRGECVAALRRAMPLASSWLVGQQ-FSDPESESY----VSSLFQRLKVRF 386
            :..|||  ..|.| ....|||..:       ||:.:|:: :.|..|::.    :....|.||:.|
Worm   545 VWNLKQYSYSPRDQYGWRECVDQI-------SSFEIGRKMYVDKASQTIDLPKIQEFLQNLKIDF 602

  Fly   387 GQILAENRMRLSPPLVHILQQKLRAVRLQMGF---FQTEEI--EDVEQYHVRIDLSGHSFYGNQL 446
               |:.:|   |.||.::  ..:..:...:||   .|.||:  :.|.|    :.|:...::.:.:
Worm   603 ---LSVHR---STPLQYL--SNINRLGFYVGFPRRLQNEELIWKPVSQ----VSLNETDYFDSMI 655

  Fly   447 VLLRQRV-EANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLPIW 510
                 || :|..|.....:..:.::..:.      ::..|:.:.||......:::|...::.||
Worm   656 -----RVGKAERDYTMSQIGTYLDNDDTT------TFPISDPTMLYNSNVGAIVIPLAFIEPPI- 708

  Fly   511 HRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQG------LQCLQ 569
                          ::...|:    .|.|: |.::|  :..::.|  |:.|.||      |:||.
Worm   709 --------------YLPGDEV----PMYGI-YSSLG--ITTLQMI--SKVFWQGLDKTSQLECLD 750

  Fly   570 QQM-------ATGSKWIDEKLADFVALRLAYETFF-----GVRDKREPRDPLLPQF----SQRQL 618
            ...       ...|..|:.:|...:.|..|:::..     ...|.....:..||.|    |.|.|
Worm   751 NVFRGFLDANRQRSPNIEPELLATIELADAFKSALYSYAKWQNDHHIHHEKTLPAFDSTDSMRSL 815

  Fly   619 FFITFAQFFCGRTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRC 681
             .:||:..||.... ..|.|..||.:...|:..|:         ||..|.|:..:::...:.|
Worm   816 -MLTFSTMFCSGEG-SEPGSDYEAMINTVAENSRM---------FSIHFNCNNSSRLYNRRTC 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	161/735 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	159/729 (22%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:387391	123/570 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010