Protein Alignment Nepl5 and nep-1

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 764
• Identity: 164/764 - (21%)
• Similarity: 296/764 - (38%)
• Gaps: 188/764 - (24%)

  Fly    30 QSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRD-----RDWTRDRQRYQGQML 89
            |....:|.:.|...:|    ||::|::|||..|    .:.|.:.|     ..:|..|::...:|
 Worm    70 QEASRLLQKSLNLSLD----PCDDFFEYACRAW----VDSHPIPDDLTSYSQFTATREKVLAEM- 125

  Fly    90 PTDTLGLIDHSVNRKLELLLRRRNESSFESDSSI-----LEQMRLYYRSCKRLKPYNLKKYLQLL 149
                         |||           :|.::||     :..::..|.:|...:.:|......||
 Worm   126 -------------RKL-----------YEDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARDLL 166

  Fly   150 PPSNS-TQWPSV-GRGWRPERFDWITTLGRLRLHGLNGVLLREEVLPRWD-----DSRN------ 201
            ....: ..||.| ...||...|| :|.|       |:..:...:|...:|     ||||
 Worm   167 EKIKTYGYWPMVHNEKWRESTFD-LTKL-------LSNTIQSRDVSVFFDFGPAEDSRNVSRRLL 223

  Fly   202 -----------------------------YSIYVNKPSRQETQPMG---EGAMIELLLD--IGQT 232
                                         |..|.....|..|:..|   ..:.||..:|  |...
 Worm   224 SFDQGSLGLGYSTRDYYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIAFE 288

  Fly   233 KRTANALARQVDDFE-RKLHRLQELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVR---IDSELD 293
            |..|..|..:.|... .||:.::..:|           |..|:..:.|........   :.|.|.
 Worm   289 KEWAQILVAEEDRRNYTKLYNVRRFDD-----------LKEYMSIIDWKKLTLSTTPFLVHSYLK 342

  Fly   294 LRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKW------------------LAF----LKQQ 336
            ...::||.::.||:.::.|:::..|..|.:||:|:|                  .||    .||:
 Worm   343 TNPSIIISDVEYLQKMNTLLQNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQR 407

  Fly   337 GPADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPL 401
            .|   ...:||::....:..||..:..:::.|..:::....:...|:..|..::..|....:...
 Worm   408 QP---RWKDCVSSAGGKLSYASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMHANDWMDAETK 469

  Fly   402 VHILQQKLRAVRLQMGF----FQTEEIEDVEQYHVRIDLSG---HSFYGNQLVLLRQRVEANHDL 459
            .:.|::..:.:: |:|:    ...|:::|..:     .|.|   .||  :|||  .:.::..::.
 Worm   470 KYALEKADQMLK-QIGYPDFILNDEKLDDWYK-----GLEGAPEDSF--SQLV--EKSIQWRNNF 524

  Fly   460 LYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMG 524
            .|..:....|    ...::|   .|:..:..|...||.:..|.|:||.|.:.........:..:|
 Worm   525 YYRRLLEPVN----RFEFIS---SAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIG 582

  Fly   525 FVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMA-----------TGSKW 578
            .|:.||:.||||..|..:|.:||:....:...:|: |.:..||:.:|.|           .|...
 Worm   583 AVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSK-FNERTQCIIEQYADVKLRGTDLRINGKLT 646

  Fly   579 IDEKLADFVALRLAYETFFGVRDKREPRDPLLPQF---SQRQLFFITFAQFFCG-RTPVLSPRSQ 639
            ..|.:||...::.|::.:....:|...::..||||   :..||||:.:||.:|| :||      :
 Worm   647 QGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTP------E 705

  Fly   640 SEAHL----KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            ::..|    .|:.:..||...|.|..||:..|.|...:.|..::||.:|
 Worm   706 TKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	158/742 (21%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	158/744 (21%)