DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-17

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	817	Identity:	158/817 - (19%)
Similarity:	286/817 - (35%)	Gaps:	243/817 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQR 83
            |.|...:.||.|...:..|:.:.:.:|    ||::||.|||||:. |....::.|.::..
Worm   859 TSTNVDKMNAYQMAVDYYAKSVNTAID----PCDDFYSYACGNFN-QSVSFYTARAQNLV----- 913

  Fly    84 YQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQL 148
            |..|.|...|.                   :::..|..::.::.:| |.:|           |..
Worm   914 YMAQKLEDPTY-------------------QTTINSSPALKKEKQL-YNAC-----------LTA 947

  Fly   149 LPPSNSTQWPSVGRGWRPERFDWITT-------------------------LGRLRLHGLNGVLL 188
            ...|.|.....:.:.:...:.|.:.|                         ||.|........|:
Worm   948 TASSQSEDQILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKLPSAKQIGDALGYLSFEQGIDTLI 1012

  Fly   189 REEVLPRW-DDSRNYSIYVNKP----SRQETQP----MGEGAMIELLLDI--------------G 230
            ...|...| |:|:.|.:::::.    |:...||    :.:...:::.||:              |
Worm  1013 SPLVDTYWIDNSKGYQMFIDQNTAYLSKTYYQPAAWKIEKPKYLKMALDVVTRYAREQNITLPAG 1077

  Fly   231 QTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGY-------LDSYLPQLRWLSFMR---- 284
            .:...:|.|     |:|:.: .::...||...|:.|..:       |.:....:.|::::.
Worm  1078 ASDLLSNVL-----DYEQNI-AVKYSTDDNTRRQFQRSWNLTKTSDLVTKYNFMDWMTYLSHAPN 1136

  Fly   285 --QVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWL------------AF--- 332
              :.:|.......|.:.::.:.:..|  |.:: :||:.:.:.:.::.|            ||
Worm  1137 AVKAKITDANYQVSVMEVDRLTHFSA--DYLQ-QSPELLVNLLFVRLLLGNAQYIPSYASAFRGM 1198

  Fly   333 -------------------------LKQQGPADISRGECVAALRRAMPLASSWLVGQQFSD---P 369
                                     |:..|||      |.:.....|..|:    |:.|.|   |
Worm  1199 TDESIFLGLSRRKTIPNHIPPPNFDLEANGPA------CASVANNLMQFAN----GRVFVDYMYP 1253

  Fly   370 ESESY-------------VSSLFQRLKVRFGQILAENRMRLSPPLVHILQ-----QKLRAVRLQM 416
            .::..             |.|.||.:..:...:..:.:.:.....|.|.|     ..::...|..
Worm  1254 TAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNIAFPDWIKNDTLLG 1318

  Fly   417 GFFQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSES 481
            .::.|..|.|.:.::   |:.......|..|...|...|..|.     |:|....|:     ..:
Worm  1319 NYYSTLVIADSDNFY---DIYDKLIKFNIFVQYNQLNAAQTDR-----TDFLGQPGT-----VNA 1370

  Fly   482 WEASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMG 546
            |        |....|.:..|.|:|..|.::.|......:..||.|..|||.||||..|:.:...|
Worm  1371 W--------YQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHELTHGFDDQGVQWGPTG 1427

  Fly   547 NIMGPVEEIGASRQFRQGLQCLQQQMA---------------TGSKWIDEKLADFVALRL---AY 593
            |:...::: .:...|:...||:..:.:               .|.:...|.:||...:..   ||
Worm  1428 NLARWMDD-NSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENIADNGGVHAAFNAY 1491

  Fly   594 ETFFGVRDKREPR--DPLLPQFSQRQLFFITFAQFFC--GRTP-------VLSPRSQSEAHLKHA 647
            :|...: |..:||  |.|..||:..||||::|||.:|  .||.       ::.|         |:
Worm  1492 KTHQSL-DGPDPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDP---------HS 1546

  Fly   648 ADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            ....||..|:.||..|...|.|...:|....|.|.:|
Worm  1547 PSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	151/792 (19%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	149/784 (19%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	151/794 (19%)
		M13	884..1581	CDD:189000	150/788 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020